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Product Details
PA5-87054
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein of human IL36A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2803807
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36alpha (IL-1F6), beta (IL-1F8), and gamma (IL-1F9). IL-36alpha is highly expressed in psoriatic plaques, as are IL-36beta and IL-36gamma, and is the only IL-1 family member found to be expressed by T cells, as well as monocytes and B cells. Primarily found in skin and lymphoid tissues, IL-36alpha is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36alpha signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36alpha also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FIL1 epsilon; Fil1epsilon; IL-1 epsilon; IL-1F6; IL-1F6 (FIL-1-epsilon); IL-1H1; interleukin 1; interleukin 1 family, member 6; interleukin 1 family, member 6 (epsilon); interleukin 1 family, member 9; interleukin 1, epsilon; Interleukin-1 epsilon; Interleukin-1 family member 6; Interleukin-1 homolog 1; Interleukin-36; Interleukin-36 alpha
Gene Aliases: FIL1; FIL1(EPSILON); FIL1E; IL-1F6; IL-1H1; IL1(EPSILON); IL1E; IL1F6; Il1f9; Il1h1; IL1RP2; IL36A
UniProt ID: (Human) Q9UHA7, (Mouse) Q9JLA2
Entrez Gene ID: (Human) 27179, (Mouse) 54448, (Rat) 296541
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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