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Product Details
PA5-96052
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 24-177 of human IL1RA (NP_7762141)
Conjugate
Form
Liquid
Concentration
1.23 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2807854
Product Specific Information
Positive Samples: 293T, HeLa, NIH/3T3, HL-60, BT-474, HT-29; Cellular Location: Cytoplasm
Immunogen sequence: ICRPSGRKSS KMQAFRIWDV NQKTFYLRNN QLVAGYLQGP NVNLEEKIDV VPIEPHALFL GIHGGKMCLS CVKSGDETRL QLEAVNITDL SENRKQDKRF AFIRSDSGPT TSFESAACPG WFLCTAMEAD QPVSLTNMPD EGVMVTKFYF QEDE
Target Information
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD121A; D2S1473; ICIL-1RA; IL 1 receptor antagonist; il-1 receptor; il-1r; IL-1RN; IL1 inhibitor; il1 receptor; IL1 receptor antagonist; IL1-RA; IL1R; IL1RN (IL1F3); interleukin-1 receptor; Interleukin-1 receptor antagonist protein; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); IRAP; MGC10430; P80; type II interleukin-1 receptor antagonist
Gene Aliases: DIRA; F630041P17Rik; ICIL-1RA; IL-1ra; IL-1ra3; IL-1RN; IL1F3; IL1RA; IL1RN; IRAP; MVCD4
UniProt ID: (Human) P18510, (Mouse) P25085, (Rat) P25086
Entrez Gene ID: (Human) 3557, (Mouse) 16181, (Rat) 60582
cytokine activity
interleukin-1, Type I receptor binding
interleukin-1, Type II receptor binding
interleukin-1 receptor antagonist activity
protein binding
interleukin-1 Type I receptor antagonist activity
interleukin-1 Type II receptor antagonist activity
interleukin-1 receptor binding
interleukin superfamily
lipid metabolic process
immune response
insulin secretion
negative regulation of heterotypic cell-cell adhesion
response to glucocorticoid
negative regulation of interleukin-1-mediated signaling pathway
fever generation
negative regulation of cytokine-mediated signaling pathway
acute-phase response
memory
negative regulation of glutamate secretion
cytokine-mediated signaling pathway
sensory perception of pain
negative regulation of cell migration
negative regulation of apoptotic process
positive regulation of JUN kinase activity
negative regulation of membrane potential
extracellular negative regulation of signal transduction
negative regulation of receptor activity
chronic inflammatory response to antigenic stimulus
female pregnancy
negative regulation of signal transduction
response to organonitrogen compound
response to organic cyclic compound
response to activity
carboxylic acid metabolic process
response to lipopolysaccharide
response to drug
response to starvation
response to interleukin-1
response to interleukin-4
cellular response to norepinephrine stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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