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Product Details
66319-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1D1C2
Immunogen
IL21R Fusion Protein Ag21295 (239-538 aa encoded by BC004348)
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LLLLLLVIV FIPAFWSLKT HPLWRLWKKI WAVPSPERFF MPLYKGCSGD FKKWVGAPFT GSSLELGPWS PEVPSTLEVY SCHPPRSPAK RLQLTELQEP AELVESDGVP KPSFWPTAQN SGGSAYSEER DRPYGLVSID TVTVLDAEGP CTWPCSCEDD GYPALDLDAG LEPSPGLEDP LLDAGTTVLS CGCVSAGSPG LGGPLGSLLD RLKPPLADGE DWAGGLPWGG RSPGGVSESE AGSPLAGLDM DTFDSGFVGS DCSSPVECDF TSPGDEGPPR SYLRQWVVIP PPLSSPGPQA S (239-538 aa encoded by BC004348)
Target Information
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD360; IL-21 receptor; Interleukin-21 receptor; MGC10967; Novel interleukin receptor
Gene Aliases: CD360; IL21R; NILR; UNQ3121/PRO10273
UniProt ID: (Human) Q9HBE5
Entrez Gene ID: (Human) 50615
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