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Product Details
H00058985-M03
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG3, kappa
Class
Monoclonal
Type
Antibody
Clone
6B5
Immunogen
IL22RA1 (AAH29273, 19 a.a. approximately 574 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: EDPSDLLQHV KFQSSNFENI LTWDSGPEGT PDTVYSIEYK TYGERDWVAK KGCQRITRKS CNLTVETGNL TELYYARVTA VSAGGRSATK MTDRFSSLQH TTLKPPDVTC ISKVRSIQMI VHPTPTPIRA GDGHRLTLED IFHDLFYHLE LQVNRTYQMH LGGKQREYEF FGLTPDTEFL GTIMICVPTW AKESAPYMCR VKTLPDRTWT YSFSGAFLFS MGFLVAVLCY LSYRYVTKPP APPNSLNVQR VLTFQPLRFI QEHVLIPVFD LSGPSSLAQP VQYSQIRVSG PREPAGAPQR HSLSEITYLG QPDISILQPS NVPPPQILSP LSYAPNAAPE VGPPSYAPQV TPEAQFPFYA PQAISKVQPS SYAPQATPDS WPPSYGVCME GSGKDSPTGT LSSPKHLRPK GQLQKEPPAG SCMLGGLSLQ EVTSLAMEES QEAKSLHQPL GICTDRTSDP NVLHSGEEGT PQYLKGQLPL LSSVQIEGHP MSLPLQPPSR PCSPSDQGPS PWGLLESLVC PKDEAKSPAP ETSDLEQPTE LDSLFRGLAL TVQWES
Target Information
A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CRF2-9; Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; il-22 receptor; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; ILN; Interleukin; interleukin 22 receptor, alpha 1; Interleukin-22 receptor subunit alpha-1; ZcytoR11
Gene Aliases: CRF2-9; IL22R; IL22R1; IL22RA1
UniProt ID: (Human) Q8N6P7
Entrez Gene ID: (Human) 58985
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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