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IL23R Antibody (PA5-79490) in WB
Western blot analysis of IL23 Receptor in, Lane 1: mouse brain tissue lysates, Lane 2: mouse liver tissue lysates, Lane 3: mouse kidney tissue lysates. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50 µg of sample under reducing conditions. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. The membrane was blocked with 5% Non-fat Milk/ TBS for 1. 5 hour at RT. The membrane w... View More
Product Details
PA5-79490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived mouse IL23 Receptor recombinant protein (Position: I25-D233).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2746606
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IBD17; IL 23R; IL-23 receptor; interleukin 23 receptor; interleukin 23 receptor-like; Interleukin-23 receptor
Gene Aliases: IL-23R; Il23r
UniProt ID: (Mouse) Q8K4B4
Entrez Gene ID: (Rat) 689932, (Mouse) 209590
positive regulation of defense response to virus by host
positive regulation of T-helper 1 type immune response
biological_process
response to lipopolysaccharide
negative regulation of interleukin-10 production
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
response to interferon-gamma
interleukin-23-mediated signaling pathway
immune system process
leukocyte mediated immunity
inflammatory response
JAK-STAT cascade
cytokine-mediated signaling pathway
innate immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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