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Invitrogen
IL24 Monoclonal Antibody (OTI4E1)
FIGURE: 1 / 5
IL24 Antibody (MA5-27141) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human pancreas tissue. To expose target proteins, heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min. Following antigen retrieval, tissues were probed with a IL24 monoclonal antibody (Product # MA5-27141) at a dilution of 1:150.
Product Details
MA5-27141
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4E1
Immunogen
Human recombinant protein fragment corresponding to amino acids 52-206 of IL24 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2723287
Target Information
Interleukin 24 (IL-24)/melanoma differentiation-associated gene-7 (mda-7) encodes a secreted protein that exhibits significant homology to the interleukin 10 (IL-10) family of cytokines. The human IL-24 is secreted by activated peripheral blood mononuclear cells and binds two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2 resulting in the activation of JAK/STAT signaling pathways. Mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: IL 24; IL-24; IL-4-induced secreted protein; Interleukin-24; MDA-7; melanocyte-associated Mda-7; Melanoma differentiation-associated gene 7 protein; suppression of tumorigenicity 16 (melanoma differentiation); Suppression of tumorigenicity 16 protein
Gene Aliases: C49A; FISP; IL10B; IL24; MDA7; MOB5; ST16
UniProt ID: (Human) Q13007
Entrez Gene ID: (Human) 11009
apoptotic process
inflammatory response
immune response
positive regulation of cell proliferation
negative regulation of cell proliferation
negative regulation of cell migration
serine phosphorylation of STAT3 protein
wound healing
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of JAK-STAT cascade
cellular response to lipopolysaccharide
cellular response to interleukin-4
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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