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Product Details
12655-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IL5RA Fusion Protein Ag3358 (50-335 aa encoded by BC027599)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: WKPNPDQEQ RNVNLEYQVK INAPKEDDYE TRITESKCVT ILHKGFSASV RTILQNDHSL LASSWASAEL HAPPGSPGTS IVNLTCTTNT TEDNYSRLRS YQVSLHCTWL VGTDAPEDTQ YFLYYRYGSW TEECQEYSKD TLGRNIACWF PRTFILSKGR DWLAVLVDGS SKHSAIRPFD QLFALHAIDQ INPPLNVTAE IEGTRLSIQW EKPVSAFPIH CFDYEVKIHN TRNGYLQIEK LMTNAFISII DDLSKYDVQV RAAVSSMCRE AGLWSEWSQP IYVGFSR (50-335 aa encoded by BC027599)
Target Information
Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cell replacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), which is composed of two chains: an alpha chain that binds IL-5 with low affinity and a beta chain that does not bind IL-5, but together with the IL-5 alpha chain, constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the alpha and beta chains is essential for signal transduction. Specifically, the membrane-proximal proline-rich sequence of the cytoplasmic domain of the IL-5R receptor alpha subunit, IL-5Ralpha, is critical for the IL-5 induced proliferative response, expression of nuclear proto-oncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD125; CD125 antigen; CDw125; IL-5 receptor alpha chain; IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA; interleukin 5 receptor type 3; interleukin 5 receptor, alpha; interleukin-5 receptor alpha chain; Interleukin-5 receptor subunit alpha
Gene Aliases: CD125; CDw125; HSIL5R3; IL5R; IL5RA
UniProt ID: (Human) Q14633, (Mouse) P21183
Entrez Gene ID: (Human) 3568, (Rat) 114103, (Mouse) 16192
MAPK cascade
inflammatory response to antigenic stimulus
signal transduction
cell proliferation
peptidyl-tyrosine phosphorylation
regulation of interleukin-5 production
interleukin-5-mediated signaling pathway
positive regulation of GTPase activity
cytokine-mediated signaling pathway
cellular response to organic substance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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