Proteintech

ISG20 Polyclonal Antibody

ISG20 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ISG20 Antibody (22097-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon tissue slide using 22097-1-AP ( ISG20 Antibody) at dilution of 1:50 (under 40x lens).

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Product Details

22097-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ISG20 Fusion Protein Ag17303 (1-150 aa encoded by BC007922)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAGSREVVA MDCEMVGLGP HRESGLARCS LVNVHGAVLY DKFIRPEGEI TDYRTRVSGV TPQHMVGATP FAVARLEILQ LLKGKLVVGH DLKHDFQALK EDMSGYTIYD TSTDRLLWRE AKLDHCRRVS LRVLSERLLH KSIQNSLLGH S (1-150 aa encoded by BC007922)

Target Information

Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Internal RNA 2'O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect.

Nucleic acids research

El Kazzi P,Rabah N,Chamontin C,Poulain L,Ferron F,Debart F,Canard B,Missé D,Coutard B,Nisole S,Decroly E

Tue Apr 11 00:00:00 EDT 2023

Proteomics Profiling Reveals Regulation of Immune Response to Salmonella enterica Serovar Typhimurium Infection in Mice.

Infection and immunity

Huang H,Even Z,Wang Z,Li L,Erickson A,Golovko M,Golovko S,Darland D,Mathur R,Wang X

Tue Jan 24 00:00:00 EST 2023

Integrated bioinformatics analysis and experimental validation reveal ISG20 as a novel prognostic indicator expressed on M2 macrophage in glioma.

BMC cancer

Peng Y,Liu H,Wu Q,Wang L,Yu Y,Yin F,Feng C,Ren X,Liu T,Chen L,Zhu H

Wed Jun 28 00:00:00 EDT 2023

Integrated bioinformatics analysis and experimental validation reveal ISG20 as a novel prognostic indicator expressed on M2 macrophage in glioma.

BMC cancer

Peng Y,Liu H,Wu Q,Wang L,Yu Y,Yin F,Feng C,Ren X,Liu T,Chen L,Zhu H

Wed Jun 28 00:00:00 EDT 2023

Characterization of the induction kinetics and antiviral functions of IRF1, ISG15 and ISG20 in cells infected with gammacoronavirus avian infectious bronchitis virus.

Virology

Liu SY,Huang M,Fung TS,Chen RA,Liu DX

Mon May 01 00:00:00 EDT 2023

RSAD2 Is an Effective Target for High-Yield Vaccine Production in MDCK Cells.

Viruses

Qiao Z,Liao Y,Pei M,Qiu Z,Liu Z,Jin D,Zhang J,Ma Z,Yang X

Mon Nov 21 00:00:00 EST 2022

Identification of key biomarkers and immune infiltration in renal interstitial fibrosis.

Annals of translational medicine

Hu Z,Liu Y,Zhu Y,Cui H,Pan J

Tue Feb 01 00:00:00 EST 2022

Identification and validation of a novel glycolysis-related gene signature for predicting the prognosis in ovarian cancer.

Cancer cell international

Yu J,Liu TT,Liang LL,Liu J,Cai HQ,Zeng J,Wang TT,Li J,Xiu L,Li N,Wu LY

Tue Jul 06 00:00:00 EDT 2021

Identification and validation of a novel glycolysis-related gene signature for predicting the prognosis in ovarian cancer.

Cancer cell international

Yu J,Liu TT,Liang LL,Liu J,Cai HQ,Zeng J,Wang TT,Li J,Xiu L,Li N,Wu LY

Tue Jul 06 00:00:00 EDT 2021

Placenta-derived interferon-stimulated gene 20 controls ZIKA virus infection.

EMBO reports

Ding J,Aldo P,Roberts CM,Stabach P,Liu H,You Y,Qiu X,Jeong J,Maxwell A,Lindenbach B,Braddock D,Liao A,Mor G

Tue Oct 05 00:00:00 EDT 2021

The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation.

PLoS pathogens

Wu N,Nguyen XN,Wang L,Appourchaux R,Zhang C,Panthu B,Gruffat H,Journo C,Alais S,Qin J,Zhang N,Tartour K,Catez F,Mahieux R,Ohlmann T,Liu M,Du B,Cimarelli A

Tue Oct 01 00:00:00 EDT 2019

Development and validation of an interferon signature predicting prognosis and treatment response for glioblastoma.

Oncoimmunology

Zhu C,Zou C,Guan G,Guo Q,Yan Z,Liu T,Shen S,Xu X,Chen C,Lin Z,Cheng W,Wu A

Wed Feb 03 00:00:00 EST 2021

Lnc-ISG20 Inhibits Influenza A Virus Replication by Enhancing ISG20 Expression.

Journal of virology

Chai W,Li J,Shangguan Q,Liu Q,Li X,Qi D,Tong X,Liu W,Ye X

Wed Aug 15 00:00:00 EDT 2018

Lnc-ISG20 Inhibits Influenza A Virus Replication by Enhancing ISG20 Expression.

Journal of virology

Chai W,Li J,Shangguan Q,Liu Q,Li X,Qi D,Tong X,Liu W,Ye X

Wed Aug 15 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: Estrogen-regulated transcript 45 protein; interferon stimulated exonuclease; interferon stimulated exonuclease 20; interferon stimulated exonuclease gene 20kDa; interferon stimulated gene 20kDa; Interferon-stimulated gene 20 kDa protein; interferon-stimulated protein; Promyelocytic leukemia nuclear body-associated protein ISG20; Protein DnaQL

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Gene Aliases: 1600023I01Rik; 2010107M23Rik; 20kDa; CD25; DnaQL; HEM45; ISG20

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UniProt ID: (Human) Q96AZ6, (Mouse) Q9JL16

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Entrez Gene ID: (Human) 3669, (Mouse) 57444, (Rat) 293052

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Function(s)

3'-5'-exoribonuclease activity exonuclease activity single-stranded DNA 3'-5' exodeoxyribonuclease activity exoribonuclease II activity U1 snRNA binding U2 snRNA binding U3 snoRNA binding metal ion binding nucleic acid binding RNA binding nuclease activity hydrolase activity exoribonuclease

Process(es)

DNA catabolic process, exonucleolytic rRNA processing RNA catabolic process cell proliferation response to virus negative regulation of viral genome replication defense response to virus type I interferon signaling pathway RNA phosphodiester bond hydrolysis, exonucleolytic immune system process innate immune response nucleic acid phosphodiester bond hydrolysis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ISG20 Polyclonal Antibody

ISG20 Antibody (22097-1-AP) in IHC (P)

Product Details

22097-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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