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Product Details
H00003670-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ISL1 (NP_002193, 1 a.a. approximately 346 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGDPPKKKRL ISLCVGCGNQ IHDQYILRVS PDLEWHAACL KCAECNQYLD ESCTCFVRDG KTYCKRDYIR LYGIKCAKCS IGFSKNDFVM RARSKVYHIE CFRCVACSRQ LIPGDEFALR EDGLFCRADH DVVERASLGA GDPLSPLHPA RPLQMAAEPI SARQPALRPH VHKQPEKTTR VRTVLNEKQL HTLRTCYAAN PRPDALMKEQ LVEMTGLSPR VIRVWFQNKR CKDKKRSIMM KQLQQQQPND KTNIQGMTGT PMVAASPERH DGGLQANPVE VQSYQPPWKV LSDFALQSDI DQPAFQQLVN FSEGGPGSNS TGSEVASMSS QLPDTPNSMV ASPIEA
Target Information
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Insulin gene enhancer protein ISL-1; ISL1 transcription factor, LIM/homeodomain; Islet-1
Gene Aliases: Isl-1; ISL1; ISLET1
UniProt ID: (Human) P61371
Entrez Gene ID: (Human) 3670
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription coactivator activity
enhancer sequence-specific DNA binding
chromatin binding
protein binding
zinc ion binding
ligand-dependent nuclear receptor binding
estrogen receptor binding
bHLH transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
secondary heart field specification
outflow tract septum morphogenesis
outflow tract morphogenesis
endocardial cushion morphogenesis
cardiac right ventricle morphogenesis
regulation of secondary heart field cardioblast proliferation
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of cell proliferation
positive regulation of vascular endothelial growth factor production
spinal cord motor neuron cell fate specification
spinal cord motor neuron differentiation
visceral motor neuron differentiation
trigeminal nerve development
pituitary gland development
pancreas development
axon regeneration
retinal ganglion cell axon guidance
positive regulation of insulin secretion
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
negative regulation of intracellular estrogen receptor signaling pathway
positive regulation of histone acetylation
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of DNA binding
negative regulation of neuron apoptotic process
negative regulation of neuron differentiation
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
neuron fate specification
mesenchymal cell differentiation
sensory system development
peripheral nervous system neuron axonogenesis
negative regulation of inflammatory response
ventricular cardiac muscle tissue morphogenesis
pharyngeal system development
cardiac muscle cell myoblast differentiation
innervation
atrial septum morphogenesis
cardiac cell fate determination
cellular response to glucocorticoid stimulus
positive regulation of granulocyte colony-stimulating factor production
negative regulation of protein homodimerization activity
negative regulation of canonical Wnt signaling pathway
positive regulation of macrophage colony-stimulating factor production
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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