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Influenza A (H1N1) virus is a subtype of influenza virus A and is the most common cause of influenza (flu) in humans. A strain of swine-origin H1N1 was responsible for the 2009 flu pandemic. H1N1PB2 protein is a well-documented component of the viral polymerase complex required for virus replication. The PB2 protein is involved in host range restriction and pathogenicity.
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