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Product Details
MA1-10515
Product Specifications
Species Reactivity
Bovine,
Human,
Pig
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
C7C9
Immunogen
Purified human Insulin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1076191
Product Specific Information
MA1-10515 detects Insulin from human, bovine, and porcine samples. Antibody will cross react with human proinsulin.
MA1-10515 has been successfully used in ELISA applications.
The MA1-10515 immunogen is purified human Insulin.
Target Information
Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ins; Insulin; preproinsulin; proinsulin
Gene Aliases: IDDM; IDDM1; IDDM2; ILPR; INS; IRDN; MODY10
UniProt ID: (Pig) P01315, (Human) P01308
Entrez Gene ID: (Pig) 397415, (Bovine) 280829, (Human) 3630
negative regulation of acute inflammatory response
glucose metabolic process
regulation of cellular amino acid metabolic process
acute-phase response
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
insulin receptor signaling pathway
lipid biosynthetic process
glycoprotein biosynthetic process
positive regulation of nitric oxide mediated signal transduction
positive regulation of glucose metabolic process
positive regulation of phosphatidylinositol 3-kinase signaling
lactate biosynthetic process
regulation of transmembrane transporter activity
positive regulation of cell migration
positive regulation of protein autophosphorylation
activation of protein kinase B activity
negative regulation of NAD(P)H oxidase activity
wound healing
lipoprotein biosynthetic process
negative regulation of protein catabolic process
glucose homeostasis
positive regulation of MAPK cascade
negative regulation of gluconeogenesis
positive regulation of fatty acid biosynthetic process
positive regulation of glycogen biosynthetic process
positive regulation of DNA replication
negative regulation of glycogen catabolic process
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
negative regulation of proteolysis
negative regulation of fatty acid metabolic process
positive regulation of glucose import
positive regulation of insulin receptor signaling pathway
alpha-beta T cell activation
negative regulation of protein secretion
positive regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of lipid catabolic process
positive regulation of lipoprotein lipase activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of protein kinase B signaling
fatty acid homeostasis
negative regulation of respiratory burst involved in inflammatory response
positive regulation of respiratory burst
positive regulation of protein localization to nucleus
positive regulation of dendritic spine maintenance
regulation of protein localization to plasma membrane
negative regulation of reactive oxygen species biosynthetic process
response to L-arginine
neuron projection maintenance
negative regulation of feeding behavior
signal transduction
feeding behavior
protein secretion
response to heat
response to glucose
positive regulation of gene expression
response to nutrient levels
positive regulation of insulin secretion
response to food
negative regulation of appetite
positive regulation of mammary gland epithelial cell proliferation
positive regulation of Rho protein signal transduction
estradiol secretion
negative regulation of apoptotic process
glucose import in response to insulin stimulus
positive regulation of protein secretion
response to growth hormone
positive regulation of peptide hormone secretion
positive regulation of cell maturation
negative regulation of lactation
positive regulation of lactation
positive regulation of blood circulation
response to butyrate
MAPK cascade
regulation of transcription, DNA-templated
ER to Golgi vesicle-mediated transport
cell-cell signaling
glucose transport
positive regulation of cell growth
positive regulation of cellular protein metabolic process
negative regulation of protein oligomerization
regulation of protein localization
cellular protein metabolic process
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
negative regulation of vasodilation
positive regulation of vasodilation
positive regulation of lipid biosynthetic process
regulation of protein secretion
positive regulation of nitric-oxide synthase activity
positive regulation of brown fat cell differentiation
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
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