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Product Details
INSR1-112AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 950-1000 on human Insulin receptor, transcript variant 2 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD 220; CD220; CD220 antigen; CD220 beta; HHF 5; Insulin receptor; insulin receptor preproprotein; IR; IR 1; IR beta; IR-1; IR1
Gene Aliases: 4932439J01Rik; CD220; D630014A15Rik; HHF5; INSR; IR; IR-A; IR-B
UniProt ID: (Human) P06213, (Mouse) P15208
Entrez Gene ID: (Human) 3643, (Rat) 24954, (Mouse) 16337
protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
insulin-activated receptor activity
insulin-like growth factor receptor binding
protein binding
ATP binding
GTP binding
protein phosphatase binding
lipoic acid binding
insulin-like growth factor I binding
insulin-like growth factor II binding
protein complex binding
3-phosphoinositide-dependent protein kinase binding
phosphatidylinositol 3-kinase binding
insulin binding
insulin receptor substrate binding
PTB domain binding
protein kinase activity
transmembrane receptor protein tyrosine kinase activity
protein kinase binding
protein domain specific binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
activation of MAPK activity
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
heart morphogenesis
carbohydrate metabolic process
regulation of transcription, DNA-templated
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
insulin receptor signaling pathway
epidermis development
male gonad development
response to manganese ion
regulation of hydrogen peroxide metabolic process
positive regulation of glycoprotein biosynthetic process
negative regulation of gene expression
response to activity
peptidyl-tyrosine phosphorylation
transformation of host cell by virus
signal transduction by protein phosphorylation
male sex determination
adrenal gland development
positive regulation of cell migration
exocrine pancreas development
activation of protein kinase activity
activation of protein kinase B activity
response to estradiol
negative regulation of transporter activity
cellular response to insulin stimulus
response to vitamin D
response to testosterone
response to tumor necrosis factor
peptidyl-tyrosine autophosphorylation
glucose homeostasis
positive regulation of MAPK cascade
positive regulation of nitric oxide biosynthetic process
fat cell differentiation
response to ethanol
positive regulation of glycogen biosynthetic process
positive regulation of DNA replication
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
regulation of embryonic development
positive regulation of glucose import
protein autophosphorylation
positive regulation of developmental growth
protein heterotetramerization
response to glucocorticoid
positive regulation of meiotic cell cycle
positive regulation of protein kinase B signaling
positive regulation of respiratory burst
cellular response to growth factor stimulus
regulation of female gonad development
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
response to hormone
response to glucose
organ morphogenesis
response to nutrient levels
response to insulin
positive regulation of phosphorylation
phosphorylation
intracellular signal transduction
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