Proteintech

Integrin alpha-6 Polyclonal Antibody

Integrin alpha-6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Integrin alpha-6 Antibody (27189-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney tissue slide using 27189-1-AP ( Integrin alpha-6 Antibody) at dilution of 1:200 (under 40x lens).

Integrin alpha-6 Antibody in Western Blot (WB)

Integrin alpha-6 Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

27189-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Flow Cytometry (Flow)

Assay-dependent

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Hamster

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Integrin alpha-6 Fusion Protein Ag25835 (477-690 aa encoded by BC136456)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TPNRIDLRQ KTACGAPSGI CLQVKSCFEY TANPAGYNPS ISIVGTLEAE KERRKSGLSS RVQFRNQGSE PKYTQELTLK RQKQKVCMEE TLWLQDNIRD KLRPIPITAS VEIQEPSSRR RVNSLPEVLP ILNSDEPKTA HIDVHFLKEG CGDDNVCNSN LKLEYKFCTR EGNQDKFSYL PIQKGVPELV LKDQKDIALE ITVTNSPSNP RNPTK (477-690 aa encoded by BC136456)

Target Information

CDf (Integrin alpha-6, ITGA6) is the integrin alpha chain alpha 6 protein. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signaling. Two transcript variants encoding different isoforms have been found for CDf. Functionally, integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals that affect cellular shape, mobility, and progression through the cell cycle in response to the extracellular matrix. Integrin receptors are composed of alpha and beta subunits, and form structural and functional linkages between the ECM (extra-cellular matrix) and intracellular cytoskeletal linker proteins. Signaling mediated by Intergrin/ECM interactions are also integrated with cellular responses to growth factor signaling to regulate cellular proliferation, cytoskeletal reorganization and other responses necessary for cellular survival. CDf is predominantly expressed by epithelia, and plays a critical structural role in the hemidesmosome. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A Novel Three-Dimensional Follicle Culture System Decreases Oxidative Stress and Promotes the Prolonged Culture of Human Granulosa Cells.

ACS applied materials & interfaces

Zhao X,Zhang S,Gao S,Chang HM,Leung PCK,Tan J

Wed Mar 29 00:00:00 EDT 2023

Expression of type VI collagen α3 chain in canine mammary carcinomas.

Research in veterinary science

Araki M,Noguchi S,Kubo Y,Yasuda A,Koh M,Otsuka H,Yokosuka M,Soeta S

Thu Jun 01 00:00:00 EDT 2023

Expression of type VI collagen α3 chain in canine mammary carcinomas.

Research in veterinary science

Araki M,Noguchi S,Kubo Y,Yasuda A,Koh M,Otsuka H,Yokosuka M,Soeta S

Thu Jun 01 00:00:00 EDT 2023

Expression of receptor-type tumour endothelial marker 8 in carcinoma cells showing luminal progenitor-like phenotypes in canine mammary gland carcinomas.

Journal of comparative pathology

Araki M,Noguchi S,Kubo Y,Yasuda A,Koh M,Otsuka H,Yokosuka M,Soeta S

Sun Jan 01 00:00:00 EST 2023

Midkine mediates dysfunction of liver sinusoidal endothelial cells through integrin α4 and α6.

Vascular pharmacology

Wu L,Chen H,Fu C,Xing M,Fang H,Yang F,Yang Q,Zhang Y,Li W,Chen Z

Thu Dec 01 00:00:00 EST 2022

EBV promotes vascular mimicry of dormant cancer cells by potentiating stemness and EMT.

Experimental cell research

Cheng T,Zhang S,Xia T,Zhang Y,Ji Y,Pan S,Xie H,Ren Q,You Y,You B

Thu Dec 15 00:00:00 EST 2022

Glycoengineering human neural stem cells (hNSCs) for adhesion improvement using a novel thiol-modified N-acetylmannosamine (ManNAc) analog.

Biomaterials advances

Du J,Liu X,Yarema KJ,Jia X

Tue Mar 01 00:00:00 EST 2022

Single-Cell RNA-Seq Reveals Heterogeneity of Cell Communications between Schwann Cells and Fibroblasts within Vestibular Schwannoma Microenvironment.

The American journal of pathology

Xu M,Wang S,Jiang Y,Wang J,Xiong Y,Dong W,Yao Q,Xing Y,Liu F,Chen Z,Yu D

Thu Sep 01 00:00:00 EDT 2022

Gelatin-grafted tubular asymmetric scaffolds promote ureteral regeneration via activation of the integrin/Erk signaling pathway.

Frontiers in bioengineering and biotechnology

Song B,Fang L,Mao X,Ye X,Yan Z,Ma Q,Shi Z,Hu Y,Zhu Y,Cheng Y

Wed Feb 01 00:00:00 EST 2023

TM4SF1 promotes esophageal squamous cell carcinoma metastasis by interacting with integrin α6.

Cell death & disease

Hou S,Hao X,Li J,Weng S,Wang J,Zhao T,Li W,Hu X,Deng B,Gu J,Hang Q

Thu Jul 14 00:00:00 EDT 2022

IQGAP3 in clear cell renal cell carcinoma contributes to drug resistance and genome stability.

PeerJ

Li W,Wang Z,Wang H,Zhang J,Wang X,Xing S,Chen S

Mon Jan 23 00:00:00 EST 2023

Comparative Analysis of mRNA and miRNA Expression between Dermal Papilla Cells and Hair Matrix Cells of Hair Follicles in Yak.

Cells

Zhang X,Bao P,Zheng Q,Chu M,Liang C,Guo X,Wu X,He M,Pei C,Yan P

Fri Dec 09 00:00:00 EST 2022

The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.

Journal of reproductive immunology

Wu S,Liu H,Zhou M,Shang Y,Luo L,Chen J,Yang J

Mon Aug 01 00:00:00 EDT 2022

The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.

Journal of reproductive immunology

Wu S,Liu H,Zhou M,Shang Y,Luo L,Chen J,Yang J

Mon Aug 01 00:00:00 EDT 2022

Interleukin-26-DNA complexes promote inflammation and dermal-epidermal separation in a modified human cryosection model of bullous pemphigoid.

Frontiers in immunology

Mizuno Y,Shibata S,Ito Y,Taira H,Sugimoto E,Awaji K,Sato S

Thu Nov 03 00:00:00 EDT 2022

Role of intestinal extracellular matrix-related signaling in porcine epidemic diarrhea virus infection.

Virulence

Li Y,Li J,Wang X,Wu Q,Yang Q

Wed Dec 01 00:00:00 EST 2021

Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth.

Stem cell research & therapy

Leng L,Ma J,Lv L,Wang W,Gao D,Zhu Y,Wu Z

Wed Sep 23 00:00:00 EDT 2020

MicroRNA-377-3p alleviates IL-1β-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6.

Biochemical and biophysical research communications

Tu Y,Ma T,Wen T,Yang T,Xue L,Cai M,Wang F,Guan M,Xue H

Wed Feb 26 00:00:00 EST 2020

NFAT1 Hypermethylation Promotes Epithelial-Mesenchymal Transition and Metastasis in Nasopharyngeal Carcinoma by Activating ITGA6 Transcription.

Neoplasia (New York, N.Y.)

Zhang J,Zheng ZQ,Yuan YW,Zhang PP,Li YQ,Wang YQ,Tang XR,Wen X,Hong XH,Lei Y,He QM,Yang XJ,Sun Y,Ma J,Liu N

Fri Mar 01 00:00:00 EST 2019

NFAT1 Hypermethylation Promotes Epithelial-Mesenchymal Transition and Metastasis in Nasopharyngeal Carcinoma by Activating ITGA6 Transcription.

Neoplasia (New York, N.Y.)

Zhang J,Zheng ZQ,Yuan YW,Zhang PP,Li YQ,Wang YQ,Tang XR,Wen X,Hong XH,Lei Y,He QM,Yang XJ,Sun Y,Ma J,Liu N

Fri Mar 01 00:00:00 EST 2019

MiR-302a-5p suppresses cell proliferation and invasion in non-small cell lung carcinoma by targeting ITGA6.

American journal of translational research

Chen W,Zhuang X,Qi R,Qiao T

Thu Oct 01 00:00:00 EDT 2020

MiR-302a-5p suppresses cell proliferation and invasion in non-small cell lung carcinoma by targeting ITGA6.

American journal of translational research

Chen W,Zhuang X,Qi R,Qiao T

Thu Oct 01 00:00:00 EDT 2020

Single-Cell Analysis of the Impact of Host Cell Heterogeneity on Infection with Foot-and-Mouth Disease Virus.

Journal of virology

Xin X,Wang H,Han L,Wang M,Fang H,Hao Y,Li J,Zhang H,Zheng C,Shen C

Tue May 01 00:00:00 EDT 2018

Single-Cell Analysis of the Impact of Host Cell Heterogeneity on Infection with Foot-and-Mouth Disease Virus.

Journal of virology

Xin X,Wang H,Han L,Wang M,Fang H,Hao Y,Li J,Zhang H,Zheng C,Shen C

Tue May 01 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: CD49 antigen-like family member F; CD49f; DKFZp686J01244; FLJ18737; integrin alpha 6; Integrin alpha-6; integrin alpha6B; integrin, alpha 6; VLA-6

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Gene Aliases: 5033401O05Rik; AI115430; CD49f; ITGA6; ITGA6B; VLA-6

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UniProt ID: (Human) P23229, (Mouse) Q61739

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Entrez Gene ID: (Human) 3655, (Rat) 114517, (Mouse) 16403

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Function(s)

integrin binding protein binding insulin-like growth factor I binding neuregulin binding metal ion binding cadherin binding involved in cell-cell adhesion protein complex binding laminin binding integrin

Process(es)

cell-substrate junction assembly cell-matrix adhesion integrin-mediated signaling pathway ectodermal cell differentiation positive regulation of cell-cell adhesion extracellular matrix organization hemidesmosome assembly cell-substrate adhesion cellular response to extracellular stimulus cell adhesion mediated by integrin nail development positive regulation of phosphorylation positive regulation of apoptotic process positive regulation of GTPase activity skin development positive regulation of transcription from RNA polymerase II promoter filopodium assembly digestive tract development brown fat cell differentiation leukocyte migration renal system development amelogenesis cell-cell adhesion negative regulation of extrinsic apoptotic signaling pathway positive regulation of cell-substrate adhesion single organismal cell-cell adhesion odontogenesis of dentin-containing tooth cellular response to organic cyclic compound cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Integrin alpha-6 Polyclonal Antibody

Integrin alpha-6 Antibody (27189-1-AP) in IHC (P)

Product Details

27189-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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