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Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene. This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants.
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Protein Aliases: Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2; PeP; Peroxisomal protein
Gene Aliases: 1500001L03Rik; AI836596; C87088; FNDC5; FRCP2; irisin; PeP; Pxp
UniProt ID: (Human) Q8NAU1, (Mouse) Q8K4Z2
Entrez Gene ID: (Human) 252995, (Mouse) 384061
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