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JAB1 Antibody (PA5-29872) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of JAB1 was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: JAB1 Polyclonal Antibody (Product # PA5-29872) diluted at 1:200. Red: FIS1, a mitochondria marker. Blue: Hoechst 33342 staining.
Product Details
PA5-29872
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 198 of Human JAB1
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2547346
Product Specific Information
Recommended positive controls: HeLa, mouse brain.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (99%), Xenopus laevis (99%), Pig (100%), Chicken (99%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the "Signalosome", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 38 kDa Mov34 homolog; COP9 complex S5; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; Jun activation domain-binding protein 1; Jun coactivator; Kip1 C-terminus-interacting protein 2; MGC3149; SGN5; signalosome subunit 5; testis secretory sperm-binding protein Li 231m
Gene Aliases: AI303502; COPS5; CSN5; JAB1; Kic2; MOV-34; Mov34; SGN5
UniProt ID: (Human) Q92905, (Mouse) O35864
Entrez Gene ID: (Human) 10987, (Mouse) 26754
protein deneddylation
nucleotide-excision repair, DNA damage recognition
transcription-coupled nucleotide-excision repair
transcription from RNA polymerase II promoter
translation
translational initiation
cullin deneddylation
protein deubiquitination
positive regulation of transcription from RNA polymerase II promoter
regulation of JNK cascade
regulation of cell cycle
regulation of IRE1-mediated unfolded protein response
exosomal secretion
regulation of transcription, DNA-templated
proteolysis
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