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JAM-C Antibody (A303-761A) in IHC
Detection of human JAM-C by immunohistochemistry. Sample: FFPE section of human blood vessel. Antibody: Affinity purified rabbit anti- JAM-C (Cat. No. A303-761A Lot1) used at a dilution of 1:1,000 (1µg/ml). Detection: DAB. Counterstain: Hematoxylin (blue).
Product Details
A303-761A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 260 and 310 of human Junctional Adhesion Molecule C.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
JAM3 is involved in tight junctions and represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: JAM-2; JAM-3; JAM-C; Junctional adhesion molecule 3; Junctional adhesion molecule C
Gene Aliases: JAM-2; JAM-3; JAM-C; JAM3; JAMC; UNQ859/PRO1868
UniProt ID: (Human) Q9BX67
Entrez Gene ID: (Human) 83700
angiogenesis
neutrophil homeostasis
adaptive immune response
myeloid progenitor cell differentiation
leukocyte migration involved in inflammatory response
cell-matrix adhesion
spermatid development
transmission of nerve impulse
establishment of cell polarity
extracellular matrix organization
axon regeneration
myelination
leukocyte migration
regulation of neutrophil chemotaxis
regulation of actin cytoskeleton organization by cell-cell adhesion
Performance Guarantee
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