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Product Details
21302-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
JAML Fusion Protein Ag15900 (40-275 aa encoded by BC100797)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VPIGRFQNR VHLMGDILCN DGSLLLQDVQ EADQGTYICE IRLKGESQVF KKAVVLHVLP EEPKELMVHV GGLIQMGCVF QSTEVKHVTK VEWIFSGRRA KEEIVFRYYH KLRMSVEYSQ SWGHFQNRVN LVGDIFRNDG SIMLQGVRES DGGNYTCSIH LGNLVFKKTI VLHVSPEEPR TLVTPAALRP LVLGGNQLVI IVGIVCATIL LLPVLILIVK KTCGNKSSVN STVLVKN (40-275 aa encoded by BC100797)
Target Information
AMICA transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adhesion molecule AMICA; Adhesion molecule interacting with CXADR antigen 1; adhesion molecule, interacts with CXADR antigen 1; Dendritic cell-specific protein CREA7-1; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; Junctional adhesion molecule-like
Gene Aliases: AMICA; AMICA1; CREA7-1; CREA7-4; Gm638; JAML; UNQ722/PRO1387
UniProt ID: (Human) Q86YT9
Entrez Gene ID: (Human) 120425
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
neutrophil chemotaxis
monocyte extravasation
gamma-delta T cell activation
regulation of immune response
leukocyte migration
positive regulation of epithelial cell proliferation involved in wound healing
neutrophil extravasation
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