Proteintech

JNK Monoclonal Antibody (1A12E1)

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Antibody Testing Data (12)

JNK Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 12

JNK Antibody (66210-1-IG) in ICC/IF

Immunofluorescent analysis of HeLa cells using 66210-1-IG (JNK antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IGG (H+L).

JNK Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

66210-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 83 publications 83 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1A12E1

Immunogen

JNK Fusion Protein Ag21426 (1-427 aa encoded by BC130572)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.8 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This protein can be phosphorylated and this antibody recognizes the 46 kDa and 55 kDa bands in western blot.

Immunogen sequence: MSRSKRDNN FYSVEIGDST FTVLKRYQNL KPIGSGAQGI VCAAYDAILE RNVAIKKLSR PFQNQTHAKR AYRELVLMKC VNHKNIIGLL NVFTPQKSLE EFQDVYIVME LMDANLCQVI QMELDHERMS YLLYQMLCGI KHLHSAGIIH RDLKPSNIVV KSDCTLKILD FGLARTAGTS FMMTPYVVTR YYRAPEVILG MGYKENVDIW SVGCIMGEMI KGGVLFPGTD HIDQWNKVIE QLGTPCPEFM KKLQPTVRTY VENRPKYAGY SFEKLFPDVL FPADSEHNKL KASQARDLLS KMLVIDASKR ISVDEALQHP YINVWYDPSE AEAPPPKIPD KQLDEREHTI EEWKELIYKE VMDLEERTKN GVIRGQPSPL AQVQQ (1-427 aa encoded by BC130572)

Target Information

C-Jun N-terminal Kinase (JNK) is also known as Mitogen-activated protein kinase (MAPK8). It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation.

Medical oncology (Northwood, London, England)

Liu K,Lu R,Zhao Q,Du J,Li Y,Zheng M,Zhang S

Sat Nov 16 00:00:00 EST 2019

Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling.

Free radical biology & medicine

Wu W,Wang S,Liu Q,Wang X,Shan T,Wang Y

Sat Dec 01 00:00:00 EST 2018

Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling.

Free radical biology & medicine

Wu W,Wang S,Liu Q,Wang X,Shan T,Wang Y

Sat Dec 01 00:00:00 EST 2018

Metformin Protects against LPS-Induced Intestinal Barrier Dysfunction by Activating AMPK Pathway.

Molecular pharmaceutics

Wu W,Wang S,Liu Q,Shan T,Wang Y

Mon Aug 06 00:00:00 EDT 2018

Involvement of JNK signaling in IL4-induced M2 macrophage polarization.

Experimental cell research

Hao J,Hu Y,Li Y,Zhou Q,Lv X

Tue Aug 15 00:00:00 EDT 2017

Involvement of JNK signaling in IL4-induced M2 macrophage polarization.

Experimental cell research

Hao J,Hu Y,Li Y,Zhou Q,Lv X

Tue Aug 15 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: c-Jun kinase 2; c-Jun N-terminal kinase 1; c-Jun N-terminal kinase 2; c-Jun N-terminal kinase 3; FLJ12099; FLJ33785; JNK 46; JNK 55; JNK-46; JNK-55; JNK/SAPK alpha; JNK1 beta1 protein kinase; JNK3 alpha protein kinase; JNK3 beta1 protein kinase; JNK3 beta2 protein kinase; Jun kinase; JUN N-terminal kinase; MAP kinase 10; MAP kinase 8; MAP kinase 9; MAP kinase p49 3F12; MAPK 10; MAPK 8; MAPK 9; MGC50974; Mi; mitogen activated protein kinase 10; mitogen activated protein kinase 8; mitogen activated protein kinase 9; Mitogen-activated protein kinase 10; Mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; Mitogen-activated protein kinase 9; MK10; p54 gamma; p54-alpha; p54-beta; Phospho-JNK; protein kinase mitogen-activated 8; protein kinase, mitogen-activated 9; SAPK gamma; SAPK-alpha; SAPK-beta; SAPK/Erk/kinase 2; SAPK1a; SAPK1b; SAPK1c; stress activated protein kinase alpha II; Stress activated protein kinase beta; stress-activated protein kinase 1; Stress-activated protein kinase 1a; Stress-activated protein kinase 1b; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1; Stress-activated protein kinase JNK2; Stress-activated protein kinase JNK3

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Gene Aliases: AI849689; AI851083; C230008H04Rik; JNK; JNK-46; JNK-55; JNK1; JNK1A2; JNK2; JNK21B1/2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; JNK3; JNK3A; JNK3B1; JNK3B2; MAPK10; MAPK8; MAPK9; p493F12; p54a; p54aSAPK; p54bSAPK; PRKM10; PRKM8; PRKM9; SAPb; SAPK; SAPK(beta); SAPK1; SAPK1A; SAPK1B; SAPK1C; SAPKC; Serk2

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UniProt ID: (Human) P53779, (Human) P45983, (Human) P45984, (Mouse) Q61831, (Rat) P49187, (Rat) P49185, (Mouse) Q91Y86, (Rat) P49186, (Mouse) Q9WTU6

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Entrez Gene ID: (Human) 5602, (Human) 5599, (Human) 5601, (Mouse) 26414, (Rat) 25272, (Rat) 116554, (Mouse) 26419, (Rat) 50658, (Mouse) 26420

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Function(s)

JUN kinase activity MAP kinase kinase activity protein binding ATP binding protein serine/threonine kinase activity kinase activity enzyme binding histone deacetylase regulator activity histone deacetylase binding transcription factor binding cysteine-type endopeptidase activator activity involved in apoptotic process mitogen-activated protein kinase kinase kinase binding nucleotide binding protein kinase activity MAP kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase

Process(es)

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JNK Monoclonal Antibody (1A12E1)

JNK Antibody (66210-1-IG) in ICC/IF

Product Details

66210-1-IG

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Immunocytochemistry (ICC/IF)

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