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Product Details
10854-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
JP45/JSRP1 Fusion Protein Ag1300 (1-331 aa encoded by BC021201)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSMTTRAWE ELDGGLGSCQ ALEDHSALAE TQEDRASATP RLADSGSVPH DSQVAEGPSV DTRPKKMEKE PAARGTPGTG KERLKAGASP RSVPARKKAQ TAPPLQPPPP PPALSEELPW GDLSLNKCLV LASLVALLGS AFQLCRDAVP GEAALQARVP EPWVPPSSAP REPSSPLPKF EAQAPPSAPP APRAEAEVRP KIPGSREAAE NDEEEPGEAT GEAVREDRVT LADRGPKERP RREGKPRKEK PRKEERPKKE RPRKEERPRA AREPREALPQ RWESREGGHR PWARDSRDAE PRKKQAWVSP RRPDEEQRPG SRQKLRAGKG RD (1-331 aa encoded by BC021201)
Target Information
The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPR and RyR. Another skeletal muscle specific 90 kDa protein has also been localized to the this junction. This protein is phosphorylated by an intrinsic protein kinase in triads suggesting that it may play an important regulatory or structural role in the skeletal muscle triad junction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2310032K21Rik; homolog of mouse skeletal muscle sarcoplasmic reticulum protein JP-45; JP-45; Junctional sarcoplasmic reticulum protein 1; Junctional SR; Junctional-face membrane protein of 45 kDa homolog; skeletal muscle sarcoplasmic reticulum protein JP-45
Gene Aliases: JP-45; JP45; JSRP1
UniProt ID: (Human) Q96MG2
Entrez Gene ID: (Human) 126306
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