Invitrogen

Jagged1 Polyclonal Antibody

Jagged1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Jagged1 Antibody (PA5-72843) in IHC (P)

Immunohistochemistry of JAG1 in human spleen tissue with Jagged1 Polyclonal Antibody (Product # PA5-72843) at 5 µg/mL.

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Product Details

PA5-72843

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL

View 1 publication 1 publication

ELISA (ELISA)

Assay-Dependent

ChIP assay (ChIP)

- -

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

JAG1 antibody for a 19 amino acid peptide near the carboxy terminus of human JAG1. The immunogen is within the last 50 amino acids of JAG1.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2718697

Target Information

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Jagged 1 Regulates The Proliferation and Metastasis of Human MDA-T68 Thyroid Cancer Cells.

Cell journal

Chen J,Wang X,Zhang X,Yin J,Zheng Y

Published figure using Jagged1 polyclonal antibody (Product # PA5-72843) in Immunohistochemistry (Paraffin)

Wed Jun 28 00:00:00 EDT 2023

C/D box snoRNA SNORD113-6/AF357425 plays a dual role in integrin signalling and arterial fibroblast function via pre-mRNA processing and 2'O-ribose methylation.

Human molecular genetics

van Ingen E,van den Homberg DAL,van der Bent ML,Mei H,Papac-Milicevic N,Kremer V,Boon RA,Quax PHA,Wojta J,Nossent AY

Published figure using Jagged1 polyclonal antibody (Product # PA5-72843) in Western Blot

Thu Mar 31 00:00:00 EDT 2022

Nuclear and Membrane Receptors for Sex Steroids Are Involved in the Regulation of Delta/Serrate/LAG-2 Proteins in Rodent Sertoli Cells.

International journal of molecular sciences

Lustofin S,Kamińska A,Brzoskwinia M,Cyran J,Kotula-Balak M,Bilińska B,Hejmej A

Published figure using Jagged1 polyclonal antibody (Product # PA5-72843) in Western Blot

Fri Feb 18 00:00:00 EST 2022

A dopamine-methacrylated hyaluronic acid hydrogel as an effective carrier for stem cells in skin regeneration therapy.

Cell death & disease

Gong M,Yan F,Yu L,Li F

PA5-72843 was used in Western Blotting to study a dopamine-methacrylated hyaluronic acid hydrogel as an effective carrier for stem cells in skin regeneration therapy.

Sat Aug 27 00:00:00 EDT 2022

Propofol alleviates neuropathic pain in chronic constriction injury rat models via the microRNA-140-3p/Jagged-1 peptide/Notch signaling pathway.

Synapse (New York, N.Y.)

Cheng F,Qin W,Yang AX,Yan FF,Chen Y,Ma JX

PA5-72843 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to indicate that propofol inhibits inflammatory responses and the Notch signaling pathway via miR-140-3p/JAG1 to alleviate NP.

Fri Oct 01 00:00:00 EDT 2021

Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium.

Reproductive biology and endocrinology : RB&E

Kamińska A,Marek S,Pardyak L,Brzoskwinia M,Pawlicki P,Bilińska B,Hejmej A

PA5-72843 was used in Immunohistochemistry to examine whether activation of Notch receptors and expression of Notch ligands and effector genes in rat seminiferous epithelium are controlled by androgen signaling during puberty.

Thu Apr 16 00:00:00 EDT 2020

Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium.

Reproductive biology and endocrinology : RB&E

Kamińska A,Marek S,Pardyak L,Brzoskwinia M,Pawlicki P,Bilińska B,Hejmej A

Thu Apr 16 00:00:00 EDT 2020

Disruption of androgen signaling during puberty affects Notch pathway in rat seminiferous epithelium.

Reproductive biology and endocrinology : RB&E

Kamińska A,Marek S,Pardyak L,Brzoskwinia M,Pawlicki P,Bilińska B,Hejmej A

Thu Apr 16 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: CD339; jagged canonical Notch ligand 1; Jagged1; Protein jagged-1; Serrate-1

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Gene Aliases: ABE2; AGS; AHD; AWS; CD339; Gsfabe2; HJ1; Htu; JAG1; JAGL1; Ozz; Ser-1

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UniProt ID: (Human) P78504, (Mouse) Q9QXX0, (Rat) Q63722

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Entrez Gene ID: (Human) 182, (Mouse) 16449, (Rat) 29146

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Function(s)

Notch binding structural molecule activity calcium ion binding protein binding growth factor activity

Process(es)

angiogenesis cell fate determination blood vessel remodeling morphogenesis of an epithelial sheet T cell mediated immunity pulmonary valve morphogenesis cardiac right ventricle morphogenesis Notch signaling pathway Notch receptor processing nervous system development hemopoiesis keratinocyte differentiation regulation of cell migration response to muramyl dipeptide aorta morphogenesis regulation of cell proliferation auditory receptor cell differentiation myoblast differentiation endothelial cell differentiation negative regulation of fat cell differentiation positive regulation of myeloid cell differentiation negative regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter cardiac septum morphogenesis ciliary body morphogenesis pulmonary artery morphogenesis cardiac neural crest cell development involved in outflow tract morphogenesis Notch signaling involved in heart development endocardial cushion cell development nephron development glomerular visceral epithelial cell development distal tubule development loop of Henle development neuronal stem cell population maintenance negative regulation of stem cell differentiation cell communication multicellular organism development organ morphogenesis camera-type eye development negative regulation of cell differentiation inner ear development organ regeneration

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Jagged1 Polyclonal Antibody

Jagged1 Antibody (PA5-72843) in IHC (P)

Product Details

PA5-72843

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

ELISA (ELISA)

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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