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Product Details
JAMA-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Non-human primate,
Panda,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 250-299 on human Junctional Adhesion Molecule A protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. CD321 is a 32-41 kD glycoprotein, possessing two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail. The protein assembles at the membrane as a homodimer, and can associate laterally with other membrane proteins including integrins. CD321 is expressed on a variety of cell types, including leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and plays a role in mediating cell-cell contact. CD321 can be found in close proximity to several components of epithelial tight junctions, including ZO-1 and occludin. CD321 is involved in the maintenance of epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion, and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BV11 antigen; CD321; F11 R; F11 receptor/F11R; JAM-1; JAM-A; junction cell adhesion molecule A; junction cell adhesion molecule1; Junctional adhesion molecule 1; Junctional adhesion molecule A; PAM-1; Platelet adhesion molecule 1; Platelet F11 receptor
Gene Aliases: 9130004G24; AA638916; CD321; ESTM33; F11R; JAM; JAM-1; JAM-A; JAM1; JAMA; JCAM; Jcam1; KAT; Ly106; PAM-1; UNQ264/PRO301
UniProt ID: (Bovine) Q9XT56, (Human) Q9Y624, (Mouse) O88792, (Rat) Q9JHY1
Entrez Gene ID: (Bovine) 281258, (Human) 50848, (Mouse) 16456, (Rat) 116479
cell adhesion
viral process
epithelial cell differentiation
actomyosin structure organization
negative regulation of GTPase activity
positive regulation of GTPase activity
positive regulation of blood pressure
intestinal absorption
establishment of protein localization to plasma membrane
establishment of endothelial intestinal barrier
regulation of membrane permeability
regulation of actin cytoskeleton reorganization
response to radiation
cell differentiation
regulation of cytokine production
inflammatory response
transforming growth factor beta receptor signaling pathway
extracellular matrix organization
viral entry into host cell
leukocyte migration
bicellular tight junction assembly
cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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