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Product Details
17188-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KCNN3 Fusion Protein Ag10972 (550-736 aa encoded by BC042147)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KLELTKAEK HVHNFMMDTQ LTKRIKNAAA NVLRETWLIY KHTKLLKKID HAKVRKHQRK FLQAIHQLRS VKMEQRKLSD QANTLVDLSK MQNVMYDLIT ELNDRSEDLE KQIGSLESKL EHLTASFNSL PLLIADTLRQ QQQQLLSAII EARGVSVAVG TTHTPISDSP IGVSSTSFPT PYTSSSSC (550-736 aa encoded by BC042147)
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: KCa2.3; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; SK3; SKCa 3; SKCa3; small conductance calcium-activated potassium channel 3; Small conductance calcium-activated potassium channel protein 3; small-conductance Ca2+-activated K+ channel 3
Gene Aliases: hSK3; K3; KCa2.3; KCNN3; SK3; SKCA3
UniProt ID: (Human) Q9UGI6, (Mouse) P58391, (Rat) P70605
Entrez Gene ID: (Human) 3782, (Mouse) 140493, (Rat) 54263
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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