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FIGURE: 1 / 1
KCNN3 Antibody (MA5-55478) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of Daudi cells using KCNN3 Recombinant Monoclonal Antibody (Product # MA5-55478) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.
Product Details
MA5-55478
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
7I9R3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 630-730 of human KCNN3/SK3.
Conjugate
Form
Liquid
Concentration
1.55 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
Immunogen Sequence: DLSKMQNVMY DLITELNDRS EDLEKQIGSL ESKLEHLTAS FNSLPLLIAD TLRQQQQQLL SAIIEARGVS VAVGTTHTPI SDSPIGVSST SFPTPYTSSS S
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KCa2.3; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; SK3; SKCa 3; small conductance calcium-activated potassium channel 3; Small conductance calcium-activated potassium channel protein 3
Gene Aliases: hSK3; K3; KCa2.3; KCNN3; SK3; SKCA3
UniProt ID: (Human) Q9UGI6
Entrez Gene ID: (Human) 3782
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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