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Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system. Studies have shown that KCNQ3 and KCNQ5 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy. Voltage-dependent potassium channels are key regulators of the resting membrane potential and modulate the excitability of electrically active cells. The channels are usually tetrameric and can interact with auxiliary subunits that enhance or modify currents mediated by the pore-forming subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: KQT-like 5; KvLQT5; potassium channel protein; Potassium channel subunit alpha KvLQT5; potassium channel, voltage gated KQT-like subfamily Q, member 5; Potassium voltage-gated channel subfamily KQT member 5; potassium voltage-gated channel, KQT-like subfamily, member 5; potassium voltage-gated channel, subfamily Q, member 5; rCG_43583; Voltage-gated potassium channel subunit Kv7.5; voltage-gated potassium channel type Kv7.5
Gene Aliases: 7730402H11; 9230107O05Rik; AA589396; D1Mgi1; KCNQ5; Kcnq5l; Kv7.5
UniProt ID: (Human) Q9NR82, (Mouse) Q9JK45
Entrez Gene ID: (Human) 56479, (Mouse) 226922, (Rat) 259273
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