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Product Details
MA5-17106
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F10B6
Immunogen
Purified recombinant fragment of human KEAP1 (amino acids: 380-624) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. not determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2538577
Product Specific Information
MA5-17106 targets KEAP1 in indirect ELISA, FACS, ICC, IF and WB applications and shows reactivity with Human and Mouse samples.
The MA5-17106 immunogen is purified recombinant fragment of human KEAP1 (amino acids: 380-624) expressed in E. Coli.
MA5-17106 detects KEAP1 which has a predicted molecular weight of approximately 69.7kDa.
Target Information
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cytosolic inhibitor of Nrf2; INrf2; Kelch-like ECH-associated protein 1; kelch-like family member 19; Kelch-like protein 19; NRF2 cytosolic inhibitor; ring canal protein
Gene Aliases: INRF2; KEAP1; KIAA0132; KLHL19; mKIAA0132
UniProt ID: (Human) Q14145, (Mouse) Q9Z2X8
Entrez Gene ID: (Human) 9817, (Mouse) 50868
in utero embryonic development
selenium compound metabolic process
malate metabolic process
transcription, DNA-templated
flavonoid metabolic process
response to metal ion
proteasomal ubiquitin-independent protein catabolic process
negative regulation of gene expression
protein ubiquitination
alkanesulfonate metabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
response to immobilization stress
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
cytoplasmic sequestering of transcription factor
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of epidermal cell differentiation
protein oligomerization
cellular response to interleukin-4
cellular response to organic cyclic compound
response to thyroid hormone
regulation of transcription, DNA-templated
positive regulation of cellular protein metabolic process
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