Product References
Dysregulated Gln-Glu-α-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage.
Cell reports. Medicine
Tang L,Xu XH,Xu S,Liu Z,He Q,Li W,Sun J,Shuai W,Mao J,Zhao JY,Jin L
Tue May 16 00:00:00 EDT 2023
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis.
Nature metabolism
Park G,Haley JA,Le J,Jung SM,Fitzgibbons TP,Korobkina ED,Li H,Fluharty SM,Chen Q,Spinelli JB,Trivedi CM,Jang C,Guertin DA
Sat Jul 01 00:00:00 EDT 2023
Degradation of HIF-1α induced by curcumol blocks glutaminolysis and inhibits epithelial-mesenchymal transition and invasion in colorectal cancer cells.
Cell biology and toxicology
Bian Y,Yin G,Wang G,Liu T,Liang L,Yang X,Zhang W,Tang D
Sun Oct 01 00:00:00 EDT 2023
Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis.
Molecular metabolism
Xiang Z,Bai L,Zhou JQ,Cevallos RR,Sanders JR,Liu G,Bernard K,Sanders YY
Sun Jan 01 00:00:00 EST 2023
MicroRNA-376b-3p Suppresses Choroidal Neovascularization by Regulating Glutaminolysis in Endothelial Cells.
Investigative ophthalmology & visual science
Feng Y,Wang L,Dong C,Yang X,Wang J,Zhang X,Yuan Y,Dai J,Huang J,Yuan F
Tue Jan 03 00:00:00 EST 2023
Exploiting metabolic vulnerabilities after anti-VEGF antibody therapy in ovarian cancer.
iScience
Glassman D,Kim MS,Spradlin M,Badal S,Taki M,Bhattacharya P,Dutta P,Kingsley CV,Foster KI,Animasahun O,Jeon JH,Achreja A,Jayaraman A,Kumar P,Nenwani M,Wuchu F,Bayraktar E,Wu Y,Stur E,Mangala L,Lee S,Yap TA,Westin SN,Eberlin LS,Nagrath D,Sood AK
Fri Feb 17 00:00:00 EST 2023
Inhibition of glutaminolysis ameliorates lupus by regulating T and B cell subsets and downregulating the mTOR/P70S6K/4EBP1 and NLRP3/caspase-1/IL-1β pathways in MRL/lpr mice.
International immunopharmacology
Zhang X,Wang G,Bi Y,Jiang Z,Wang X
Tue Nov 01 00:00:00 EDT 2022
The mTOR/PGC-1α/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells.
Microbiology spectrum
Fu X,Li K,Niu Y,Lin Q,Liang H,Luo X,Liu L,Li N
Wed Feb 23 00:00:00 EST 2022
c-Abl tyrosine kinase inhibition attenuate oxidative stress-induced pancreatic β-Cell dysfunction via glutathione antioxidant system.
Translational research : the journal of laboratory and clinical medicine
Karunakaran U,Elumalai S,Moon JS,Won KC
Tue Nov 01 00:00:00 EDT 2022
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Journal of immunology (Baltimore, Md. : 1950)
Fan TW,Daneshmandi S,Cassel TA,Uddin MB,Sledziona J,Thompson PT,Lin P,Higashi RM,Lane AN
Tue Nov 01 00:00:00 EDT 2022
Bergenin, a PPARγ agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis.
Acta pharmacologica Sinica
Yang L,Zheng Y,Miao YM,Yan WX,Geng YZ,Dai Y,Wei ZF
Fri Apr 01 00:00:00 EDT 2022
Mitochondrial GCN5L1 regulates glutaminase acetylation and hepatocellular carcinoma.
Clinical and translational medicine
Zhang T,Cui Y,Wu Y,Meng J,Han L,Zhang J,Zhang C,Yang C,Chen L,Bai X,Zhang K,Wu K,Sack MN,Wang L,Zhu L
Sun May 01 00:00:00 EDT 2022
Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells.
Cell reports
Choudhury D,Rong N,Ikhapoh I,Rajabian N,Tseropoulos G,Wu Y,Mehrotra P,Thiyagarajan R,Shahini A,Seldeen KL,Troen BR,Lei P,Andreadis ST
Tue Nov 29 00:00:00 EST 2022
Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells.
Cell reports
Choudhury D,Rong N,Ikhapoh I,Rajabian N,Tseropoulos G,Wu Y,Mehrotra P,Thiyagarajan R,Shahini A,Seldeen KL,Troen BR,Lei P,Andreadis ST
Tue Nov 29 00:00:00 EST 2022
Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells.
Cell reports
Choudhury D,Rong N,Ikhapoh I,Rajabian N,Tseropoulos G,Wu Y,Mehrotra P,Thiyagarajan R,Shahini A,Seldeen KL,Troen BR,Lei P,Andreadis ST
Tue Nov 29 00:00:00 EST 2022
Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells.
Cell reports
Choudhury D,Rong N,Ikhapoh I,Rajabian N,Tseropoulos G,Wu Y,Mehrotra P,Thiyagarajan R,Shahini A,Seldeen KL,Troen BR,Lei P,Andreadis ST
Tue Nov 29 00:00:00 EST 2022
Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells.
Cell reports
Choudhury D,Rong N,Ikhapoh I,Rajabian N,Tseropoulos G,Wu Y,Mehrotra P,Thiyagarajan R,Shahini A,Seldeen KL,Troen BR,Lei P,Andreadis ST
Tue Nov 29 00:00:00 EST 2022
Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells.
Cell reports
Choudhury D,Rong N,Ikhapoh I,Rajabian N,Tseropoulos G,Wu Y,Mehrotra P,Thiyagarajan R,Shahini A,Seldeen KL,Troen BR,Lei P,Andreadis ST
Tue Nov 29 00:00:00 EST 2022
Caveolin-1 and Its Functional Peptide CSP7 Affect Silica-Induced Pulmonary Fibrosis by Regulating Fibroblast Glutaminolysis.
Toxicological sciences : an official journal of the Society of Toxicology
Li G,Xu Q,Cheng D,Sun W,Liu Y,Ma D,Wang Y,Zhou S,Ni C
Thu Oct 27 00:00:00 EDT 2022
The mitochondrial enzyme FAHD1 regulates complex II activity in breast cancer cells and is indispensable for basal BT-20 cells in vitro.
FEBS letters
Holzknecht M,Guerrero-Navarro L,Petit M,Albertini E,Damisch E,Simonini A,Schmitt F,Parson W,Fiegl H,Weiss A,Jansen-Duerr P
Tue Nov 01 00:00:00 EDT 2022
Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer's disease.
Translational neurodegeneration
Morrone CD,Lai AY,Bishay J,Hill ME,McLaurin J
Tue May 03 00:00:00 EDT 2022
Morin inhibits the transformation of fibroblasts towards myofibroblasts through regulating "PPAR-γ-glutaminolysis-DEPTOR" pathway in pulmonary fibrosis.
The Journal of nutritional biochemistry
Miao Y,Geng Y,Yang L,Zheng Y,Dai Y,Wei Z
Tue Mar 01 00:00:00 EST 2022
Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment.
Med (New York, N.Y.)
Sponagel J,Jones JK,Frankfater C,Zhang S,Tung O,Cho K,Tinkum KL,Gass H,Nunez E,Spitz DR,Chinnaiyan P,Schaefer J,Patti GJ,Graham MS,Mauguen A,Grkovski M,Dunphy MP,Krebs S,Luo J,Rubin JB,Ippolito JE
Fri Nov 11 00:00:00 EST 2022
Inhibition of glutaminase 1-mediated glutaminolysis improves pathological cardiac remodeling.
American journal of physiology. Heart and circulatory physiology
Yoshikawa S,Nagao M,Toh R,Shinohara M,Iino T,Irino Y,Nishimori M,Tanaka H,Satomi-Kobayashi S,Ishida T,Hirata KI
Sun May 01 00:00:00 EDT 2022
Mandarin Fish (Siniperca chuatsi) p53 Regulates Glutaminolysis Induced by Virus via the p53/miR145-5p/c-Myc Pathway in Chinese Perch Brain Cells.
Microbiology spectrum
Ye C,Liu S,Li N,Zuo S,Niu Y,Lin Q,Liang H,Luo X,Fu X
Wed Apr 27 00:00:00 EDT 2022
A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients.
Aging
Wu X,Sheng H,Wang L,Xia P,Wang Y,Yu L,Lv W,Hu J
Fri Mar 26 00:00:00 EDT 2021
Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure.
Scientific reports
Jones B,Balasubramaniam M,Lebowitz JJ,Taylor A,Villalta F,Khoshbouei H,Grueter C,Grueter B,Dash C,Pandhare J
Thu Jan 14 00:00:00 EST 2021
Brain network reorganization after targeted attack at a hub region.
NeuroImage
Tu W,Ma Z,Zhang N
Sun Aug 15 00:00:00 EDT 2021
Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system.
Redox biology
Karunakaran U,Elumalai S,Moon JS,Won KC
Wed Sep 01 00:00:00 EDT 2021
Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system.
Redox biology
Karunakaran U,Elumalai S,Moon JS,Won KC
Wed Sep 01 00:00:00 EDT 2021
Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system.
Redox biology
Karunakaran U,Elumalai S,Moon JS,Won KC
Wed Sep 01 00:00:00 EDT 2021
Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system.
Redox biology
Karunakaran U,Elumalai S,Moon JS,Won KC
Wed Sep 01 00:00:00 EDT 2021
Maternal high sugar and fat diet benefits offspring brain function via targeting on the gut-brain axis.
Aging
Wang D,Zhang H,Zeng M,Tang X,Zhu X,Guo Y,Qi L,Xie Y,Zhang M,Chen D
Fri Mar 26 00:00:00 EDT 2021
Compound 968 reverses adriamycin resistance in breast cancer MCF-7ADR cells via inhibiting P-glycoprotein function independently of glutaminase.
Cell death discovery
Yang R,Guo Z,Zhao Y,Ma L,Li B,Yang C
Thu Aug 05 00:00:00 EDT 2021
Compound 968 reverses adriamycin resistance in breast cancer MCF-7ADR cells via inhibiting P-glycoprotein function independently of glutaminase.
Cell death discovery
Yang R,Guo Z,Zhao Y,Ma L,Li B,Yang C
Thu Aug 05 00:00:00 EDT 2021
Mitochondrial Metabolism behind Region-Specific Resistance to Ischemia-Reperfusion Injury in Gerbil Hippocampus. Role of PKCβII and Phosphate-Activated Glutaminase.
International journal of molecular sciences
Beręsewicz-Haller M,Krupska O,Bochomulski P,Dudzik D,Chęcińska A,Hilgier W,Barbas C,Zablocki K,Zablocka B
Sat Aug 07 00:00:00 EDT 2021
Andrographolide prevents bone loss via targeting estrogen-related receptor-α-regulated metabolic adaption of osteoclastogenesis.
British journal of pharmacology
Huang T,Fu X,Wang N,Yang M,Zhang M,Wang B,Chen T,Majaz S,Wang H,Wong CW,Liu J,Guan M
Mon Nov 01 00:00:00 EDT 2021
Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex.
Cerebral cortex (New York, N.Y. : 1991)
Sulistomo HW,Nemoto T,Kage Y,Fujii H,Uchida T,Takamiya K,Sumimoto H,Kataoka H,Bito H,Takeya R
Fri Mar 05 00:00:00 EST 2021
Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice.
Cell
Zhou H,Su J,Hu X,Zhou C,Li H,Chen Z,Xiao Q,Wang B,Wu W,Sun Y,Zhou Y,Tang C,Liu F,Wang L,Feng C,Liu M,Li S,Zhang Y,Xu H,Yao H,Shi L,Yang H
Thu Apr 30 00:00:00 EDT 2020
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer.
eLife
Jin H,Wang S,Zaal EA,Wang C,Wu H,Bosma A,Jochems F,Isima N,Jin G,Lieftink C,Beijersbergen R,Berkers CR,Qin W,Bernards R
Mon Oct 05 00:00:00 EDT 2020
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer.
eLife
Jin H,Wang S,Zaal EA,Wang C,Wu H,Bosma A,Jochems F,Isima N,Jin G,Lieftink C,Beijersbergen R,Berkers CR,Qin W,Bernards R
Mon Oct 05 00:00:00 EDT 2020
Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice.
Frontiers in psychiatry
Chen S,Lin Z,Tan KL,Chen R,Su W,Zhao H,Tan Q,Tan W
Thu Oct 22 00:00:00 EDT 2020
Upregulation of GLS1 Isoforms KGA and GAC Facilitates Mitochondrial Metabolism and Cell Proliferation in Epstein-Barr Virus Infected Cells.
Viruses
Krishna G,Soman Pillai V,Valiya Veettil M
Mon Jul 27 00:00:00 EDT 2020
The cross-talk between DDR1 and STAT3 promotes the development of hepatocellular carcinoma.
Aging
Lin Y,Jin H,Wu X,Jian Z,Zou X,Huang J,Guan R,Wei X
Mon Jul 27 00:00:00 EDT 2020
Metabolic reprogramming of glycolysis and glutamine metabolism are key events in myofibroblast transition in systemic sclerosis pathogenesis.
Journal of cellular and molecular medicine
Henderson J,Duffy L,Stratton R,Ford D,O'Reilly S
Tue Dec 01 00:00:00 EST 2020
BPTES inhibits anthrax lethal toxin-induced inflammatory response.
International immunopharmacology
Wang J,Yang D,Shen X,Wang J,Liu X,Lin J,Zhong J,Zhao Y,Qi Z
Sat Aug 01 00:00:00 EDT 2020
Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition.
Cancer & metabolism
Ruiz-Rodado V,Lita A,Dowdy T,Celiku O,Saldana AC,Wang H,Yang CZ,Chari R,Li A,Zhang W,Song H,Zhang M,Ahn S,Davis D,Chen X,Zhuang Z,Herold-Mende C,Walters KJ,Gilbert MR,Larion M
Sun Apr 17 00:00:00 EDT 2022
In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.
Gastroenterology
Wong CC,Xu J,Bian X,Wu JL,Kang W,Qian Y,Li W,Chen H,Gou H,Liu D,Yat Luk ST,Zhou Q,Ji F,Chan LS,Shirasawa S,Sung JJ,Yu J
Tue Dec 01 00:00:00 EST 2020
Anodal and cathodal tDCS modulate neural activity and selectively affect GABA and glutamate syntheses in the visual cortex of cats.
The Journal of physiology
Zhao X,Ding J,Pan H,Zhang S,Pan D,Yu H,Ye Z,Hua T
Tue Sep 01 00:00:00 EDT 2020
Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity.
Molecular cell
Byun JK,Park M,Lee S,Yun JW,Lee J,Kim JS,Cho SJ,Jeon HJ,Lee IK,Choi YK,Park KG
Thu Nov 19 00:00:00 EST 2020
A New Therapeutic Strategy Targeting Protein Deacetylation for Spinal Cord Injury.
Neuroscience
Liu X,Ma B,Zhang H,Chai R,Xiang L
Tue Dec 15 00:00:00 EST 2020
A New Therapeutic Strategy Targeting Protein Deacetylation for Spinal Cord Injury.
Neuroscience
Liu X,Ma B,Zhang H,Chai R,Xiang L
Tue Dec 15 00:00:00 EST 2020
Tissue-Resident Macrophages Promote Renal Cystic Disease.
Journal of the American Society of Nephrology : JASN
Zimmerman KA,Song CJ,Li Z,Lever JM,Crossman DK,Rains A,Aloria EJ,Gonzalez NM,Bassler JR,Zhou J,Crowley MR,Revell DZ,Yan Z,Shan D,Benveniste EN,George JF,Mrug M,Yoder BK
Tue Oct 01 00:00:00 EDT 2019
Glutaminolysis Epigenetically Regulates Antiapoptotic Gene Expression in Idiopathic Pulmonary Fibrosis Fibroblasts.
American journal of respiratory cell and molecular biology
Bai L,Bernard K,Tang X,Hu M,Horowitz JC,Thannickal VJ,Sanders YY
Tue Jan 01 00:00:00 EST 2019
Glutaminolysis Epigenetically Regulates Antiapoptotic Gene Expression in Idiopathic Pulmonary Fibrosis Fibroblasts.
American journal of respiratory cell and molecular biology
Bai L,Bernard K,Tang X,Hu M,Horowitz JC,Thannickal VJ,Sanders YY
Tue Jan 01 00:00:00 EST 2019
Inhibition of Glutaminase 1 Attenuates Experimental Pulmonary Fibrosis.
American journal of respiratory cell and molecular biology
Cui H,Xie N,Jiang D,Banerjee S,Ge J,Sanders YY,Liu G
Tue Oct 01 00:00:00 EDT 2019
Inhibition of Glutaminase 1 Attenuates Experimental Pulmonary Fibrosis.
American journal of respiratory cell and molecular biology
Cui H,Xie N,Jiang D,Banerjee S,Ge J,Sanders YY,Liu G
Tue Oct 01 00:00:00 EDT 2019
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.
Nature communications
Chan K,Robert F,Oertlin C,Kapeller-Libermann D,Avizonis D,Gutierrez J,Handly-Santana A,Doubrovin M,Park J,Schoepfer C,Da Silva B,Yao M,Gorton F,Shi J,Thomas CJ,Brown LE,Porco JA,Pollak M,Larsson O,Pelletier J,Chio IIC
Wed Nov 13 00:00:00 EST 2019
Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake.
OncoTargets and therapy
Zhang P,Wang Q,Lin Z,Yang P,Dou K,Zhang R
Tue Apr 12 00:00:00 EDT 2022
GLS1 promotes proliferation in hepatocellular carcinoma cells via AKT/GSK3β/CyclinD1 pathway.
Experimental cell research
Xi J,Sun Y,Zhang M,Fa Z,Wan Y,Min Z,Xu H,Xu C,Tang J
Thu Aug 01 00:00:00 EDT 2019
Blockade of lncRNA-ASLNCS5088-enriched exosome generation in M2 macrophages by GW4869 dampens the effect of M2 macrophages on orchestrating fibroblast activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Chen J,Zhou R,Liang Y,Fu X,Wang D,Wang C
Fri Nov 01 00:00:00 EDT 2019
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
American journal of respiratory cell and molecular biology
Hamanaka RB,O'Leary EM,Witt LJ,Tian Y,Gökalp GA,Meliton AY,Dulin NO,Mutlu GM
Fri Nov 01 00:00:00 EDT 2019
TNFα increases STAT3-mediated expression of glutaminase isoform KGA in cultured rat astrocytes.
Cytokine
Milewski K,Bogacińska-Karaś M,Hilgier W,Albrecht J,Zielińska M
Fri Nov 01 00:00:00 EDT 2019
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
Cell research
Cai WF,Zhang C,Wu YQ,Zhuang G,Ye Z,Zhang CS,Lin SC
Wed Aug 01 00:00:00 EDT 2018
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
Cell research
Cai WF,Zhang C,Wu YQ,Zhuang G,Ye Z,Zhang CS,Lin SC
Wed Aug 01 00:00:00 EDT 2018
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
Cell research
Cai WF,Zhang C,Wu YQ,Zhuang G,Ye Z,Zhang CS,Lin SC
Wed Aug 01 00:00:00 EDT 2018
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
Cell research
Cai WF,Zhang C,Wu YQ,Zhuang G,Ye Z,Zhang CS,Lin SC
Wed Aug 01 00:00:00 EDT 2018
Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation.
American journal of respiratory cell and molecular biology
Ge J,Cui H,Xie N,Banerjee S,Guo S,Dubey S,Barnes S,Liu G
Thu Mar 01 00:00:00 EST 2018
Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation.
American journal of respiratory cell and molecular biology
Ge J,Cui H,Xie N,Banerjee S,Guo S,Dubey S,Barnes S,Liu G
Thu Mar 01 00:00:00 EST 2018
Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation.
American journal of respiratory cell and molecular biology
Ge J,Cui H,Xie N,Banerjee S,Guo S,Dubey S,Barnes S,Liu G
Thu Mar 01 00:00:00 EST 2018
Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation.
American journal of respiratory cell and molecular biology
Ge J,Cui H,Xie N,Banerjee S,Guo S,Dubey S,Barnes S,Liu G
Thu Mar 01 00:00:00 EST 2018
Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation.
American journal of respiratory cell and molecular biology
Ge J,Cui H,Xie N,Banerjee S,Guo S,Dubey S,Barnes S,Liu G
Thu Mar 01 00:00:00 EST 2018
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Gene
Hu M,Liu L,Yao W
Sat Dec 15 00:00:00 EST 2018
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Gene
Hu M,Liu L,Yao W
Sat Dec 15 00:00:00 EST 2018
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Gene
Hu M,Liu L,Yao W
Sat Dec 15 00:00:00 EST 2018
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Gene
Hu M,Liu L,Yao W
Sat Dec 15 00:00:00 EST 2018
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.
Nature communications
Wang YQ,Wang HL,Xu J,Tan J,Fu LN,Wang JL,Zou TH,Sun DF,Gao QY,Chen YX,Fang JY
Wed Feb 07 00:00:00 EST 2018
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.
Nature communications
Wang YQ,Wang HL,Xu J,Tan J,Fu LN,Wang JL,Zou TH,Sun DF,Gao QY,Chen YX,Fang JY
Wed Feb 07 00:00:00 EST 2018
Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations.
Cell metabolism
Chen Q,Kirk K,Shurubor YI,Zhao D,Arreguin AJ,Shahi I,Valsecchi F,Primiano G,Calder EL,Carelli V,Denton TT,Beal MF,Gross SS,Manfredi G,D'Aurelio M
Tue May 01 00:00:00 EDT 2018
Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation.
The Journal of biological chemistry
Bernard K,Logsdon NJ,Benavides GA,Sanders Y,Zhang J,Darley-Usmar VM,Thannickal VJ
Fri Jan 26 00:00:00 EST 2018
PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC.
Molecular cancer research : MCR
Kim MJ,Choi YK,Park SY,Jang SY,Lee JY,Ham HJ,Kim BG,Jeon HJ,Kim JH,Kim JG,Lee IK,Park KG
Fri Sep 01 00:00:00 EDT 2017
PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC.
Molecular cancer research : MCR
Kim MJ,Choi YK,Park SY,Jang SY,Lee JY,Ham HJ,Kim BG,Jeon HJ,Kim JH,Kim JG,Lee IK,Park KG
Fri Sep 01 00:00:00 EDT 2017
Aging Reduces an ERRalpha-Directed Mitochondrial Glutaminase Expression Suppressing Glutamine Anaplerosis and Osteogenic Differentiation of Mesenchymal Stem Cells.
Stem cells (Dayton, Ohio)
Huang T,Liu R,Fu X,Yao D,Yang M,Liu Q,Lu WW,Wu C,Guan M
Wed Feb 01 00:00:00 EST 2017
Aging Reduces an ERRalpha-Directed Mitochondrial Glutaminase Expression Suppressing Glutamine Anaplerosis and Osteogenic Differentiation of Mesenchymal Stem Cells.
Stem cells (Dayton, Ohio)
Huang T,Liu R,Fu X,Yao D,Yang M,Liu Q,Lu WW,Wu C,Guan M
Wed Feb 01 00:00:00 EST 2017
HIF-2α regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma.
Journal of cellular and molecular medicine
Li W,Chen C,Zhao X,Ye H,Zhao Y,Fu Z,Pan W,Zheng S,Wei L,Nong T,Li Z,Chen R
Wed Nov 01 00:00:00 EDT 2017
HIF-2α regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma.
Journal of cellular and molecular medicine
Li W,Chen C,Zhao X,Ye H,Zhao Y,Fu Z,Pan W,Zheng S,Wei L,Nong T,Li Z,Chen R
Wed Nov 01 00:00:00 EDT 2017
Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cells.
Oncotarget
Munksgaard Thorén M,Vaapil M,Staaf J,Planck M,Johansson ME,Mohlin S,Påhlman S
Tue Jul 25 00:00:00 EDT 2017
Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells.
International journal of cancer
Kahlert UD,Cheng M,Koch K,Marchionni L,Fan X,Raabe EH,Maciaczyk J,Glunde K,Eberhart CG
Tue Mar 01 00:00:00 EST 2016
Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells.
International journal of cancer
Kahlert UD,Cheng M,Koch K,Marchionni L,Fan X,Raabe EH,Maciaczyk J,Glunde K,Eberhart CG
Tue Mar 01 00:00:00 EST 2016
CFIm25 regulates glutaminase alternative terminal exon definition to modulate miR-23 function.
RNA (New York, N.Y.)
Masamha CP,Xia Z,Peart N,Collum S,Li W,Wagner EJ,Shyu AB
Wed Jun 01 00:00:00 EDT 2016
Blocking glutamate carboxypeptidase II inhibits glutamate excitotoxicity and regulates immune responses in experimental autoimmune encephalomyelitis.
The FEBS journal
Ha D,Bing SJ,Ahn G,Kim J,Cho J,Kim A,Herath KH,Yu HS,Jo SA,Cho IH,Jee Y
Thu Sep 01 00:00:00 EDT 2016
Blocking glutamate carboxypeptidase II inhibits glutamate excitotoxicity and regulates immune responses in experimental autoimmune encephalomyelitis.
The FEBS journal
Ha D,Bing SJ,Ahn G,Kim J,Cho J,Kim A,Herath KH,Yu HS,Jo SA,Cho IH,Jee Y
Thu Sep 01 00:00:00 EDT 2016
Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.
Cell cycle (Georgetown, Tex.)
Pérez-Escuredo J,Dadhich RK,Dhup S,Cacace A,Van Hée VF,De Saedeleer CJ,Sboarina M,Rodriguez F,Fontenille MJ,Brisson L,Porporato PE,Sonveaux P
Thu Oct 13 00:00:00 EDT 2016
Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.
Cell cycle (Georgetown, Tex.)
Pérez-Escuredo J,Dadhich RK,Dhup S,Cacace A,Van Hée VF,De Saedeleer CJ,Sboarina M,Rodriguez F,Fontenille MJ,Brisson L,Porporato PE,Sonveaux P
Thu Oct 13 00:00:00 EDT 2016
Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.
Toxicological sciences : an official journal of the Society of Toxicology
Nault R,Fader KA,Kirby MP,Ahmed S,Matthews J,Jones AD,Lunt SY,Zacharewski TR
Mon Feb 01 00:00:00 EST 2016
Glutaminolysis Was Induced by TGF-β1 through PP2Ac Regulated Raf-MEK-ERK Signaling in Endothelial Cells.
PloS one
Guo Y,Deng Y,Li X,Ning Y,Lin X,Guo S,Chen M,Han M
Fri Aug 11 00:00:00 EDT 2017
Glutaminolysis Was Induced by TGF-β1 through PP2Ac Regulated Raf-MEK-ERK Signaling in Endothelial Cells.
PloS one
Guo Y,Deng Y,Li X,Ning Y,Lin X,Guo S,Chen M,Han M
Fri Aug 11 00:00:00 EDT 2017
Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival.
Scientific reports
Fuchsberger T,Martínez-Bellver S,Giraldo E,Teruel-Martí V,Lloret A,Viña J
Fri Aug 12 00:00:00 EDT 2016
Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival.
Scientific reports
Fuchsberger T,Martínez-Bellver S,Giraldo E,Teruel-Martí V,Lloret A,Viña J
Fri Aug 12 00:00:00 EDT 2016
Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival.
Scientific reports
Fuchsberger T,Martínez-Bellver S,Giraldo E,Teruel-Martí V,Lloret A,Viña J
Fri Aug 12 00:00:00 EDT 2016
Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival.
Scientific reports
Fuchsberger T,Martínez-Bellver S,Giraldo E,Teruel-Martí V,Lloret A,Viña J
Fri Aug 12 00:00:00 EDT 2016
Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch.
Oncotarget
Lee SY,Jeon HM,Ju MK,Jeong EK,Kim CH,Park HG,Han SI,Kang HS
Tue Feb 16 00:00:00 EST 2016
Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch.
Oncotarget
Lee SY,Jeon HM,Ju MK,Jeong EK,Kim CH,Park HG,Han SI,Kang HS
Tue Feb 16 00:00:00 EST 2016
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Cell research
Sun L,Song L,Wan Q,Wu G,Li X,Wang Y,Wang J,Liu Z,Zhong X,He X,Shen S,Pan X,Li A,Wang Y,Gao P,Tang H,Zhang H
Wed Apr 01 00:00:00 EDT 2015
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Cell research
Sun L,Song L,Wan Q,Wu G,Li X,Wang Y,Wang J,Liu Z,Zhong X,He X,Shen S,Pan X,Li A,Wang Y,Gao P,Tang H,Zhang H
Wed Apr 01 00:00:00 EDT 2015
Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.
The Journal of clinical investigation
Karner CM,Esen E,Okunade AL,Patterson BW,Long F
Sun Feb 01 00:00:00 EST 2015
Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.
The Journal of clinical investigation
Karner CM,Esen E,Okunade AL,Patterson BW,Long F
Sun Feb 01 00:00:00 EST 2015
A small subunit processome protein promotes cancer by altering translation.
Oncogene
Yang HW,Kim TM,Song SS,Menon L,Jiang X,Huang W,Black PM,Park PJ,Carroll RS,Johnson MD
Thu Aug 20 00:00:00 EDT 2015
A small subunit processome protein promotes cancer by altering translation.
Oncogene
Yang HW,Kim TM,Song SS,Menon L,Jiang X,Huang W,Black PM,Park PJ,Carroll RS,Johnson MD
Thu Aug 20 00:00:00 EDT 2015
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression.
Nature
Masamha CP,Xia Z,Yang J,Albrecht TR,Li M,Shyu AB,Li W,Wagner EJ
Thu Jun 19 00:00:00 EDT 2014
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression.
Nature
Masamha CP,Xia Z,Yang J,Albrecht TR,Li M,Shyu AB,Li W,Wagner EJ
Thu Jun 19 00:00:00 EDT 2014
Modulation of immune function by glutamatergic neurons in the cerebellar interposed nucleus via hypothalamic and sympathetic pathways.
Brain, behavior, and immunity
Xu FF,Huang Y,Wang XQ,Qiu YH,Peng YP
Thu May 01 00:00:00 EDT 2014
Modulation of immune function by glutamatergic neurons in the cerebellar interposed nucleus via hypothalamic and sympathetic pathways.
Brain, behavior, and immunity
Xu FF,Huang Y,Wang XQ,Qiu YH,Peng YP
Thu May 01 00:00:00 EDT 2014
The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
Cancer research
Corbet C,Draoui N,Polet F,Pinto A,Drozak X,Riant O,Feron O
Wed Oct 01 00:00:00 EDT 2014
The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
Cancer research
Corbet C,Draoui N,Polet F,Pinto A,Drozak X,Riant O,Feron O
Wed Oct 01 00:00:00 EDT 2014
A cell engineering strategy to enhance the safety of stem cell therapies.
Cell reports
Oricchio E,Papapetrou EP,Lafaille F,Ganat YM,Kriks S,Ortega-Molina A,Mark WH,Teruya-Feldstein J,Huse JT,Reuter V,Sadelain M,Studer L,Wendel HG
Thu Sep 25 00:00:00 EDT 2014
A cell engineering strategy to enhance the safety of stem cell therapies.
Cell reports
Oricchio E,Papapetrou EP,Lafaille F,Ganat YM,Kriks S,Ortega-Molina A,Mark WH,Teruya-Feldstein J,Huse JT,Reuter V,Sadelain M,Studer L,Wendel HG
Thu Sep 25 00:00:00 EDT 2014
FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.
The EMBO journal
Yeo H,Lyssiotis CA,Zhang Y,Ying H,Asara JM,Cantley LC,Paik JH
Wed Oct 02 00:00:00 EDT 2013
FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.
The EMBO journal
Yeo H,Lyssiotis CA,Zhang Y,Ying H,Asara JM,Cantley LC,Paik JH
Wed Oct 02 00:00:00 EDT 2013
Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism.
Molecular autism
Shimmura C,Suzuki K,Iwata Y,Tsuchiya KJ,Ohno K,Matsuzaki H,Iwata K,Kameno Y,Takahashi T,Wakuda T,Nakamura K,Hashimoto K,Mori N
Tue Mar 26 00:00:00 EDT 2013
Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism.
Molecular autism
Shimmura C,Suzuki K,Iwata Y,Tsuchiya KJ,Ohno K,Matsuzaki H,Iwata K,Kameno Y,Takahashi T,Wakuda T,Nakamura K,Hashimoto K,Mori N
Tue Mar 26 00:00:00 EDT 2013
Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Cell
Garcia-Cao I,Song MS,Hobbs RM,Laurent G,Giorgi C,de Boer VC,Anastasiou D,Ito K,Sasaki AT,Rameh L,Carracedo A,Vander Heiden MG,Cantley LC,Pinton P,Haigis MC,Pandolfi PP
Fri Mar 30 00:00:00 EDT 2012
Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Cell
Garcia-Cao I,Song MS,Hobbs RM,Laurent G,Giorgi C,de Boer VC,Anastasiou D,Ito K,Sasaki AT,Rameh L,Carracedo A,Vander Heiden MG,Cantley LC,Pinton P,Haigis MC,Pandolfi PP
Fri Mar 30 00:00:00 EDT 2012
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.
Proceedings of the National Academy of Sciences of the United States of America
Liu W,Le A,Hancock C,Lane AN,Dang CV,Fan TW,Phang JM
Tue Jun 05 00:00:00 EDT 2012
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.
Proceedings of the National Academy of Sciences of the United States of America
Liu W,Le A,Hancock C,Lane AN,Dang CV,Fan TW,Phang JM
Tue Jun 05 00:00:00 EDT 2012
The NF-κB member p65 controls glutamine metabolism through miR-23a.
The international journal of biochemistry & cell biology
Rathore MG,Saumet A,Rossi JF,de Bettignies C,Tempé D,Lecellier CH,Villalba M
Sat Sep 01 00:00:00 EDT 2012
The NF-κB member p65 controls glutamine metabolism through miR-23a.
The international journal of biochemistry & cell biology
Rathore MG,Saumet A,Rossi JF,de Bettignies C,Tempé D,Lecellier CH,Villalba M
Sat Sep 01 00:00:00 EDT 2012
Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance.
Cancer biology & therapy
Ko YH,Lin Z,Flomenberg N,Pestell RG,Howell A,Sotgia F,Lisanti MP,Martinez-Outschoorn UE
Thu Dec 15 00:00:00 EST 2011
Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance.
Cancer biology & therapy
Ko YH,Lin Z,Flomenberg N,Pestell RG,Howell A,Sotgia F,Lisanti MP,Martinez-Outschoorn UE
Thu Dec 15 00:00:00 EST 2011
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
Colombo SL,Palacios-Callender M,Frakich N,De Leon J,Schmitt CA,Boorn L,Davis N,Moncada S
Tue Nov 02 00:00:00 EDT 2010
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
Colombo SL,Palacios-Callender M,Frakich N,De Leon J,Schmitt CA,Boorn L,Davis N,Moncada S
Tue Nov 02 00:00:00 EDT 2010
