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Immunogen sequence: DLSLAPRIS GTVCLSVPQP SPYQVIGCSG FHLSSLYP (201-237 aa encoded by BC022080)
KHDC1 family members are K-homology (KH) domain-containing RNA binding proteins that are involved in various aspects of RNA metabolism, ranging from transcription to RNA splicing, transportation, translation, and stability. KHDC1 is highly expressed in oocytes and interacts with cytoplasmic polyadenylation element-binding protein 1 (CPEB1), a key translational regulator controlling the polyA length of mRNAs. KHDC1 functions as a global translational repressor and induces apoptosis through an ER-dependent signaling pathway and that the C-terminal putative trans-membrane motif (TMM) is critical for its activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: KH homology domain-containing protein 1; MGC10818
Gene Aliases: bA257K9.4; C6orf147; C6orf148; Em:AC019205.8; KHDC1; NDG1
UniProt ID: (Human) Q4VXA5
Entrez Gene ID: (Human) 80759
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