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KHDC1 family members are K-homology (KH) domain-containing RNA binding proteins that are involved in various aspects of RNA metabolism, ranging from transcription to RNA splicing, transportation, translation, and stability. KHDC1 is highly expressed in oocytes and interacts with cytoplasmic polyadenylation element-binding protein 1 (CPEB1), a key translational regulator controlling the polyA length of mRNAs. KHDC1 functions as a global translational repressor and induces apoptosis through an ER-dependent signaling pathway and that the C-terminal putative trans-membrane motif (TMM) is critical for its activities.
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Protein Aliases: KH homology domain containing 1A; KH homology domain-containing protein 1; KH homology domain-containing protein 1A; MGC10818; Nur77 downstream gene 1 protein; Nur77 downstream protein 1
Gene Aliases: AU014713; bA257K9.4; C6orf147; C6orf148; C88118; Em:AC019205.8; KHDC1; Khdc1a; NDG1
UniProt ID: (Human) Q4VXA5, (Mouse) Q3UWR2
Entrez Gene ID: (Human) 80759, (Mouse) 368204
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