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KIR3DL1 Antibody (PA5-120247) in WB
Western blot analysis of KIR3DL1 in extracts of Rat thymus. Samples were incubated with KIR3DL1 Polyclonal antibody (Product # PA5-120247) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-120247
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 22-222 of human KIR3DL1 (NP_037421.2).
Conjugate
Form
Liquid
Concentration
4.05 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2913819
Product Specific Information
Positive test controls include: Rat thymus. The target is usually found in the following locations: Cell membrane, Single-pass type I membrane protein.
Target Information
KIR3DL1 are Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13. 4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3DL1; AMB11; CD158 antigen-like family member E; CD158e; CD158e antigen; CD158E1/2; CD158E2; HLA-BW4-specific inhibitory NK cell receptor; Killer cell immunoglobulin-like receptor 3DL1; killer cell immunoglobulin-like receptor three domains long cytoplasmic tail 2; killer cell immunoglobulin-like receptor three domains short cytoplasmic tail 1; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1; killer Ig receptor; KIR antigen 3DL1; KIR G1; KIR3D; KIR3DS1; MGC119726; MGC119728; MGC126589; MGC126591; MHC class I NK cell receptor; natural killer cell receptor; Natural killer-associated transcript 3; NK receptor; NK-receptor; NKAT-3; NKAT10; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clones CL-2/CL-11; p70 NK; p70 NK receptor CL-2/CL-11
Gene Aliases: CD158E; CD158E1; KIR; KIR3DL1; KIR3DL1/S1; KIR3DL2; NKAT-3; NKAT3; NKB1; NKB1B
UniProt ID: (Human) P43629, (Rat) P83556
Entrez Gene ID: (Human) 3811, (Rat) 353253
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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