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Product Details
H00003814-M03
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1D11
Immunogen
KISS1 (NP_002247, 46 a.a. approximately 145 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.44 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: PGEQSLPCTE RKPAATARLS RRGTSLSPPP ESSGSPQQPG LSAPHSRQIP APQGAVLVQR EKDLPNYNWN SFGLRFGKRE AAPGNHGRSA GRGWGAGAGQ
Target Information
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH neurons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Kisspeptin-1; malignant melanoma metastasis-suppressor; Metastasis-suppressor KiSS-1; metastin; prepro-kisspeptin
Gene Aliases: HH13; KiSS-1; KISS1; PP5098
UniProt ID: (Human) Q15726
Entrez Gene ID: (Human) 3814
cytoskeleton organization
negative regulation of cell proliferation
positive regulation of luteinizing hormone secretion
positive regulation of MAPK cascade
positive regulation of synaptic transmission
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
generation of ovulation cycle rhythm
positive regulation of growth hormone secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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