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Product Details
H00007071-M46
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2H5
Immunogen
KLF10 (AAH11538.1, 1 a.a. approximately 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MEERMEMISE RPKESMYSWN KTAEKSDFEA VEALMSMSCS WKSDFKKYVE NRPVTPVSDL SEEENLLPGT PDFHTIPAFC LTPPYSPSDF EPSQVSNLMA PAPSTVHFKS
Target Information
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. KLF10 is a transcriptional repressor involved in the regulation of cell growth and inhibits cell growth. It binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta thus playing a role in linking TGF-beta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth. KLF10 is involved in inducing and promoting apoptosis through the mitochondrial apoptotic pathway and may inhibit Smad7 expression in bronchial epithelial cells. Ubiquitous expression of KLF10 is seen in most of the tissues. Reports suggest that it may mediate up-regulation of TGFBI in VHL-deficient tumors and other cancers. Over expression of KLF10 may be associated with renal clear cell carcinoma and other tumors. KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: early growth response-alpha; EGR-alpha; Krueppel-like factor 10; Kruppel-like factor 10; TGFB-inducible early growth response protein 1; Transforming growth factor-beta-inducible early growth response protein 1; zinc finger transcription factor TIEG
Gene Aliases: EGR-alpha; EGRA; KLF10; TIEG; TIEG1
UniProt ID: (Human) Q13118
Entrez Gene ID: (Human) 7071
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
transcription, DNA-templated
transforming growth factor beta receptor signaling pathway
cell-cell signaling
circadian rhythm
cell proliferation
negative regulation of cell proliferation
cellular response to starvation
bone mineralization
somatic stem cell population maintenance
regulation of circadian rhythm
positive regulation of osteoclast differentiation
negative regulation of transcription, DNA-templated
cellular response to peptide
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