Proteintech

KLK3/PSA Polyclonal Antibody

KLK3/PSA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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KLK3/PSA Antibody (10679-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using 10679-1-AP ( KLK3/PSA antibody at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Product Image Gallery

Product Details

10679-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:8,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLK3/PSA Fusion Protein Ag1060 (1-261 aa encoded by BC005307)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MWVPVVFLT LSVTWIGAAP LILSRIVGGW ECEKHSQPWQ VLVASRGRAV CGGVLVHPQW VLTAAHCIRN KSVILLGRHS LFHPEDTGQV FQVSHSFPHP LYDMSLLKNR FLRPGDDSSH DLMLLRLSEP AELTDAVKVM DLPTQEPALG TTCYASGWGS IEPEEFLTPK KLQCVDLHVI SNDVCAQVHP QKVTKFMLCA GRWTGGKSTC SGDSGGPLVC NGVLQGITSW GSEPCALPER PSLYTKVVHY RKWIKDTIVA NP (1-261 aa encoded by BC005307)

Target Information

PSA is a chymotrypsin-like serine protease (kallikrein family) produced by the prostate epithelium, and is abundant in seminal fluid. PSA can be detected in the sera of patients with prostatic carcinoma. It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). A higher proportion of serum PSA is complexed to ACT in prostate cancer than in benign prostate hyperplasia. PSA is used to confirm prostatic acinar cell origin in primary and metastatic carcinoma and to rule out non-prostatic carcinoma mimics.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.

Molecular biology reports

Erzurumlu Y,Dogan HK,Catakli D

Wed Feb 01 00:00:00 EST 2023

RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression.

Cell death & disease

Zhou T,Wang S,Song X,Liu W,Dong F,Huo Y,Zou R,Wang C,Zhang S,Liu W,Sun G,Lin L,Zeng K,Dong X,Guo Q,Yi F,Wang Z,Li X,Jiang B,Cao L,Zhao Y

Fri Apr 15 00:00:00 EDT 2022

Quercetin in Tonglong Qibi decoction ameliorates testosterone-induced benign prostatic hyperplasia in rats by regulating Nrf2 signalling pathways and oxidative stress.

Andrologia

Fu W,Chen S,Zhang Z,Chen Y,You X,Li Q

Sat Oct 01 00:00:00 EDT 2022

Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover.

Cancer & metabolism

Raftopulos NL,Washaya TC,Niederprüm A,Egert A,Hakeem-Sanni MF,Varney B,Aishah A,Georgieva ML,Olsson E,Dos Santos DZ,Nassar ZD,Cochran BJ,Nagarajan SR,Kakani MS,Hastings JF,Croucher DR,Rye KA,Butler LM,Grewal T,Hoy AJ

Sat Jan 15 00:00:00 EST 2022

Expansion of mouse castration-resistant intermediate prostate stem cells in vitro.

Stem cell research & therapy

Xu Y,Mu J,Zhou Z,Leng Y,Yu Y,Song X,Liu A,Zhu H,Li J,Wang D

Fri Jul 15 00:00:00 EDT 2022

Expansion of mouse castration-resistant intermediate prostate stem cells in vitro.

Stem cell research & therapy

Xu Y,Mu J,Zhou Z,Leng Y,Yu Y,Song X,Liu A,Zhu H,Li J,Wang D

Fri Jul 15 00:00:00 EDT 2022

Correction: Expansion of mouse castration-resistant intermediate prostate stem cells in vitro.

Stem cell research & therapy

Xu Y,Mu J,Zhou Z,Leng Y,Yu Y,Song X,Liu A,Zhu H,Li J,Wang D

Fri Nov 25 00:00:00 EST 2022

Correction: Expansion of mouse castration-resistant intermediate prostate stem cells in vitro.

Stem cell research & therapy

Xu Y,Mu J,Zhou Z,Leng Y,Yu Y,Song X,Liu A,Zhu H,Li J,Wang D

Fri Nov 25 00:00:00 EST 2022

α-Terthienyl induces prostate cancer cell death through inhibiting androgen receptor expression.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Gan X,Huang H,Wen J,Liu K,Yang Y,Li X,Fang G,Liu Y,Wang X

Mon Aug 01 00:00:00 EDT 2022

NCAPD3 promotes prostate cancer progression by up-regulating EZH2 and MALAT1 through STAT3 and E2F1.

Cellular signalling

Jing Z,Liu Q,Xie W,Wei Y,Liu J,Zhang Y,Zuo W,Lu S,Zhu Q,Liu P

Fri Apr 01 00:00:00 EDT 2022

Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.

Clinical and translational medicine

Zhou L,Zhang C,Yang X,Liu L,Hu J,Hou Y,Tao H,Sugimura H,Chen Z,Wang L,Chen K

Tue Jun 01 00:00:00 EDT 2021

A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth.

eLife

Gillis JL,Hinneh JA,Ryan NK,Irani S,Moldovan M,Quek LE,Shrestha RK,Hanson AR,Xie J,Hoy AJ,Holst J,Centenera MM,Mills IG,Lynn DJ,Selth LA,Butler LM

Thu Aug 12 00:00:00 EDT 2021

KAT2A-mediated AR translocation into nucleus promotes abiraterone-resistance in castration-resistant prostate cancer.

Cell death & disease

Lu D,Song Y,Yu Y,Wang D,Liu B,Chen L,Li X,Li Y,Cheng L,Lv F,Zhang P,Xing Y

Thu Aug 12 00:00:00 EDT 2021

KAT2A-mediated AR translocation into nucleus promotes abiraterone-resistance in castration-resistant prostate cancer.

Cell death & disease

Lu D,Song Y,Yu Y,Wang D,Liu B,Chen L,Li X,Li Y,Cheng L,Lv F,Zhang P,Xing Y

Thu Aug 12 00:00:00 EDT 2021

PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells.

International journal of biological sciences

Liu W,Wang C,Wang S,Zeng K,Wei S,Sun N,Sun G,Wang M,Zou R,Liu W,Lin L,Song H,Jin Z,Zhao Y

Mon Jan 03 00:00:00 EST 2022

ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3.

Theranostics

Zhou L,Song Z,Hu J,Liu L,Hou Y,Zhang X,Yang X,Chen K

Wed Aug 04 00:00:00 EDT 2021

KLF5 Is Crucial for Androgen-AR Signaling to Transactivate Genes and Promote Cell Proliferation in Prostate Cancer Cells.

Cancers

Li J,Zhang B,Liu M,Fu X,Ci X,A J,Fu C,Dong G,Wu R,Zhang Z,Fu L,Dong JT

Sat Mar 21 00:00:00 EDT 2020

Wnt5a induces and maintains prostate cancer cells dormancy in bone.

The Journal of experimental medicine

Ren D,Dai Y,Yang Q,Zhang X,Guo W,Ye L,Huang S,Chen X,Lai Y,Du H,Lin C,Peng X,Song L

Mon Feb 04 00:00:00 EST 2019

Wnt5a induces and maintains prostate cancer cells dormancy in bone.

The Journal of experimental medicine

Ren D,Dai Y,Yang Q,Zhang X,Guo W,Ye L,Huang S,Chen X,Lai Y,Du H,Lin C,Peng X,Song L

Mon Feb 04 00:00:00 EST 2019

Identification of reciprocal microRNA-mRNA pairs associated with metastatic potential disparities in human prostate cancer cells and signaling pathway analysis.

Journal of cellular biochemistry

Ma H,Wang LY,Yang RH,Zhou Y,Zhou P,Kong L

Tue Oct 01 00:00:00 EDT 2019

The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer.

Molecular cancer therapeutics

Tran LNK,Kichenadasse G,Butler LM,Centenera MM,Morel KL,Ormsby RJ,Michael MZ,Lower KM,Sykes PJ

Fri Dec 01 00:00:00 EST 2017

The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer.

Molecular cancer therapeutics

Tran LNK,Kichenadasse G,Butler LM,Centenera MM,Morel KL,Ormsby RJ,Michael MZ,Lower KM,Sykes PJ

Fri Dec 01 00:00:00 EST 2017

Bioinformatics

Protein Aliases: Antigen; Gamma-seminoprotein; Kallikrein 3; Kallikrein-3; Kallikrein-3 (KLK3); kallikrein-related peptidase 3; KLK-3; P-30 antigen; prostate specific antigen; prostate-specific (APS); Prostate-specific antigen; PSA; Semenogelase; Seminin

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Gene Aliases: APS; hK3; KLK2A1; KLK3; PSA

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UniProt ID: (Human) P07288

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Entrez Gene ID: (Human) 354

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Function(s)

endopeptidase activity serine-type endopeptidase activity protein binding serine-type peptidase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides protease serine protease protein modifying enzyme

Process(es)

antibacterial peptide production proteolysis negative regulation of angiogenesis cellular protein metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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KLK3/PSA Polyclonal Antibody

KLK3/PSA Antibody (10679-1-AP) in IHC (P)

Product Details

10679-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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