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Product Details
H00003845-M05
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG3, kappa
Class
Monoclonal
Type
Antibody
Clone
1E4-1B10
Immunogen
KRAS (AAH13572, 1 a.a. approximately 188 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG HEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QDLARSYGIP FIETSAKTRQ GVDDAFYTLV REIRKHKEKM SKDGKKKKKK SKTKCVIM
Target Information
K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. It plays an important role in the regulation of cell proliferation and has a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner. Mutations in the gene can result in leukemia acute myelogenous, leukemia juvenile myelomonocytic, Noonan Syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-K-ras; c-Ki-ras; c-Kirsten-ras protein; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; GTPase KRas; K RAS; K-Ras 2; K-ras p21 protein; Ki-Ras; Kirsten rat sarcoma viral oncogene homolog; oncogene KRAS2; PR310 c-K-ras oncogene; RASK; transforming protein p21; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog
Gene Aliases: C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS; KRAS1; KRAS2; NS; NS3; RALD; RASK2
UniProt ID: (Human) P01116
Entrez Gene ID: (Human) 3845
MAPK cascade
positive regulation of protein phosphorylation
stimulatory C-type lectin receptor signaling pathway
epidermal growth factor receptor signaling pathway
Ras protein signal transduction
axon guidance
positive regulation of cell proliferation
visual learning
positive regulation of gene expression
cytokine-mediated signaling pathway
forebrain astrocyte development
actin cytoskeleton organization
regulation of protein stability
regulation of synaptic transmission, GABAergic
positive regulation of Rac protein signal transduction
social behavior
endocrine signaling
Fc-epsilon receptor signaling pathway
ERBB2 signaling pathway
positive regulation of MAP kinase activity
negative regulation of neuron apoptotic process
negative regulation of cell differentiation
regulation of long-term neuronal synaptic plasticity
homeostasis of number of cells within a tissue
leukocyte migration
positive regulation of nitric-oxide synthase activity
positive regulation of NF-kappaB transcription factor activity
striated muscle cell differentiation
response to glucocorticoid
response to mineralocorticoid
epithelial tube branching involved in lung morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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