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Product Details
APC-004-200UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GST fusion protein with the sequence HRETDHEEQAALKEEQGIQRRESGLDTGGQRKVSCSKASFHKTGGPLEST DSIRRGSCPLEKCHLKAKSNVDLRRSLYALCLDTS RETDL, corresponding to amino acid residues 513-602 of mouse KV1.5, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 5% sucrose, 1% BSA
Contains
0.025% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
In neurons voltage-dependent potassium channels are key determinants of the resting membrane potential and of membrane excitability, conditioning the frequency, and shape of action potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cardiac potassium channel; HPCN1; insulinoma and islet potassium channel; KV1-5; MGC117058; MGC117059; Potassium (K+) channel protein alpha 5; potassium channel 1; potassium channel, voltage gated shaker related subfamily A, member 5; potassium voltage gated channel, shaker related subfamily, member 5; Potassium voltage-gated channel subfamily A member 5; potassium voltage-gated channel, shaker-related subfamily, member 5; RCK7; RK4; Voltage-gated potassium channel HK2; voltage-gated potassium channel protein Kv1.5; Voltage-gated potassium channel subunit Kv1.5
Gene Aliases: ATFB7; HCK1; HK2; HPCN1; KCNA5; Kv1; KV1.5; PCN1
UniProt ID: (Human) P22460, (Rat) P19024, (Mouse) Q61762
Entrez Gene ID: (Human) 3741, (Rat) 25470, (Mouse) 16493
receptor binding
delayed rectifier potassium channel activity
protein binding
outward rectifier potassium channel activity
potassium channel inhibitor activity
protein kinase binding
alpha-actinin binding
voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in SA node cell action potential repolarization
scaffold protein binding
voltage-gated potassium channel activity
ion channel activity
voltage-gated ion channel activity
potassium channel activity
voltage-gated ion channel
response to hypoxia
potassium ion transport
Notch signaling pathway
response to mechanical stimulus
response to organic substance
regulation of vasoconstriction
regulation of membrane potential
response to hydrogen peroxide
regulation of potassium ion transport
negative regulation of potassium ion transport
regulation of insulin secretion
protein homooligomerization
negative regulation of cytosolic calcium ion concentration
potassium ion homeostasis
response to hyperoxia
membrane hyperpolarization
regulation of atrial cardiac muscle cell membrane repolarization
potassium ion export
potassium ion transmembrane transport
atrial cardiac muscle cell action potential
membrane repolarization during bundle of His cell action potential
membrane repolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of myoblast proliferation
protein oligomerization
transport
ion transport
regulation of ion transmembrane transport
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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