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This target displays homology in the following species: Dog: 86%; Human: 100%; Mouse: 93%; Pig: 86%; Rabbit: 77%; Rat: 93%
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
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Protein Aliases: AF4/FMR2 family member 3; AF4/FMR2 family, member 3; lymphoid nuclear protein 4; Lymphoid nuclear protein related to AF4; MLLT2-related protein; Protein LAF-4
Gene Aliases: AFF3; LAF4; MLLT2-like
UniProt ID: (Human) P51826
Entrez Gene ID: (Human) 3899
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