Proteintech

LAMP1 Polyclonal Antibody

LAMP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 7

LAMP1 Antibody (21997-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 21997-1-AP ( LAMP1 antibody at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Product Image Gallery

Product Details

21997-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 59 publications 59 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 30 publications 30 publications

Flow Cytometry (Flow)

Assay-dependent

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Reptile

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LAMP1 Fusion Protein Ag17367 (35-377 aa encoded by BC021288)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.48 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NGNGTACIM ANFSAAFSVN YDTKSGPKNM TFDLPSDATV VLNRSSCGKE NTSDPSLVIA FGRGHTLTLN FTRNATRYSV QLMSFVYNLS DTHLFPNASS KEIKTVESIT DIRADIDKKY RCVSGTQVHM NNVTVTLHDA TIQAYLSNSS FSRGETRCEQ DRPSPTTAPP APPSPSPSPV PKSPSVDKYN VSGTNGTCLL ASMGLQLNLT YERKDNTTVT RLLNINPNKT SASGSCGAHL VTLELHSEGT TVLLFQFGMN ASSSRFFLQG IQLNTILPDA RDPAFKAANG SLRALQATVG NSYKCNAEEH VRVTKAFSVN IFKVWVQAFK VEGGQFGSVE ECLL (35-377 aa encoded by BC021288)

Target Information

LAMP1 (CD107a, lysosome-associated membrane protein-1) together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. LAMP1 is a heavily glycosylated membrane protein which contains a putative signal peptide, 18 sites for N-linked glycosylation, a single membrane-spanning segment and a short (11 amino acid) cytosolic tail. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. LAMP1 is a type 1 integral membrane protein that is transported from trans-Golgi network to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboyxl-terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1, and this mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 (and LAMP2) have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore, they are possibly involved in the adhesion of PBMC to the site of inflammation. Increased LAMP1 immunoreactivity is observed in neurons and glial cells surrounding senile plaques in Alzheimer’s Disease (AD) cases, and is localized in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. LAMP1 is a good marker of mast cell activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Dual targets of lethal apoptosis and protective autophagy in liver cancer with periplocymarin elicit a limited therapeutic effect.

International journal of oncology

Hao Y,Song T,Wang M,Li T,Zhao C,Li T,Hou Y,He H

Wed Mar 01 00:00:00 EST 2023

Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming.

Cell death & disease

Liu Z,Fan M,Hou J,Pan S,Xu Y,Zhang H,Liu C,Hao X,Li X,Wang H

Mon Feb 20 00:00:00 EST 2023

PPARγ inhibited tumor immune escape by inducing PD-L1 autophagic degradation.

Cancer science

Gou Q,Che S,Chen M,Chen H,Shi J,Hou Y

Sat Jul 01 00:00:00 EDT 2023

PPARγ agonist pioglitazone enhances colorectal cancer immunotherapy by inducing PD-L1 autophagic degradation.

European journal of pharmacology

Jia X,Qian J,Chen H,Liu Q,Hussain S,Jin J,Shi J,Hou Y

Wed Jul 05 00:00:00 EDT 2023

Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.

Environmental toxicology

Yu H,Hao Z,Liu X,Wei Z,Tan R,Liu X,Chen Q,Chen Y,Zhou H,Liu Y,Fu Z

Fri Sep 01 00:00:00 EDT 2023

Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.

Environmental toxicology

Yu H,Hao Z,Liu X,Wei Z,Tan R,Liu X,Chen Q,Chen Y,Zhou H,Liu Y,Fu Z

Fri Sep 01 00:00:00 EDT 2023

Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.

Environmental toxicology

Yu H,Hao Z,Liu X,Wei Z,Tan R,Liu X,Chen Q,Chen Y,Zhou H,Liu Y,Fu Z

Fri Sep 01 00:00:00 EDT 2023

Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.

Environmental toxicology

Yu H,Hao Z,Liu X,Wei Z,Tan R,Liu X,Chen Q,Chen Y,Zhou H,Liu Y,Fu Z

Fri Sep 01 00:00:00 EDT 2023

Polyphyllin D punctures hypertrophic lysosomes to reverse drug resistance of hepatocellular carcinoma by targeting acid sphingomyelinase.

Molecular therapy : the journal of the American Society of Gene Therapy

Wang Y,Chen YY,Gao GB,Zheng YH,Yu NN,Ouyang L,Gao X,Li N,Wen SY,Huang S,Zhao Q,Liu L,Cao M,Zhang S,Zhang J,He QY

Wed Jul 05 00:00:00 EDT 2023

Discovery of Small-Molecule Degraders for Alpha-Synuclein Aggregates.

Journal of medicinal chemistry

Tong Y,Zhu W,Chen J,Wen T,Xu F,Pang J

Thu Jun 22 00:00:00 EDT 2023

Canine distemper virus N protein induces autophagy to facilitate viral replication.

BMC veterinary research

Chen F,Guo Z,Zhang R,Zhang Z,Hu B,Bai L,Zhao S,Wu Y,Zhang Z,Li Y

Wed Mar 15 00:00:00 EDT 2023

Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjögren's Disease.

Arthritis & rheumatology (Hoboken, N.J.)

Nakamura H,Tanaka T,Zheng C,Afione SA,Warner BM,Noguchi M,Atsumi T,Chiorini JA

Fri Sep 01 00:00:00 EDT 2023

A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB.

Proceedings of the National Academy of Sciences of the United States of America

Lin Y,Shi Q,Yang G,Shi F,Zhou Y,Wang T,Xu P,Li P,Liu Z,Sun H,Zhao Z,Ding K,Wang Z,Feng H,Yu B,Fang P,Wang J

Tue Feb 14 00:00:00 EST 2023

Apigenin Alleviated High-Fat-Diet-Induced Hepatic Pyroptosis by Mitophagy-ROS-CTSB-NLRP3 Pathway in Mice and AML12 Cells.

Journal of agricultural and food chemistry

Meng Z,Gao M,Wang C,Guan S,Zhang D,Lu J

Wed May 10 00:00:00 EDT 2023

Ethyl Gallate Inhibits Bovine Viral Diarrhea Virus by Promoting IFITM3 Expression, Lysosomal Acidification and Protease Activity.

International journal of molecular sciences

Zhang L,Yang G,Wang J,Zhang J,Chen K,Xiong X,Zhu Y,Xu C,Wang J

Fri May 12 00:00:00 EDT 2023

DR region of NKAα1 is a target to ameliorate hepatic lipid metabolism disturbance in obese mice.

Metabolism: clinical and experimental

Sun HJ,Tan JX,Shan XD,Wang ZC,Wu ZY,Bian JS,Nie XW

Tue Aug 01 00:00:00 EDT 2023

The lysosome-mitochondrion crosstalk engaged in silver nanoparticles-disturbed mitochondrial homeostasis.

The Science of the total environment

Liu J,Huang Z,Yin S,Zhou X,Jiang Y,Shao L

Fri Sep 01 00:00:00 EDT 2023

LAMP3 transfer via extracellular particles induces apoptosis in Sjögren's disease.

Scientific reports

Tanaka T,Nakamura H,Tran DT,Warner BM,Wang Y,Atsumi T,Noguchi M,Chiorini JA

Tue Feb 14 00:00:00 EST 2023

Capsaicin alleviates cisplatin-induced muscle loss and atrophy in vitro and in vivo.

Journal of cachexia, sarcopenia and muscle

Huang KC,Chiang YF,Huang TC,Chen HY,Lin PH,Ali M,Hsia SM

Wed Feb 01 00:00:00 EST 2023

PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle.

Cell reports

Hara M,Wu W,Malechka VV,Takahashi Y,Ma JX,Moiseyev G

Tue Feb 28 00:00:00 EST 2023

Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjögren's disease.

PloS one

Nakamura H,Tanaka T,Ji Y,Zheng C,Afione SA,Warner BM,Oliveira FR,Motta ACF,Rocha EM,Noguchi M,Atsumi T,Chiorini JA

Mon Feb 27 00:00:00 EST 2023

Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjögren's disease.

PloS one

Nakamura H,Tanaka T,Ji Y,Zheng C,Afione SA,Warner BM,Oliveira FR,Motta ACF,Rocha EM,Noguchi M,Atsumi T,Chiorini JA

Mon Feb 27 00:00:00 EST 2023

Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjögren's disease.

PloS one

Nakamura H,Tanaka T,Ji Y,Zheng C,Afione SA,Warner BM,Oliveira FR,Motta ACF,Rocha EM,Noguchi M,Atsumi T,Chiorini JA

Mon Feb 27 00:00:00 EST 2023

Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjögren's disease.

PloS one

Nakamura H,Tanaka T,Ji Y,Zheng C,Afione SA,Warner BM,Oliveira FR,Motta ACF,Rocha EM,Noguchi M,Atsumi T,Chiorini JA

Mon Feb 27 00:00:00 EST 2023

Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H⁺-driven lysosomal pyridoxine exporter.

Life science alliance

Akino S,Yasujima T,Yamashiro T,Yuasa H

Wed Feb 01 00:00:00 EST 2023

FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.

Autophagy

Cai W,Hu M,Li C,Wu R,Lu D,Xie C,Zhang W,Li T,Shen S,Huang H,Qiu W,Liu Q,Lu Y,Lu Z

Sat Apr 01 00:00:00 EDT 2023

TFEB coordinates autophagy and pyroptosis as hepatotoxicity responses to ZnO nanoparticles.

The Science of the total environment

Pei X,Liu D,Li J,Li L,Ding X,Zhang W,Li Z,Xu G,Li C,Li D

Mon Mar 20 00:00:00 EDT 2023

Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy.

Virus research

Wang J,Yang G,Zhang L,Zhang J,Wang J,Zou Y,Wang J

Tue Nov 01 00:00:00 EDT 2022

Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy.

Virus research

Wang J,Yang G,Zhang L,Zhang J,Wang J,Zou Y,Wang J

Tue Nov 01 00:00:00 EDT 2022

Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.

Journal of hazardous materials

Kang Y,Yin S,Liu J,Jiang Y,Huang Z,Chen L,Shao L

Tue Feb 15 00:00:00 EST 2022

Rhodiola activates macrophage migration inhibitory factor to alleviate non-alcoholic fatty liver disease.

Life sciences

Liu J,Li D,Dun Y,Li H,Ripley-Gonzalez JW,Zhang J,Qiu L,You B,Liu S

Tue Nov 01 00:00:00 EDT 2022

Multi-omics analysis unravels dysregulated lysosomal function and lipid metabolism involved in sub-chronic particulate matter-induced pulmonary injury.

The Science of the total environment

Yan L,Chen S,Hou C,Lin J,Xiong W,Shen Y,Zhou T

Thu Aug 25 00:00:00 EDT 2022

A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation.

Journal of neurochemistry

Aring L,Choi EK,Kopera H,Lanigan T,Iwase S,Klionsky DJ,Seo YA

Tue Feb 01 00:00:00 EST 2022

Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways.

Scientific reports

Miyahara H,Hasegawa K,Yashiro M,Ohara T,Fujisawa M,Yoshimura T,Matsukawa A,Tsukahara H

Mon Mar 21 00:00:00 EDT 2022

LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization.

Autophagy

Tanaka T,Warner BM,Michael DG,Nakamura H,Odani T,Yin H,Atsumi T,Noguchi M,Chiorini JA

Fri Jul 01 00:00:00 EDT 2022

LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization.

Autophagy

Tanaka T,Warner BM,Michael DG,Nakamura H,Odani T,Yin H,Atsumi T,Noguchi M,Chiorini JA

Fri Jul 01 00:00:00 EDT 2022

GRN-/- iPSC-derived cortical neurons recapitulate the pathological findings of both frontotemporal lobar degeneration and neuronal ceroidolipofuscinosis.

Neurobiology of disease

Bossolasco P,Cimini S,Maderna E,Bardelli D,Canafoglia L,Cavallaro T,Ricci M,Silani V,Marucci G,Rossi G

Thu Dec 01 00:00:00 EST 2022

TMEΜ45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits Viral Replication.

Journal of virology

Yan F,Yang W,Wang X,Gao G

Wed Sep 14 00:00:00 EDT 2022

SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.

Environmental toxicology

Zhao Y,Mao A,Zhang R,Guan S,Lu J

Tue Mar 01 00:00:00 EST 2022

Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene-deleted mice.

British journal of pharmacology

Ma C,Wu H,Yang G,Xiang J,Feng K,Zhang J,Hua Y,Kang L,Fan G,Yang S

Sat Jan 01 00:00:00 EST 2022

Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene-deleted mice.

British journal of pharmacology

Ma C,Wu H,Yang G,Xiang J,Feng K,Zhang J,Hua Y,Kang L,Fan G,Yang S

Sat Jan 01 00:00:00 EST 2022

Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene-deleted mice.

British journal of pharmacology

Ma C,Wu H,Yang G,Xiang J,Feng K,Zhang J,Hua Y,Kang L,Fan G,Yang S

Sat Jan 01 00:00:00 EST 2022

Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene-deleted mice.

British journal of pharmacology

Ma C,Wu H,Yang G,Xiang J,Feng K,Zhang J,Hua Y,Kang L,Fan G,Yang S

Sat Jan 01 00:00:00 EST 2022

The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.

iScience

Zhang G,Han J,Wang L,Yang X,Yan Z,Qu M,Zhou H,Bilal H,Wang F,Ge H,Yang X

Fri Apr 15 00:00:00 EDT 2022

PRKX down-regulates TAK1/IRF7 signaling in the antiviral innate immunity of black carp Mylopharyngodon piceus.

Frontiers in immunology

Yang X,Ai Y,Chen L,Wang C,Liu J,Zhang J,Li J,Wu H,Xiao J,Chang M,Feng H

Wed Feb 01 00:00:00 EST 2023

Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.

Stem cell research & therapy

Jin C,Ou Q,Chen J,Wang T,Zhang J,Wang Z,Wang Y,Tian H,Xu JY,Gao F,Wang J,Li J,Lu L,Xu GT

Fri Apr 01 00:00:00 EDT 2022

Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.

Stem cell research & therapy

Jin C,Ou Q,Chen J,Wang T,Zhang J,Wang Z,Wang Y,Tian H,Xu JY,Gao F,Wang J,Li J,Lu L,Xu GT

Fri Apr 01 00:00:00 EDT 2022

Compensatory engulfment and Müller glia reactivity in the absence of microglia.

Glia

Thiel WA,Blume ZI,Mitchell DM

Fri Jul 01 00:00:00 EDT 2022

Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB.

Frontiers in immunology

Chu BX,Li YN,Liu N,Yuan LX,Chen SY,Zhu YH,Wang JF

Mon Feb 14 00:00:00 EST 2022

Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.

Life sciences

Li H,Dun Y,Zhang W,You B,Liu Y,Fu S,Qiu L,Cheng J,Ripley-Gonzalez JW,Liu S

Sat May 15 00:00:00 EDT 2021

GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America

Yuan W,Lu L,Rao M,Huang Y,Liu CE,Liu S,Zhao Y,Liu H,Zhu J,Chao T,Wu C,Ren J,Lv L,Li W,Qi S,Liang Y,Yue S,Gao J,Zhang Z,Kong E

Tue Mar 30 00:00:00 EDT 2021

Metformin attenuates atherosclerosis and plaque vulnerability by upregulating KLF2-mediated autophagy in apoE^-/- mice.

Biochemical and biophysical research communications

Wu H,Feng K,Zhang C,Zhang H,Zhang J,Hua Y,Dong Z,Zhu Y,Yang S,Ma C

Fri Jun 11 00:00:00 EDT 2021

Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.

Autophagy

Wang R,Zhu Y,Ren C,Yang S,Tian S,Chen H,Jin M,Zhou H

Mon Feb 01 00:00:00 EST 2021

Molecular Characterization of AMPA-Receptor-Containing Vesicles.

Frontiers in molecular neuroscience

Peters JJ,Leitz J,Oses-Prieto JA,Burlingame AL,Brunger AT

Thu Nov 18 00:00:00 EST 2021

1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Fan Y,Lu J,Liu J,Zhang R,Yu Z,Guan S

Mon Nov 01 00:00:00 EDT 2021

Human Endogenous Retrovirus (HERV)-K env Gene Knockout Affects Tumorigenic Characteristics of nupr1 Gene in DLD-1 Colorectal Cancer Cells.

International journal of molecular sciences

Ko EJ,Ock MS,Choi YH,Iovanna JL,Mun S,Han K,Kim HS,Cha HJ

Sun Apr 11 00:00:00 EDT 2021

Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer.

Nature communications

Punturi NB,Seker S,Devarakonda V,Mazumder A,Kalra R,Chen CH,Li S,Primeau T,Ellis MJ,Kavuri SM,Haricharan S

Wed May 19 00:00:00 EDT 2021

Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.

International journal of molecular sciences

Wang S,Xu X,Che D,Fan R,Gao M,Cao Y,Ge C,Feng Y,Li J,Xie S,Wang C,Dai F,Gao L,Wang Y

Tue Oct 12 00:00:00 EDT 2021

Circ_0030998 promotes tumor proliferation and angiogenesis by sponging miR-567 to regulate VEGFA in colorectal cancer.

Cell death discovery

Jin L,Han C,Zhai T,Zhang X,Chen C,Lian L

Thu Jun 24 00:00:00 EDT 2021

Identification of Compound CB-2 as a Novel Late-Stage Autophagy Inhibitor Exhibits Inhibitory Potency against A549 Cells.

Life (Basel, Switzerland)

Liu Z,Zhang L,Liu Y,Zhang H,Chen J,Feng G,Yang P,Sha F,Cui L,Sun G

Mon Aug 23 00:00:00 EDT 2021

1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells.

Toxicology

Lu J,Fan Y,Liu M,Zhang Q,Guan S

Fri Apr 30 00:00:00 EDT 2021

WDR45 Mutation Impairs the Autophagic Degradation of Transferrin Receptor and Promotes Ferroptosis.

Frontiers in molecular biosciences

Xiong Q,Li X,Li W,Chen G,Xiao H,Li P,Wu C

Sat May 22 00:00:00 EDT 2021

WDR45 Mutation Impairs the Autophagic Degradation of Transferrin Receptor and Promotes Ferroptosis.

Frontiers in molecular biosciences

Xiong Q,Li X,Li W,Chen G,Xiao H,Li P,Wu C

Sat May 22 00:00:00 EDT 2021

Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.

Neurobiology of disease

Zou L,Zhang X,Xiong M,Meng L,Tian Y,Pan L,Yuan X,Chen G,Wang Z,Bu L,Yao Z,Zhang Z,Ye K,Zhang Z

Thu Jul 01 00:00:00 EDT 2021

Claudin-5 Affects Endothelial Autophagy in Response to Early Hypoxia.

Frontiers in physiology

Yu P,Li Y,Zhong G,Li W,Chen B,Zhang J

Sat Sep 18 00:00:00 EDT 2021

Thioxothiazolidin derivative, 4-OST, inhibits melanogenesis by enhancing the specific recruitment of tyrosinase-containing vesicles to lysosome.

Journal of cellular biochemistry

Isogawa K,Asano M,Hayazaki M,Koga K,Watanabe M,Suzuki K,Kobayashi T,Kawaguchi K,Ishizuka A,Kato S,Ito H,Hamamoto A,Koyama H,Furuta K,Takemori H

Tue Jun 01 00:00:00 EDT 2021

Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.

Archives of pharmacal research

Wang J,Su Q,Wu Q,Chen K,Ullah A,Ghauri MA,Zhang Y

Mon Nov 01 00:00:00 EDT 2021

Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.

Archives of pharmacal research

Wang J,Su Q,Wu Q,Chen K,Ullah A,Ghauri MA,Zhang Y

Mon Nov 01 00:00:00 EDT 2021

Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation.

Cell death & disease

Zhang Z,Mou Z,Xu C,Wu S,Dai X,Chen X,Ou Y,Chen Y,Yang C,Jiang H

Sat Aug 07 00:00:00 EDT 2021

TFEB Promotes Prostate Cancer Progression via Regulating ABCA2-Dependent Lysosomal Biogenesis.

Frontiers in oncology

Zhu X,Zhuo Y,Wu S,Chen Y,Ye J,Deng Y,Feng Y,Liu R,Cai S,Zou Z,Wang B,Wu CL,Zeng G,Zhong W

Thu Oct 21 00:00:00 EDT 2021

The N-glycosylation of Equine Tetherin Affects Antiviral Activity by Regulating Its Subcellular Localization.

Viruses

Bai B,Wang XF,Zhang M,Na L,Zhang X,Zhang H,Yang Z,Wang X

Sun Feb 16 00:00:00 EST 2020

Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.

Aging cell

Mao K,Chen J,Yu H,Li H,Ren Y,Wu X,Wen Y,Zou F,Li W

Mon Jun 01 00:00:00 EDT 2020

mTORC1-dependent TFEB nucleus translocation and pro-survival autophagy induced by zeolitic imidazolate framework-8.

Biomaterials science

Ding H,Song Y,Huang X,Wang L,Luo S,Zhang H,Pan H,Jiang W,Qian J,Yao G,Wen L,Zhang Y

Tue Jul 28 00:00:00 EDT 2020

The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation.

Journal of virology

Zheng Y,Zhu G,Yan J,Tang Y,Han S,Yin J,Peng B,He X,Liu W

Tue Mar 17 00:00:00 EDT 2020

Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation.

Aging

Tang D,Liu X,Chen K,Li Z,Dai Y,Xu J,Zhang HT,Gao X,Liu L

Sat Jun 27 00:00:00 EDT 2020

Butyrate-mediated autophagy inhibition limits cytosolic Salmonella Infantis replication in the colon of pigs treated with a mixture of Lactobacillus and Bacillus.

Veterinary research

Chu B,Zhu Y,Su J,Xia B,Zou Y,Nie J,Zhang W,Wang J

Wed Aug 05 00:00:00 EDT 2020

Butyrate-mediated autophagy inhibition limits cytosolic Salmonella Infantis replication in the colon of pigs treated with a mixture of Lactobacillus and Bacillus.

Veterinary research

Chu B,Zhu Y,Su J,Xia B,Zou Y,Nie J,Zhang W,Wang J

Wed Aug 05 00:00:00 EDT 2020

Meg3 Induces EMT and Invasion of Glioma Cells via Autophagy.

OncoTargets and therapy

Yang Z,Bian E,Xu Y,Ji X,Tang F,Ma C,Wang H,Zhao B

Thu Jul 21 00:00:00 EDT 2022

Identification and functional characterization of interferon-γ-inducible lysosomal thiol reductase (GILT) gene in common Chinese cuttlefish Sepiella japonica.

Fish & shellfish immunology

Pang Z,Zhang Y,Liu L

Fri Mar 01 00:00:00 EST 2019

Identification and functional characterization of interferon-γ-inducible lysosomal thiol reductase (GILT) gene in common Chinese cuttlefish Sepiella japonica.

Fish & shellfish immunology

Pang Z,Zhang Y,Liu L

Fri Mar 01 00:00:00 EST 2019

Sufentanil impairs autophagic degradation and inhibits cell migration in NCI-H460 in vitro.

Oncology letters

Jiang H,Wang H,Zou W,Hu Y,Chen C,Wang C

Sun Dec 01 00:00:00 EST 2019

Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk.

Cell proliferation

Sheng J,Shen L,Sun L,Zhang X,Cui R,Wang L

Wed May 01 00:00:00 EDT 2019

Pyrroloquinoline quinine ameliorates doxorubicin-induced autophagy-dependent apoptosis via lysosomal-mitochondrial axis in vascular endothelial cells.

Toxicology

Jiang C,Jiang L,Li Q,Liu X,Zhang T,Yang G,Zhang C,Wang N,Sun X,Jiang L

Sun Sep 01 00:00:00 EDT 2019

Novel half-sandwich iridium OˆC (carbene)-Complexes: In vitro and in vivo tumor growth suppression and pro-apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes.

Cancer letters

Xu Z,Zhang Y,Zhang S,Jia X,Zhong G,Yang Y,Du Q,Li J,Liu Z

Wed Apr 10 00:00:00 EDT 2019

Circular RNA profiling provides insights into their subcellular distribution and molecular characteristics in HepG2 cells.

RNA biology

Zhang J,Zhang X,Li C,Yue L,Ding N,Riordan T,Yang L,Li Y,Jen C,Lin S,Zhou D,Chen F

Fri Feb 01 00:00:00 EST 2019

Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes.

Oxidative medicine and cellular longevity

Wu X,Sun R,Wang H,Yang B,Wang F,Xu H,Chen S,Zhao R,Pi J,Xu Y

Mon Apr 20 00:00:00 EDT 2020

Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy.

Cells

Hussain T,Zhao D,Shah SZA,Sabir N,Wang J,Liao Y,Song Y,Dong H,Hussain Mangi M,Ni J,Yang L,Zhou X

Sun May 26 00:00:00 EDT 2019

Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy.

Cells

Hussain T,Zhao D,Shah SZA,Sabir N,Wang J,Liao Y,Song Y,Dong H,Hussain Mangi M,Ni J,Yang L,Zhou X

Sun May 26 00:00:00 EDT 2019

Dysregulated autophagy as a new aspect of the molecular pathogenesis of Krabbe disease.

Neurobiology of disease

Del Grosso A,Angella L,Tonazzini I,Moscardini A,Giordano N,Caleo M,Rocchiccioli S,Cecchini M

Sun Sep 01 00:00:00 EDT 2019

LncRNA expression profile during autophagy and Malat1 function in macrophages.

PloS one

Ma Z,Zhang J,Xu X,Qu Y,Dong H,Dang J,Huo Z,Xu G

Thu Apr 02 00:00:00 EDT 2020

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.

Immunity

Deng M,Tang Y,Li W,Wang X,Zhang R,Zhang X,Zhao X,Liu J,Tang C,Liu Z,Huang Y,Peng H,Xiao L,Tang D,Scott MJ,Wang Q,Liu J,Xiao X,Watkins S,Li J,Yang H,Wang H,Chen F,Tracey KJ,Billiar TR,Lu B

Tue Oct 16 00:00:00 EDT 2018

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.

Immunity

Deng M,Tang Y,Li W,Wang X,Zhang R,Zhang X,Zhao X,Liu J,Tang C,Liu Z,Huang Y,Peng H,Xiao L,Tang D,Scott MJ,Wang Q,Liu J,Xiao X,Watkins S,Li J,Yang H,Wang H,Chen F,Tracey KJ,Billiar TR,Lu B

Tue Oct 16 00:00:00 EDT 2018

Differential signaling pathways are initiated in macrophages during infection depending on the intracellular fate of Chlamydia spp.

Immunology and cell biology

Nagarajan UM,Tripathy M,Kollipara A,Allen J,Goodwin A,Whittimore J,Wyrick PB,Rank RG

Thu Mar 01 00:00:00 EST 2018

Differential signaling pathways are initiated in macrophages during infection depending on the intracellular fate of Chlamydia spp.

Immunology and cell biology

Nagarajan UM,Tripathy M,Kollipara A,Allen J,Goodwin A,Whittimore J,Wyrick PB,Rank RG

Thu Mar 01 00:00:00 EST 2018

Molecular and biological characterization of gamma-interferon-inducible lysosomal thiol reductase in silver carp (Hypophthalmichthys molitrix).

Fish & shellfish immunology

Cao F,Wu H,Lv T,Yang Y,Li Y,Liu S,Hu L,Xu X,Ma L,Zhang X,Li J,Bi X,Gu W,Zhang S

Wed Aug 01 00:00:00 EDT 2018

Acetyl-CoA Synthetase 2 Promotes Cell Migration and Invasion of Renal Cell Carcinoma by Upregulating Lysosomal-Associated Membrane Protein 1 Expression.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Yao L,Guo X,Gui Y

Mon Mar 19 00:00:00 EDT 2018

Acetyl-CoA Synthetase 2 Promotes Cell Migration and Invasion of Renal Cell Carcinoma by Upregulating Lysosomal-Associated Membrane Protein 1 Expression.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Yao L,Guo X,Gui Y

Mon Mar 19 00:00:00 EDT 2018

LIN28A inhibits lysosome‑associated membrane glycoprotein 1 protein expression in embryonic stem and bladder cancer cells.

Molecular medicine reports