Proteintech

LAMP2 Polyclonal Antibody

LAMP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

LAMP2 Antibody (27823-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver tissue slide using (Product # 27823-1-AP) (LAMP2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Product Image Gallery

Product Details

27823-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 24 publications 24 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

View 15 publications 15 publications

Product Specifications

Species Reactivity

Human, Pig

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LAMP2 Fusion Protein Ag27183 (29-230 aa encoded by BC002965)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.47 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LELNLTDSE NATCLYAKWQ MNFTVRYETT NKTYKTVTIS DHGTVTYNGS ICGDDQNGPK IAVQFGPGFS WIANFTKAAS TYSIDSVSFS YNTGDNTTFP DAEDKGILTV DELLAIRIPL NDLFRCNSLS TLEKNDVVQH YWDVLVQAFV QNGTVSTNEF LCDKDKTSTV APTIHTTVPS PTTTPTPKEK PEAGTYSVNN GND (29-230 aa encoded by BC002965)

Target Information

LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. Prior to posttranslational modification, LAMP2 is approximately 46 kDa polypeptide. Mature, functional LAMP2 is extensively glycosylated with a variety of different N-linked and O-linked oligosaccharides with a total molecular weight of about 100-130 kDa. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. LAMP2 is used to monitor a very selective form of autophagy called chaperone-mediated autophagy. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. The LAMP protein has 3 variant forms: LAMP-2A, -2B, and 2C. LAMP2, together with CD107a/LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, and LAMP2 is an important regulator in successful phagosomal maturation. LAMP2 deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danon’s disease).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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25-hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.

Veterinary microbiology

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25-hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.

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Cell death & disease

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Bioinformatics

Protein Aliases: CD107 antigen-like family member B; CD107b; Igp96; LAMP-2; LAMP-2 Isoform 2A; LAMP-2 Variant A; LGP-96; lysosomal-associated membrane protein 2; Lysosome-associated membrane glycoprotein 2; RP23-193O17.2

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Gene Aliases: CD107b; LAMP-2; LAMP2; LAMPB; LGP110

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UniProt ID: (Human) P13473

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Entrez Gene ID: (Pig) 100154598, (Human) 3920

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Function(s)

protein binding enzyme binding protein domain specific binding membrane trafficking regulatory protein

Process(es)

platelet degranulation protein import regulation of protein stability muscle cell cellular homeostasis protein stabilization chaperone-mediated autophagy

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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LAMP2 Polyclonal Antibody

LAMP2 Antibody (27823-1-AP) in IHC (P)

Product Details

27823-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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