Proteintech

LAMP2 Monoclonal Antibody (2D3B9)

LAMP2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 16

LAMP2 Antibody (66301-1-IG) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using (Product # 66301-1-IG) (LAMP2 antibody), at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L), phalloidin stains F-actin (red).

LAMP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

66301-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 46 publications 46 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 30 publications 30 publications

Immunoprecipitation (IP)

View 2 publications 2 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Pig

Published species

Mouse

Host/Isotype

Mouse / IgA

Class

Monoclonal

Type

Antibody

Clone

2D3B9

Immunogen

LAMP2 Fusion Protein Ag0595 (255-390 aa encoded by BC002965)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.7 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NPNTTHSTG SCRSHTALLR LNSSTIKYLD FVFAVKNENR FYLKEVNISM YLVNGSVFSI ANNNLSYWDA PLGSSYMCNK EQTVSVSGAF QINTFDLRVQ PFNVTQGKYS TAQECSLDDD TILIPIIVGA GLSGLII (255-390 aa encoded by BC002965 )

Target Information

LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. Prior to posttranslational modification, LAMP2 is approximately 46 kDa polypeptide. Mature, functional LAMP2 is extensively glycosylated with a variety of different N-linked and O-linked oligosaccharides with a total molecular weight of about 100-130 kDa. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. LAMP2 is used to monitor a very selective form of autophagy called chaperone-mediated autophagy. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. The LAMP protein has 3 variant forms: LAMP-2A, -2B, and 2C. LAMP2, together with CD107a/LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, and LAMP2 is an important regulator in successful phagosomal maturation. LAMP2 deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danon’s disease).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming.

Cell death & disease

Liu Z,Fan M,Hou J,Pan S,Xu Y,Zhang H,Liu C,Hao X,Li X,Wang H

Mon Feb 20 00:00:00 EST 2023

Stromal cell-derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin-8-induced autophagy.

Journal of extracellular vesicles

Wang X,Xu F,Kou H,Zheng Y,Yang J,Xu Z,Fang Y,Sun W,Zhu S,Jiang Q,Wei X,Xu Y

Sat Jul 01 00:00:00 EDT 2023

Stromal cell-derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin-8-induced autophagy.

Journal of extracellular vesicles

Wang X,Xu F,Kou H,Zheng Y,Yang J,Xu Z,Fang Y,Sun W,Zhu S,Jiang Q,Wei X,Xu Y

Sat Jul 01 00:00:00 EDT 2023

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.

Autophagy

Zheng W,Chen Q,Liu H,Zeng L,Zhou Y,Liu X,Bai Y,Zhang J,Pan Y,Shao C

Wed Mar 01 00:00:00 EST 2023

Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition.

The Journal of experimental medicine

Chu Q,An J,Liu P,Song Y,Zhai X,Yang R,Niu J,Yang C,Li B

Mon Mar 06 00:00:00 EST 2023

Autophagic response of intestinal epithelial cells exposed to polystyrene nanoplastics.

Environmental toxicology

Xu X,Feng Y,Han C,Yao Z,Liu Y,Luo C,Sheng J

Sun Jan 01 00:00:00 EST 2023

Cadmium-induced impairment of spermatozoa development by reducing exosomal-MVBs secretion: a novel pathway.

Aging

Ali W,Bian Y,Ali H,Sun J,Zhu J,Ma Y,Liu Z,Zou H

Tue Apr 25 00:00:00 EDT 2023

Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjögren's Disease.

Arthritis & rheumatology (Hoboken, N.J.)

Nakamura H,Tanaka T,Zheng C,Afione SA,Warner BM,Noguchi M,Atsumi T,Chiorini JA

Fri Sep 01 00:00:00 EDT 2023

Autophagy and exosomes coordinately mediate quercetin's protective effects on alcoholic liver disease.

The Journal of nutritional biochemistry

Chen H,Liu J,Peng S,Yang G,Cheng X,Chen L,Zhang H,Zhao Y,Yao P,Tang Y

Thu Jun 01 00:00:00 EDT 2023

RAB7A GTPase Is Involved in Mitophagosome Formation and Autophagosome-Lysosome Fusion in N2a Cells Treated with the Prion Protein Fragment 106-126.

Molecular neurobiology

Li Z,Lai M,Li J,Yang D,Zhao M,Wang D,Sun Z,Wen P,Gou F,Dai Y,Ji Y,Zhao D,Qiao J,Yang L

Wed Mar 01 00:00:00 EST 2023

RAB7A GTPase Is Involved in Mitophagosome Formation and Autophagosome-Lysosome Fusion in N2a Cells Treated with the Prion Protein Fragment 106-126.

Molecular neurobiology

Li Z,Lai M,Li J,Yang D,Zhao M,Wang D,Sun Z,Wen P,Gou F,Dai Y,Ji Y,Zhao D,Qiao J,Yang L

Wed Mar 01 00:00:00 EST 2023

Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.

Chemico-biological interactions

Li J,Bai J,Si X,Jia H,Wu Z

Sat Apr 01 00:00:00 EDT 2023

Autophagic degradation of MVBs in LSECs promotes Aldosterone induced-HSCs activation.

Hepatology international

Chen T,Zhang Y,Zhang Y,Ning Z,Xu Q,Lin Y,Gong J,Li J,Chen Z,Meng Y,Li Y,Li X

Sun Jun 18 00:00:00 EDT 2023

Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.

Cell death and differentiation

Zhang G,Jiang C,Yang Y,Wang Y,Zhou H,Dai S,Liu M,Yang Y,Yang L,Shen Q,Zhang T,Zhang X,Yang Y,Shen Y

Wed Feb 01 00:00:00 EST 2023

Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.

Cell death and differentiation

Zhang G,Jiang C,Yang Y,Wang Y,Zhou H,Dai S,Liu M,Yang Y,Yang L,Shen Q,Zhang T,Zhang X,Yang Y,Shen Y

Wed Feb 01 00:00:00 EST 2023

Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.

Cell death and differentiation

Zhang G,Jiang C,Yang Y,Wang Y,Zhou H,Dai S,Liu M,Yang Y,Yang L,Shen Q,Zhang T,Zhang X,Yang Y,Shen Y

Wed Feb 01 00:00:00 EST 2023

Impaired autophagy flux by lncRNA NEAT1 is critical for inflammation factors production in human periodontal ligament stem cells with nicotine treatment.

Journal of periodontal research

Zhang T,Yang K,Chen Y,Jiang Y,Zhou Z,Liu J,Du Y,Wang L,Han X,Wu X,Wang X

Wed Feb 01 00:00:00 EST 2023

Impaired autophagy flux by lncRNA NEAT1 is critical for inflammation factors production in human periodontal ligament stem cells with nicotine treatment.

Journal of periodontal research

Zhang T,Yang K,Chen Y,Jiang Y,Zhou Z,Liu J,Du Y,Wang L,Han X,Wu X,Wang X

Wed Feb 01 00:00:00 EST 2023

Folate inhibits lipid deposition via the autophagy pathway in chicken hepatocytes.

Poultry science

Du ZQ,Pang YQ,Zhang Y,Wang L,Zhang R,Li H,Yang CX

Wed Feb 01 00:00:00 EST 2023

Zhachong Shisanwei Pill resists ischemic stroke by lysosome pathway based on proteomics and bioinformatics.

Journal of ethnopharmacology

Song Q,Bi L,Jiao J,Shang J,Li Q,Shabuerjiang L,Bai M,Liu X

Mon Jan 30 00:00:00 EST 2023

TFEB coordinates autophagy and pyroptosis as hepatotoxicity responses to ZnO nanoparticles.

The Science of the total environment

Pei X,Liu D,Li J,Li L,Ding X,Zhang W,Li Z,Xu G,Li C,Li D

Mon Mar 20 00:00:00 EDT 2023

Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy.

Virus research

Wang J,Yang G,Zhang L,Zhang J,Wang J,Zou Y,Wang J

Tue Nov 01 00:00:00 EDT 2022

Incomplete autophagy promotes the proliferation of Mycoplasma hyopneumoniae through the JNK and Akt pathways in porcine alveolar macrophages.

Veterinary research

Wen Y,Chen Z,Tian Y,Yang M,Dong Q,Yang Y,Ding H

Thu Aug 04 00:00:00 EDT 2022

YAP1 protects against septic liver injury via ferroptosis resistance.

Cell & bioscience

Wang J,Zhu Q,Li R,Zhang J,Ye X,Li X

Sat Oct 01 00:00:00 EDT 2022

Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.

Molecular cell

Jiang B,Zhang J,Zhao G,Liu M,Hu J,Lin F,Wang J,Zhao W,Ma H,Zhang C,Wu C,Yao L,Liu Q,Chen X,Cao Y,Zheng Y,Zhang C,Han A,Lin D,Li Q

Thu May 19 00:00:00 EDT 2022

Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.

Ecotoxicology and environmental safety

Zhou J,Zhang Y,Zeng L,Wang X,Mu H,Wang M,Pan H,Su P

Thu Sep 01 00:00:00 EDT 2022

Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.

Ecotoxicology and environmental safety

Zhou J,Zhang Y,Zeng L,Wang X,Mu H,Wang M,Pan H,Su P

Thu Sep 01 00:00:00 EDT 2022

Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion.

Cell reports

Tanishita Y,Sekiya H,Inohara N,Tsuchiya K,Mitsuyama M,Núñez G,Hara H

Tue Feb 22 00:00:00 EST 2022

RRM2 Mediates the Anti-Tumor Effect of the Natural Product Pectolinarigenin on Glioblastoma Through Promoting CDK1 Protein Degradation by Increasing Autophagic Flux.

Frontiers in oncology

Jiang H,Zhang D,Aleksandrovich KD,Ye J,Wang L,Chen X,Gao M,Wang X,Yan T,Yang H,Lu E,Liu W,Zhang C,Wu J,Yao P,Sun Z,Rong X,Timofeevich SA,Mahmutovich SS,Zheng Z,Chen X,Zhao S

Sat Jul 16 00:00:00 EDT 2022

RRM2 Mediates the Anti-Tumor Effect of the Natural Product Pectolinarigenin on Glioblastoma Through Promoting CDK1 Protein Degradation by Increasing Autophagic Flux.

Frontiers in oncology

Jiang H,Zhang D,Aleksandrovich KD,Ye J,Wang L,Chen X,Gao M,Wang X,Yan T,Yang H,Lu E,Liu W,Zhang C,Wu J,Yao P,Sun Z,Rong X,Timofeevich SA,Mahmutovich SS,Zheng Z,Chen X,Zhao S

Sat Jul 16 00:00:00 EDT 2022

CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis.

Stem cell research & therapy

Tan J,Xu T,Gou Y,Wang H,Liang Z,Cao Y,Wang H,Yu Y,Jiao N,Zhang Z

Fri Jul 15 00:00:00 EDT 2022

Progranulin Insufficiency Affects Lysosomal Homeostasis in Retinal Pigment Epithelium.

In vivo (Athens, Greece)

Takahashi K,Nakamura S,Shimazawa M,Hara H

Mon Mar 07 00:00:00 EST 2022

Progranulin Insufficiency Affects Lysosomal Homeostasis in Retinal Pigment Epithelium.

In vivo (Athens, Greece)

Takahashi K,Nakamura S,Shimazawa M,Hara H

Mon Mar 07 00:00:00 EST 2022

Pterostilbene Prevents Tunicamycin-Induced Intestinal Barrier Damage by Targeting Endoplasmic Reticulum Stress, Oxidative Stress, Autophagy, and Gut Microbiota.

Journal of agricultural and food chemistry

Chen Y,Zhang H,Li Y,Ji S,Jia P,Wang T

Wed Oct 26 00:00:00 EDT 2022

Prototheca bovis induces autophagy in bovine mammary epithelial cells via the HIF-1α and AMPKα/ULK1 pathway.

Frontiers in immunology

Zhao W,Xu M,Barkema HW,Xie X,Lin Y,Khan S,Kastelic JP,Wang D,Deng Z,Han B

Mon Sep 26 00:00:00 EDT 2022

Ppt1-deficiency dysregulates lysosomal Ca⁺⁺ homeostasis contributing to pathogenesis in a mouse model of CLN1 disease.

Journal of inherited metabolic disease

Mondal A,Appu AP,Sadhukhan T,Bagh MB,Previde RM,Sadhukhan S,Stojilkovic S,Liu A,Mukherjee AB

Sun May 01 00:00:00 EDT 2022

GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis.

Ecotoxicology and environmental safety

Yu S,Li Z,Zhang Q,Wang R,Zhao Z,Ding W,Wang F,Sun C,Tang J,Wang X,Zhang H,Huang R,Wu Q,Jiang J,Zhao X

Fri Apr 01 00:00:00 EDT 2022

The effect of aerobic exercise on the lipophagy of adipose tissue in obese male mice.

Chemistry and physics of lipids

Li R,Li G,Hai Y,Li T,Bian Y,Ma T

Thu Sep 01 00:00:00 EDT 2022

Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.

Redox biology

Liu C,Sun W,Zhu T,Shi S,Zhang J,Wang J,Gao F,Ou Q,Jin C,Li J,Xu JY,Zhang J,Tian H,Xu GT,Lu L

Wed Jun 01 00:00:00 EDT 2022

Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction.

Pharmaceuticals (Basel, Switzerland)

Luo L,Liang Y,Fu Y,Liang Z,Zheng J,Lan J,Shen F,Huang Z

Sat Dec 03 00:00:00 EST 2022

Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction.

Pharmaceuticals (Basel, Switzerland)

Luo L,Liang Y,Fu Y,Liang Z,Zheng J,Lan J,Shen F,Huang Z

Sat Dec 03 00:00:00 EST 2022

SUMO2-mediated SUMOylation of SH3GLB1 promotes ionizing radiation-induced hypertrophic cardiomyopathy through mitophagy activation.

European journal of pharmacology

Gao A,Zou J,Mao Z,Zhou H,Zeng G

Sun Jun 05 00:00:00 EDT 2022

Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress.

Journal of Zhejiang University. Science. B

Lu J,Fu S,Dai J,Hu J,Li S,Ji H,Wang Z,Yu J,Bao J,Xu B,Guo J,Yang H

Wed Jun 15 00:00:00 EDT 2022

PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer.

Cell death & disease

Salvi A,Young AN,Huntsman AC,Pergande MR,Korkmaz MA,Rathnayake RA,Mize BK,Kinghorn AD,Zhang X,Ratia K,Schirle M,Thomas JR,Brittain SM,Shelton C,Aldrich LN,Cologna SM,Fuchs JR,Burdette JE

Mon Jan 10 00:00:00 EST 2022

Liensinine Inhibits Cell Growth and Blocks Autophagic Flux in Nonsmall-Cell Lung Cancer.

Journal of oncology

Chang M,Ding S,Dong X,Shang X,Li Y,Xie L,Song X,Song X

Sat Jul 16 00:00:00 EDT 2022

Pterostilbene attenuates intrauterine growth retardation-induced colon inflammation in piglets by modulating endoplasmic reticulum stress and autophagy.

Journal of animal science and biotechnology

Chen Y,Zhang H,Li Y,Ji S,Jia P,Wang T

Fri Nov 04 00:00:00 EDT 2022

Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.

Stem cell research & therapy

Jin C,Ou Q,Chen J,Wang T,Zhang J,Wang Z,Wang Y,Tian H,Xu JY,Gao F,Wang J,Li J,Lu L,Xu GT

Fri Apr 01 00:00:00 EDT 2022

YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferritinophagy-mediated ferroptosis.

Frontiers in immunology

Zhang J,Zheng Y,Wang Y,Wang J,Sang A,Song X,Li X

Fri Aug 19 00:00:00 EDT 2022

Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells.

Journal of hazardous materials

Zhu Q,Liu Z,Wang Y,Song E,Song Y

Sat Jun 05 00:00:00 EDT 2021

Bhlhe40/Sirt1 Axis-Regulated Mitophagy Is Implicated in All-Trans Retinoic Acid-Induced Spina Bifida Aperta.

Frontiers in cell and developmental biology

Zhao L,Liu D,Ma W,Gu H,Wei X,Luo W,Yuan Z

Sun May 16 00:00:00 EDT 2021

PINK1 Alleviates Cognitive Impairments via Attenuating Pathological Tau Aggregation in a Mouse Model of Tauopathy.

Frontiers in cell and developmental biology

Jiang XJ,Wu YQ,Ma R,Chang YM,Li LL,Zhu JH,Liu GP,Li G

Sat Jan 22 00:00:00 EST 2022

Gastrodin ameliorates learning and memory impairment in rats with vascular dementia by promoting autophagy flux via inhibition of the Ca²⁺/CaMKII signal pathway.

Aging

Chen TT,Zhou X,Xu YN,Li Y,Wu XY,Xiang Q,Fu LY,Hu XX,Tao L,Shen XC

Wed Mar 10 00:00:00 EST 2021

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI.

Cell death & disease

Chen C,Wang D,Yu Y,Zhao T,Min N,Wu Y,Kang L,Zhao Y,Du L,Zhang M,Gong J,Zhang Z,Zhang Y,Mi X,Yue S,Tan X

Mon Jan 11 00:00:00 EST 2021

Atmospheric particulate matter impedes autophagic flux by impairing lysosomal milieu and integrity in human umbilical vein endothelial cells (HUVECs).

The Science of the total environment

Wang Y,Liu N,Huang X,Hu W,Ma Y,Liang Y,Xie W,Tang M

Sat Mar 20 00:00:00 EDT 2021

Atmospheric particulate matter impedes autophagic flux by impairing lysosomal milieu and integrity in human umbilical vein endothelial cells (HUVECs).

The Science of the total environment

Wang Y,Liu N,Huang X,Hu W,Ma Y,Liang Y,Xie W,Tang M

Sat Mar 20 00:00:00 EDT 2021

Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR-p70S6K pathway.

FEBS open bio

Zuo SQ,Li C,Liu YL,Tan YH,Wan X,Xu T,Li Q,Wang L,Wu YL,Deng FM,Tang B

Fri Oct 01 00:00:00 EDT 2021

SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy Impairment.

Frontiers in microbiology

Shang C,Liu Z,Zhu Y,Lu J,Ge C,Zhang C,Li N,Jin N,Li Y,Tian M,Li X

Tue Jan 25 00:00:00 EST 2022

Classical swine fever virus infection suppresses claudin-1 expression to facilitate its replication in PK-15 cells.

Microbial pathogenesis

Wang X,Yang Y,Yang X,Liu X,Wang X,Gao L,Yang C,Lan R,Bi J,Zhao Q,Yang G,Wang J,Lin Y,Liu J,Yin G

Sun Aug 01 00:00:00 EDT 2021

Classical swine fever virus infection suppresses claudin-1 expression to facilitate its replication in PK-15 cells.

Microbial pathogenesis

Wang X,Yang Y,Yang X,Liu X,Wang X,Gao L,Yang C,Lan R,Bi J,Zhao Q,Yang G,Wang J,Lin Y,Liu J,Yin G

Sun Aug 01 00:00:00 EDT 2021

Glucose-induced decrease of cystathionine β-synthase mediates renal injuries.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Yu Y,Xiao L,Ren Z,Zhu G,Wang W,Jia Y,Peng A,Wang X

Sat May 01 00:00:00 EDT 2021

Fatty acid binding protein 3 deficiency limits atherosclerosis development via macrophage foam cell formation inhibition.

Experimental cell research

Tan L,Lu J,Liu L,Li L

Fri Oct 01 00:00:00 EDT 2021

Fatty acid binding protein 3 deficiency limits atherosclerosis development via macrophage foam cell formation inhibition.

Experimental cell research

Tan L,Lu J,Liu L,Li L

Fri Oct 01 00:00:00 EDT 2021

The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.

Frontiers in pharmacology

Yu Y,Liu X,Zhao Z,Xu Z,Qiao Y,Zhou Y,Qiao H,Zhong J,Dai J,Suo G

Fri Dec 24 00:00:00 EST 2021

Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1.

Signal transduction and targeted therapy

Xiao W,Yeerken D,Li J,Li Z,Jiang L,Li D,Fu M,Ma L,Song Y,Zhang W,Zhan Q

Fri Apr 16 00:00:00 EDT 2021

Mutation analysis of MFSD8 in an amyotrophic lateral sclerosis cohort from mainland China.

The European journal of neuroscience

Huang L,Liu Z,Yuan Y,Shen L,Jiang H,Tang B,Wang J,Lei L

Mon Feb 01 00:00:00 EST 2021

Mutation analysis of MFSD8 in an amyotrophic lateral sclerosis cohort from mainland China.

The European journal of neuroscience

Huang L,Liu Z,Yuan Y,Shen L,Jiang H,Tang B,Wang J,Lei L

Mon Feb 01 00:00:00 EST 2021

Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.

International journal of molecular sciences

Wang S,Xu X,Che D,Fan R,Gao M,Cao Y,Ge C,Feng Y,Li J,Xie S,Wang C,Dai F,Gao L,Wang Y

Tue Oct 12 00:00:00 EDT 2021

Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.

Cell death and differentiation

Lu J,Xu S,Huo Y,Sun D,Hu Y,Wang J,Zhang X,Wang P,Li Z,Liang M,Wu Z,Liu P

Fri Oct 01 00:00:00 EDT 2021

Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH.

Journal of neuroinflammation

Zeng H,Chen H,Li M,Zhuang J,Peng Y,Zhou H,Xu C,Yu Q,Fu X,Cao S,Cai J,Yan F,Chen G

Thu Sep 16 00:00:00 EDT 2021

Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease.

Clinical and translational science

Kang J,Kim JW,Heo H,Lee J,Park KY,Yoon JH,Chang J

Mon Mar 01 00:00:00 EST 2021

Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy.

Cell proliferation

Chen L,Mei G,Jiang C,Cheng X,Li D,Zhao Y,Chen H,Wan C,Yao P,Gao C,Tang Y

Tue Jun 01 00:00:00 EDT 2021

Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy.

Cell proliferation

Chen L,Mei G,Jiang C,Cheng X,Li D,Zhao Y,Chen H,Wan C,Yao P,Gao C,Tang Y

Tue Jun 01 00:00:00 EDT 2021

Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.

Frontiers in cardiovascular medicine

Yu YW,Que JQ,Liu S,Huang KY,Qian L,Weng YB,Rong FN,Wang L,Zhou YY,Xue YJ,Ji KT

Fri Jan 28 00:00:00 EST 2022

CLEC5A knockdown protects against cardiac dysfunction after myocardial infarction by suppressing macrophage polarization, NLRP3 inflammasome activation, and pyroptosis.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Wang X,Hu Y,Wang Y,Shen D,Tao G

Fri Oct 01 00:00:00 EDT 2021

Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.

Nature

Liu X,Bao X,Hu M,Chang H,Jiao M,Cheng J,Xie L,Huang Q,Li F,Li CY

Tue Dec 01 00:00:00 EST 2020

Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway.

Journal of experimental & clinical cancer research : CR

Yang Y,Wang Q,Song D,Zen R,Zhang L,Wang Y,Yang H,Zhang D,Jia J,Zhang J,Wang J

Tue Sep 22 00:00:00 EDT 2020

3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.

Environmental pollution (Barking, Essex : 1987)

Liu N,Yang Y,Chen J,Jia H,Zhang Y,Jiang D,Wu G,Wu Z

Thu Oct 01 00:00:00 EDT 2020

3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.

Environmental pollution (Barking, Essex : 1987)

Liu N,Yang Y,Chen J,Jia H,Zhang Y,Jiang D,Wu G,Wu Z

Thu Oct 01 00:00:00 EDT 2020

Butyrate-mediated autophagy inhibition limits cytosolic Salmonella Infantis replication in the colon of pigs treated with a mixture of Lactobacillus and Bacillus.

Veterinary research

Chu B,Zhu Y,Su J,Xia B,Zou Y,Nie J,Zhang W,Wang J

Wed Aug 05 00:00:00 EDT 2020

TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation.

The Journal of clinical investigation

Zhang H,Tian X,Lu X,Xu D,Guo Y,Dong Z,Li Y,Ma Y,Chen C,Yang Y,Yang M,Yang Y,Liu F,Zhou R,He M,Xiao F,Wang X

Tue Sep 03 00:00:00 EDT 2019

Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance.

Cell death & disease

Liu Y,Tang J,Liu D,Zhang L,He Y,Li J,Gao L,Tang D,Jin X,Kong D

Sun Apr 01 00:00:00 EDT 2018

Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance.

Cell death & disease

Liu Y,Tang J,Liu D,Zhang L,He Y,Li J,Gao L,Tang D,Jin X,Kong D

Sun Apr 01 00:00:00 EDT 2018

Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance.

Cell death & disease

Liu Y,Tang J,Liu D,Zhang L,He Y,Li J,Gao L,Tang D,Jin X,Kong D

Sun Apr 01 00:00:00 EDT 2018

Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance.

Cell death & disease

Liu Y,Tang J,Liu D,Zhang L,He Y,Li J,Gao L,Tang D,Jin X,Kong D

Sun Apr 01 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: CD107 antigen-like family member B; CD107b; Igp96; LAMP-2; LAMP-2 Isoform 2A; LAMP-2 Variant A; LGP-96; LGP-B; lysosomal membrane glycoprotein 2; Lysosomal membrane glycoprotein type B; lysosomal-associated membrane protein 2; Lysosome-associated membrane glycoprotein 2; RP23-193O17.2

View more View less

Gene Aliases: CD107b; Lamp II; LAMP-2; Lamp-2a; Lamp-2b; Lamp-2c; LAMP2; LAMPB; LGP-B; LGP110; Mac3

View more View less

UniProt ID: (Human) P13473, (Mouse) P17047

View more View less

Entrez Gene ID: (Pig) 100154598, (Human) 3920, (Mouse) 16784

View more View less

Function(s)

protein binding enzyme binding protein domain specific binding membrane trafficking regulatory protein

Process(es)

platelet degranulation protein import regulation of protein stability muscle cell cellular homeostasis protein stabilization chaperone-mediated autophagy

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

LAMP2 Monoclonal Antibody (2D3B9)

LAMP2 Antibody (66301-1-IG) in ICC/IF

Product Details

66301-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!