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MA5-17186 targets TGFb1 in FACS, IHC, indirect ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17186 immunogen is purified recombinant fragment of human TGFb1 (amino acids: 62-195) expressed in E. Coli.
MA5-17186 detects TGFb1 which has a predicted molecular weight of approximately 44.3kDa.
TGF beta-1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-b1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF-beta, an aminoterminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: latency-associated peptide; prepro-transforming growth factor beta-1; TGF-beta-1; Transforming growth factor beta-1 proprotein
Gene Aliases: CED; DPD1; LAP; TGFB; TGFB1; TGFbeta
UniProt ID: (Human) P01137
Entrez Gene ID: (Human) 7040
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