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Product Details
MA1-40029
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
M330-19
Immunogen
Murine natural and recombinant LBP.
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2138329
Product Specific Information
Endotoxin level < 24 EU/mg.
The MA1-40029 immunogen is mouse natural and recombinant LBP.
MA1-40029 detects LBP from mouse samples.
This antibody reacts highly specific with mouse natural and recombinant LBP. The antibody is a type I antibody blocking the LPS binding to LBP.
MA1-40029 has been successfully used in FACS and ELISA applications.
Target Information
The LBP protein is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LBP; Lipopolysaccharide-binding protein
Gene Aliases: Bpifd2; Lbp; Ly88
UniProt ID: (Mouse) Q61805
Entrez Gene ID: (Mouse) 16803
leukocyte chemotaxis involved in inflammatory response
macrophage activation involved in immune response
immune system process
transport
lipid transport
acute-phase response
lipopolysaccharide transport
lipopolysaccharide-mediated signaling pathway
detection of molecule of bacterial origin
response to lipopolysaccharide
negative regulation of tumor necrosis factor production
positive regulation of chemokine production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
positive regulation of macrophage activation
negative regulation of growth of symbiont in host
innate immune response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of phagocytosis, engulfment
positive regulation of respiratory burst involved in inflammatory response
cellular response to lipopolysaccharide
cellular response to lipoteichoic acid
positive regulation of neutrophil chemotaxis
regulation of membrane permeability
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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