Product References
Intra-articular injection of rapamycin microparticles prevent senescence and effectively treat osteoarthritis.
Bioengineering & translational medicine
Dhanabalan KM,Dravid AA,Agarwal S,Sharath RK,Padmanabhan AK,Agarwal R
PA1-16930 was used in ChIP Assay, ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Proximity Ligation Assay to demonstrate s the feasibility of using RMPs as a potential clinically translatable therapy to prevent the progression of post-traumatic OA.
Sun Jan 01 00:00:00 EST 2023
Intra-articular injection of rapamycin microparticles prevent senescence and effectively treat osteoarthritis.
Bioengineering & translational medicine
Dhanabalan KM,Dravid AA,Agarwal S,Sharath RK,Padmanabhan AK,Agarwal R
PA1-16930 was used in ChIP Assay, ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Proximity Ligation Assay to demonstrate s the feasibility of using RMPs as a potential clinically translatable therapy to prevent the progression of post-traumatic OA.
Sun Jan 01 00:00:00 EST 2023
Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer's Disease Pathogenesis.
Cells
Barazzuol L,Cieri D,Facchinello N,Calì T,Washbourne P,Argenton F,Pizzo P
PA1-16930 was used in ChIP Assay, ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Proximity Ligation Assay, Western Blot to investigate Alzheimer's Disease pathogenesis regulation by presenilin 2.
Thu Jan 19 00:00:00 EST 2023
Protein Arginylation Is Regulated during SARS-CoV-2 Infection.
Viruses
Macedo-da-Silva J,Rosa-Fernandes L,Gomes VM,Santiago VF,Santos DM,Molnar CMS,Barboza BR,de Souza EE,Marques RF,Boscardin SB,Durigon EL,Marinho CRF,Wrenger C,Marie SKN,Palmisano G
PA1-16930 was used in Western Blotting to demonstrate that ATE1 is increased during SARS-CoV-2 infection and its inhibition has potential therapeutic value.
Thu Jan 19 00:00:00 EST 2023
Protein Arginylation Is Regulated during SARS-CoV-2 Infection.
Viruses
Macedo-da-Silva J,Rosa-Fernandes L,Gomes VM,Santiago VF,Santos DM,Molnar CMS,Barboza BR,de Souza EE,Marques RF,Boscardin SB,Durigon EL,Marinho CRF,Wrenger C,Marie SKN,Palmisano G
PA1-16930 was used in Western Blotting to demonstrate that ATE1 is increased during SARS-CoV-2 infection and its inhibition has potential therapeutic value.
Thu Jan 19 00:00:00 EST 2023
Protein Arginylation Is Regulated during SARS-CoV-2 Infection.
Viruses
Macedo-da-Silva J,Rosa-Fernandes L,Gomes VM,Santiago VF,Santos DM,Molnar CMS,Barboza BR,de Souza EE,Marques RF,Boscardin SB,Durigon EL,Marinho CRF,Wrenger C,Marie SKN,Palmisano G
PA1-16930 was used in Western Blotting to demonstrate that ATE1 is increased during SARS-CoV-2 infection and its inhibition has potential therapeutic value.
Thu Jan 19 00:00:00 EST 2023
STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death.
Cancers
Remy J,Linder B,Weirauch U,Day BW,Stringer BW,Herold-Mende C,Aigner A,Krohn K,Kögel D
PA1-16930 was used in Western Blotting to support the concept of exploiting the pro-death functions of autophagy and LMP for GBM therapy and to further determine whether STAT3 can be employed as a treatment predictor for highly apoptosis-resistant, but autophagy-proficient cancers.
Tue Jan 11 00:00:00 EST 2022
Degradation of lipid droplets by chimeric autophagy-tethering compounds.
Cell research
Fu Y,Chen N,Wang Z,Luo S,Ding Y,Lu B
PA1-16930 was used in Western Blot to demonstrate the capability of degrading LDs by ATTECs.
Wed Sep 01 00:00:00 EDT 2021
Degradation of lipid droplets by chimeric autophagy-tethering compounds.
Cell research
Fu Y,Chen N,Wang Z,Luo S,Ding Y,Lu B
PA1-16930 was used in Western Blot to demonstrate the capability of degrading LDs by ATTECs.
Wed Sep 01 00:00:00 EDT 2021
ATF4 links ER stress with reticulophagy in glioblastoma cells.
Autophagy
Zielke S,Kardo S,Zein L,Mari M,Covarrubias-Pinto A,Kinzler MN,Meyer N,Stolz A,Fulda S,Reggiori F,Kögel D,van Wijk S
PA1-16930 was used in Immunoprecipitation to explore the autophagy-inducing mechanisms that underlie loperamide in glioblastoma cells.
Wed Sep 01 00:00:00 EDT 2021
Reduced Expression of Autophagy Markers and Expansion of Myeloid-Derived Suppressor Cells Correlate With Poor T Cell Response in Severe COVID-19 Patients.
Frontiers in immunology
Tomić S,Đokić J,Stevanović D,Ilić N,Gruden-Movsesijan A,Dinić M,Radojević D,Bekić M,Mitrović N,Tomašević R,Mikić D,Stojanović D,Čolić M
PA1-16930 was used in Western Blotting to analyse ~140 parameters of cellular and humoral immune response in peripheral blood of 41 COVID-19 patients and 16 age/gender-matched healthy donors by flow-cytometry, quantitative PCR, western blot and ELISA, followed by integrated correlation analyses with ~30 common clinical and laboratory parameters.
Wed Apr 07 00:00:00 EDT 2021
Reduced Expression of Autophagy Markers and Expansion of Myeloid-Derived Suppressor Cells Correlate With Poor T Cell Response in Severe COVID-19 Patients.
Frontiers in immunology
Tomić S,Đokić J,Stevanović D,Ilić N,Gruden-Movsesijan A,Dinić M,Radojević D,Bekić M,Mitrović N,Tomašević R,Mikić D,Stojanović D,Čolić M
PA1-16930 was used in Western Blotting to analyse ~140 parameters of cellular and humoral immune response in peripheral blood of 41 COVID-19 patients and 16 age/gender-matched healthy donors by flow-cytometry, quantitative PCR, western blot and ELISA, followed by integrated correlation analyses with ~30 common clinical and laboratory parameters.
Wed Apr 07 00:00:00 EDT 2021
Pathomorphological sequence of nephron loss in diabetic nephropathy.
American journal of physiology. Renal physiology
Löwen J,Gröne EF,Groß-Weißmann ML,Bestvater F,Gröne HJ,Kriz W
PA1-16930 was used in Immunohistochemistry to describe the advanced stages of DN terminating in glomerular obsolescence and tubulointerstitial fibrosis based on a total of 918 biopsies.
Mon Nov 01 00:00:00 EDT 2021
The Polyphenol Pterostilbene Ameliorates the Myopathic Phenotype of Collagen VI Deficient Mice via Autophagy Induction.
Frontiers in cell and developmental biology
Metti S,Gambarotto L,Chrisam M,Baraldo M,Braghetta P,Blaauw B,Bonaldo P
PA1-16930 was used in Western Blotting to show that pterostilbene (Pt)-a non-toxic polyphenol, chemically similar to resveratrol but with a higher bioavailability and metabolic stability-strongly promotes in vivo autophagic flux in the skeletal muscle of both wild-type and COL6 null mice.
Mon Feb 15 00:00:00 EST 2021
The Polyphenol Pterostilbene Ameliorates the Myopathic Phenotype of Collagen VI Deficient Mice via Autophagy Induction.
Frontiers in cell and developmental biology
Metti S,Gambarotto L,Chrisam M,Baraldo M,Braghetta P,Blaauw B,Bonaldo P
PA1-16930 was used in Western Blotting to show that pterostilbene (Pt)-a non-toxic polyphenol, chemically similar to resveratrol but with a higher bioavailability and metabolic stability-strongly promotes in vivo autophagic flux in the skeletal muscle of both wild-type and COL6 null mice.
Mon Feb 15 00:00:00 EST 2021
The Polyphenol Pterostilbene Ameliorates the Myopathic Phenotype of Collagen VI Deficient Mice via Autophagy Induction.
Frontiers in cell and developmental biology
Metti S,Gambarotto L,Chrisam M,Baraldo M,Braghetta P,Blaauw B,Bonaldo P
PA1-16930 was used in Western Blotting to show that pterostilbene (Pt)-a non-toxic polyphenol, chemically similar to resveratrol but with a higher bioavailability and metabolic stability-strongly promotes in vivo autophagic flux in the skeletal muscle of both wild-type and COL6 null mice.
Mon Feb 15 00:00:00 EST 2021
Clinical and preclinical therapeutic outcome metrics for USH2A-related disease.
Human molecular genetics
Toms M,Dubis AM,de Vrieze E,Tracey-White D,Mitsios A,Hayes M,Broekman S,Baxendale S,Utoomprurkporn N,Bamiou D,Bitner-Glindzicz M,Webster AR,Van Wijk E,Moosajee M
PA1-16930 was used in Western Blot, Immunohistochemistry to identify metrics for the evaluation of future clinical trials and rapid preclinical screening studies.
Tue Jul 21 00:00:00 EDT 2020
Clinical and preclinical therapeutic outcome metrics for USH2A-related disease.
Human molecular genetics
Toms M,Dubis AM,de Vrieze E,Tracey-White D,Mitsios A,Hayes M,Broekman S,Baxendale S,Utoomprurkporn N,Bamiou D,Bitner-Glindzicz M,Webster AR,Van Wijk E,Moosajee M
PA1-16930 was used in Western Blot, Immunohistochemistry to identify metrics for the evaluation of future clinical trials and rapid preclinical screening studies.
Tue Jul 21 00:00:00 EDT 2020
Clinical and preclinical therapeutic outcome metrics for USH2A-related disease.
Human molecular genetics
Toms M,Dubis AM,de Vrieze E,Tracey-White D,Mitsios A,Hayes M,Broekman S,Baxendale S,Utoomprurkporn N,Bamiou D,Bitner-Glindzicz M,Webster AR,Van Wijk E,Moosajee M
PA1-16930 was used in Western Blot, Immunohistochemistry to identify metrics for the evaluation of future clinical trials and rapid preclinical screening studies.
Tue Jul 21 00:00:00 EDT 2020
Clinical and preclinical therapeutic outcome metrics for USH2A-related disease.
Human molecular genetics
Toms M,Dubis AM,de Vrieze E,Tracey-White D,Mitsios A,Hayes M,Broekman S,Baxendale S,Utoomprurkporn N,Bamiou D,Bitner-Glindzicz M,Webster AR,Van Wijk E,Moosajee M
PA1-16930 was used in Western Blot, Immunohistochemistry to identify metrics for the evaluation of future clinical trials and rapid preclinical screening studies.
Tue Jul 21 00:00:00 EDT 2020
A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins.
Cells
Catarino S,Ribeiro-Rodrigues TM,Sá Ferreira R,Ramalho J,Abert C,Martens S,Girão H
PA1-16930 was used in Western Blotting to describe an alternative mechanism whereby Cxs interact with LC3/GABARAP proteins, envisioning a new model for the autophagy degradation of connexins.
Tue Apr 07 00:00:00 EDT 2020
A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins.
Cells
Catarino S,Ribeiro-Rodrigues TM,Sá Ferreira R,Ramalho J,Abert C,Martens S,Girão H
PA1-16930 was used in Western Blotting to describe an alternative mechanism whereby Cxs interact with LC3/GABARAP proteins, envisioning a new model for the autophagy degradation of connexins.
Tue Apr 07 00:00:00 EDT 2020
Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer.
Cell death & disease
Ma J,Ramachandran M,Jin C,Quijano-Rubio C,Martikainen M,Yu D,Essand M
Published figure using LC3B polyclonal antibody (Product # PA1-16930) in Western Blot
Wed Jan 22 00:00:00 EST 2020
Palmitoylation controls trafficking of the intracellular Ca2+ channel MCOLN3/TRPML3 to regulate autophagy.
Autophagy
Kim SW,Kim DH,Park KS,Kim MK,Park YM,Muallem S,So I,Kim HJ
PA1-16930 was used in Western Blotting to show that trafficking and channel function of MCOLN3/TRPML3 are regulated in the context of autophagy.
Fri Feb 01 00:00:00 EST 2019
The epg5 knockout zebrafish line: a model to study Vici syndrome.
Autophagy
Meneghetti G,Skobo T,Chrisam M,Facchinello N,Fontana CM,Bellesso S,Sabatelli P,Raggi F,Cecconi F,Bonaldo P,Dalla Valle L
PA1-16930 was used in Western Blotting to show that the zebrafish epg5 mutant as a valuable model for EPG5-related disorders, provides a new tool for dissecting the contribution of EPG5 on the onset and progression of Vici syndrome as well as for the screening of autophagy-stimulating drugs.
Thu Aug 01 00:00:00 EDT 2019
Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds.
Nature
Li Z,Wang C,Wang Z,Zhu C,Li J,Sha T,Ma L,Gao C,Yang Y,Sun Y,Wang J,Sun X,Lu C,Difiglia M,Mei Y,Ding C,Luo S,Dang Y,Ding Y,Fei Y,Lu B
PA1-16930 was used in Western Blotting to demonstrate the concept of lowering levels of disease-causing proteins using autophagosome-tethering compounds.
Fri Nov 01 00:00:00 EDT 2019
Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer.
Cell reports
Bacci M,Lorito N,Ippolito L,Ramazzotti M,Luti S,Romagnoli S,Parri M,Bianchini F,Cappellesso F,Virga F,Gao Q,Simões BM,Marangoni E,Martin LA,Comito G,Ferracin M,Giannoni E,Mazzone M,Chiarugi P,Morandi A
PA1-16930 was used in Western Blotting to provide insight into the metabolic deregulation of endocrine therapy resistant (ETR) cells, and discover molecules that may prove useful in identifying a signature for breast cancer patients with an increased risk of ETR.
Tue Jul 02 00:00:00 EDT 2019
Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR.
Cell death & disease
Lian WS,Ko JY,Chen YS,Ke HC,Wu SL,Kuo CW,Wang FS
PA1-16930 was used in Western Blotting to show that HSP60 is essential to maintain osteoblast autophagy, which facilitates mineralized matrix production.
Mon Sep 17 00:00:00 EDT 2018
Deep RNA profiling identified CLOCK and molecular clock genes as pathophysiological signatures in collagen VI myopathy.
Journal of cell science
Scotton C,Bovolenta M,Schwartz E,Falzarano MS,Martoni E,Passarelli C,Armaroli A,Osman H,Rodolico C,Messina S,Pegoraro E,D'Amico A,Bertini E,Gualandi F,Neri M,Selvatici R,Boffi P,Maioli MA,Lochmüller H,Straub V,Bushby K,Castrignanò T,Pesole G,Sabatelli P,Merlini L,Braghetta P,Bonaldo P,Bernardi P,Foley R,Cirak S,Zaharieva I,Muntoni F,Capitanio D,Gelfi C,Kotelnikova E,Yuryev A,Lebowitz M,Zhang X,Hodge BA,Esser KA,Ferlini A
PA1-16930 was used in western blot to utilize deep RNA profiling to identify molecular clock genes and CLOCK as pathophysiological signatures found in collagen VI myopathy
Fri Apr 15 00:00:00 EDT 2016
Short communication: Effect of heat stress on markers of autophagy in the mammary gland during the dry period.
Journal of dairy science
Wohlgemuth SE,Ramirez-Lee Y,Tao S,Monteiro APA,Ahmed BM,Dahl GE
PA1-16930 was used in western blot to study the mammary gland during the dry period and the effect of heat stress on markers of autophagy
Wed Jun 01 00:00:00 EDT 2016
Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice.
Autophagy
Chrisam M,Pirozzi M,Castagnaro S,Blaauw B,Polishchuck R,Cecconi F,Grumati P,Bonaldo P
PA1-16930 was used in western blot to assess the effects of an autophagy inducer on col6a1 knock out mice
Mon Oct 31 00:00:00 EDT 2016
Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice.
Autophagy
Chrisam M,Pirozzi M,Castagnaro S,Blaauw B,Polishchuck R,Cecconi F,Grumati P,Bonaldo P
PA1-16930 was used in western blot to assess the effects of an autophagy inducer on col6a1 knock out mice
Mon Oct 31 00:00:00 EDT 2016
Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide.
Cell cycle (Georgetown, Tex.)
Huna A,Salmina K,Erenpreisa J,Vazquez-Martin A,Krigerts J,Inashkina I,Gerashchenko BI,Townsend PA,Cragg MS,Jackson TR
Published figure using LC3B polyclonal antibody (Product # PA1-16930) in Western Blot
Wed Aug 03 00:00:00 EDT 2016
Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling.
Journal of virology
Xia M,Gonzalez P,Li C,Meng G,Jiang A,Wang H,Gao Q,Debatin KM,Beltinger C,Wei J
PA1-16930 was used in western blot to study the mechanism for the oncolytic measles virus replication
Thu May 01 00:00:00 EDT 2014
Mitophagy promotes replication of oncolytic Newcastle disease virus by blocking intrinsic apoptosis in lung cancer cells.
Oncotarget
Meng G,Xia M,Wang D,Chen A,Wang Y,Wang H,Yu D,Wei J
PA1-16930 was used in western blot to study the promotion of mitophagy by oncolytic Newcastle disease virus on and its effect on viral replication
Fri Aug 15 00:00:00 EDT 2014
Vitamin E as a novel enhancer of macroautophagy in rat hepatocytes and H4-II-E cells.
Biochemical and biophysical research communications
Karim MR,Fujimura S,Kadowaki M
PA1-16930 was used in western blot to investigate the effect of vitamin E on macroautophagy in liver cells
Fri Apr 16 00:00:00 EDT 2010
