Product References
The citrus flavonoid "Nobiletin" impedes STZ-induced Alzheimer's disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism.
Inflammopharmacology
El-Maraghy SA,Reda A,Essam RM,Kortam MA
Published figure using LC3B polyclonal antibody (Product # PA1-46286) in Western Blot
Sun Oct 01 00:00:00 EDT 2023
N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.
Nature communications
Varland S,Silva RD,Kjosås I,Faustino A,Bogaert A,Billmann M,Boukhatmi H,Kellen B,Costanzo M,Drazic A,Osberg C,Chan K,Zhang X,Tong AHY,Andreazza S,Lee JJ,Nedyalkova L,Ušaj M,Whitworth AJ,Andrews BJ,Moffat J,Myers CL,Gevaert K,Boone C,Martinho RG,Arnesen T
PA1-46286 was used in Western Blot to developmental muscle defects.
Fri Oct 27 00:00:00 EDT 2023
MAGED2 Depletion Promotes Stress-Induced Autophagy by Impairing the cAMP/PKA Pathway.
International journal of molecular sciences
Nasrah S,Radi A,Daberkow JK,Hummler H,Weber S,Seaayfan E,Kömhoff M
PA1-46286 was used in Immunocytochemistry and Immunohistochemistry to show that two members of the melanoma-associated antigens MAGE-family inhibit autophagy.
Wed Aug 30 00:00:00 EDT 2023
MAGED2 Depletion Promotes Stress-Induced Autophagy by Impairing the cAMP/PKA Pathway.
International journal of molecular sciences
Nasrah S,Radi A,Daberkow JK,Hummler H,Weber S,Seaayfan E,Kömhoff M
PA1-46286 was used in Immunocytochemistry and Immunohistochemistry to show that two members of the melanoma-associated antigens MAGE-family inhibit autophagy.
Wed Aug 30 00:00:00 EDT 2023
Advances on the early cellular events occurring upon exposure of human macrophages to aluminum oxyhydroxide adjuvant.
Scientific reports
Masson JD,Badran G,Domdom MA,Gherardi RK,Mograbi B,Authier FJ,Crépeaux G
PA1-46286 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to investigate the early in vitro response of primary human PBMCs obtained from healthy individuals to aluminum oxyhydroxide (the most commonly used adjuvant) and a whole vaccine, in terms of internalization, conventional and non-conventional autophagy pathways, inflammation, ROS production, and mitochondrial metabolism.
Thu Feb 23 00:00:00 EST 2023
TRPM2 regulates autophagy to participate in hepatitis B virus replication.
Journal of viral hepatitis
Chen L,Zhu L,Lu X,Ming X,Yang B
PA1-46286 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to indicate that Hepatitis B virus (HVB) infection promotes TRPM2 expression, and TRPM2 interacts with p47 phox to induce autophagy and facilitate HVB replication.
Mon Aug 01 00:00:00 EDT 2022
Abnormal lipid metabolism in epidermal Langerhans cells mediates psoriasis-like dermatitis.
JCI insight
Zhang X,Li X,Wang Y,Chen Y,Hu Y,Guo C,Yu Z,Xu P,Ding Y,Mi QS,Wu J,Gu J,Shi Y
PA1-46286 was used in Flow cytometry/Cell sorting to suggest that dysregulated lipid metabolism influences LC immunofunction, which contributes to the development of psoriasis, and therapeutic manipulation of this metabolic process might provide an effective measurement for psoriasis.
Fri Jul 08 00:00:00 EDT 2022
The Improvement of Porcine In Vitro Embryo Development through Regulating Autophagy by miRNA-143 Inhibition.
Animals : an open access journal from MDPI
Ridlo MR,Kim EH,Kim EP,Kim GA
PA1-46286 was used in Immunohistochemistry-immunofluorescence to examine the effect of miR-143 (via mimics and inhibitors) on embryonic development threatened by microinjection after parthenogenetic activation.
Sun Oct 02 00:00:00 EDT 2022
Dihydroxyacetone suppresses mTOR nutrient signaling and induces mitochondrial stress in liver cells.
PloS one
Hernandez A,Sonavane M,Smith KR,Seiger J,Migaud ME,Gassman NR
PA1-46286 was used in Western Blotting to examine cytotoxicity and investigated the cell death mechanism induced by DHA exposure in HepG3 cells.
Thu Dec 15 00:00:00 EST 2022
ATF4 links ER stress with reticulophagy in glioblastoma cells.
Autophagy
Zielke S,Kardo S,Zein L,Mari M,Covarrubias-Pinto A,Kinzler MN,Meyer N,Stolz A,Fulda S,Reggiori F,Kögel D,van Wijk S
PA1-46286 was used in Immunohistochemistry-immunofluorescence to explore the autophagy-inducing mechanisms that underlie loperamide in glioblastoma cells.
Wed Sep 01 00:00:00 EDT 2021
The Biochemical Pathways of Nicotinamide-Derived Pyridones.
International journal of molecular sciences
Hayat F,Sonavane M,Makarov MV,Trammell SAJ,McPherson P,Gassman NR,Migaud ME
PA1-46286 was used in Western Blotting to characterize the catabolites of vitamin B3, justify their nomenclature, and differentiate between the biochemical pathways that lead to their generation.
Sun Jan 24 00:00:00 EST 2021
The Biochemical Pathways of Nicotinamide-Derived Pyridones.
International journal of molecular sciences
Hayat F,Sonavane M,Makarov MV,Trammell SAJ,McPherson P,Gassman NR,Migaud ME
PA1-46286 was used in Western Blotting to characterize the catabolites of vitamin B3, justify their nomenclature, and differentiate between the biochemical pathways that lead to their generation.
Sun Jan 24 00:00:00 EST 2021
Inhibition of the C-X-C Motif Chemokine 12 (CXCL12) and Its Receptor CXCR4 Reduces Utero-Placental Expression of the VEGF System and Increases Utero-Placental Autophagy.
Frontiers in veterinary science
Ashley RL,Runyan CL,Maestas MM,Trigo E,Silver G
PA1-46286 was used in Western Blotting to investigate the role of CXCL12-CXCR4 signaling in uteroplacental vascular remodeling during early placental development in sheep, revealing its importance in placental homeostasis and development through its impact on angiogenic factors and cell viability.
Tue Sep 07 00:00:00 EDT 2021
Inhibition of the C-X-C Motif Chemokine 12 (CXCL12) and Its Receptor CXCR4 Reduces Utero-Placental Expression of the VEGF System and Increases Utero-Placental Autophagy.
Frontiers in veterinary science
Ashley RL,Runyan CL,Maestas MM,Trigo E,Silver G
PA1-46286 was used in Western Blotting to investigate the role of CXCL12-CXCR4 signaling in uteroplacental vascular remodeling during early placental development in sheep, revealing its importance in placental homeostasis and development through its impact on angiogenic factors and cell viability.
Tue Sep 07 00:00:00 EDT 2021
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity.
Nature communications
Thery F,Martina L,Asselman C,Zhang Y,Vessely M,Repo H,Sedeyn K,Moschonas GD,Bredow C,Teo QW,Zhang J,Leandro K,Eggermont D,De Sutter D,Boucher K,Hochepied T,Festjens N,Callewaert N,Saelens X,Dermaut B,Knobeloch KP,Beling A,Sanyal S,Radoshevich L,Eyckerman S,Impens F
PA1-46286 was used in Western Blot to identify ISG15-binding proteins and discover Ring Finger Protein 213 (RNF213) as an ISG15 interactor and cellular sensor of ISGylated proteins.
Fri Oct 01 00:00:00 EDT 2021
Cleaved PINK1 induces neuronal plasticity through PKA-mediated BDNF functional regulation.
Journal of neuroscience research
Soman SK,Tingle D,Dagda RY,Torres M,Dagda M,Dagda RK
PA1-46286 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to study the molecular mechanisms by which cPINK1 promotes neurite outgrowth.
Wed Sep 01 00:00:00 EDT 2021
Long Term Pharmacological Perturbation of Autophagy in Mice: Are HCQ Injections a Relevant Choice?
Biomedicines
Masson JD,Blanchet B,Periou B,Authier FJ,Mograbi B,Gherardi RK,Crépeaux G
PA1-46286 was used in Western Blotting to develop a murine model of long-term systemic autophagy dysfunction, by the way of repeated injections of hydroxychloroquine (HCQ) in both juvenile and adult animals, while ensuring a limited impact on development, behaviour and motricity.
Sun Mar 01 00:00:00 EST 2020
Long Term Pharmacological Perturbation of Autophagy in Mice: Are HCQ Injections a Relevant Choice?
Biomedicines
Masson JD,Blanchet B,Periou B,Authier FJ,Mograbi B,Gherardi RK,Crépeaux G
PA1-46286 was used in Western Blotting to develop a murine model of long-term systemic autophagy dysfunction, by the way of repeated injections of hydroxychloroquine (HCQ) in both juvenile and adult animals, while ensuring a limited impact on development, behaviour and motricity.
Sun Mar 01 00:00:00 EST 2020
STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts.
Scientific reports
Kinzler MN,Zielke S,Kardo S,Meyer N,Kögel D,van Wijk SJL,Fulda S
Published figure using LC3B polyclonal antibody (Product # PA1-46286) in Western Blot
Mon Jan 20 00:00:00 EST 2020
STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts.
Scientific reports
Kinzler MN,Zielke S,Kardo S,Meyer N,Kögel D,van Wijk SJL,Fulda S
Published figure using LC3B polyclonal antibody (Product # PA1-46286) in Western Blot
Mon Jan 20 00:00:00 EST 2020
Lidocaine induces protective autophagy in rat C6 glioma cell line.
International journal of oncology
Izdebska M,Hałas-Wiśniewska M,Zielińska W,Klimaszewska-Wiśniewska A,Grzanka D,Gagat M
PA1-46286 was used in Immunocytochemistry-immunoflourescence to study the effects of lidocaine on the C6 rat glioma cell line.
Fri Mar 01 00:00:00 EST 2019
CXCR4 signaling at the ovine fetal-maternal interface regulates vascularization, CD34+ cell presence, and autophagy in the endometrium†.
Biology of reproduction
Runyan CL,McIntosh SZ,Maestas MM,Quinn KE,Boren BP,Ashley RL
PA1-46286 was used in Western Blotting to investigate if CXCL12-CXCR4 signaling governs the pro-angiogenic placental microenvironment by coordinating production of central angiogenic factors and receptors and regulates endometrial cell survival essential for placental function and subsequent fetal longevity.
Mon Jul 01 00:00:00 EDT 2019
Intrauterine inhibition of chemokine receptor 4 signaling modulates local and systemic inflammation in ovine pregnancy.
American journal of reproductive immunology (New York, N.Y. : 1989)
McIntosh SZ,Maxam CJ,Maestas MM,Quinn KE,Ashley RL
PA1-46286 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot to show that intrauterine CXCL12-CXCR4 signaling governs endometrial and systemic inflammation; disruption of this axis may have detrimental impacts on offspring and maternal health.
Fri Nov 01 00:00:00 EDT 2019
Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells.
Cell death & disease
Zielke S,Meyer N,Mari M,Abou-El-Ardat K,Reggiori F,van Wijk SJL,Kögel D,Fulda S
Published figure using LC3B polyclonal antibody (Product # PA1-46286) in Immunocytochemistry
Mon Sep 24 00:00:00 EDT 2018
Autophagy in zebrafish.
Methods (San Diego, Calif.)
Varga M,Fodor E,Vellai T
PA1-46286 was used in western blot to characterize autophagy in zebrafish
Sun Mar 01 00:00:00 EST 2015
HSPB8 and the Cochaperone BAG3 Are Highly Expressed During the Synthetic Phase of Rat Myometrium Programming During Pregnancy.
Biology of reproduction
Marsh NM,Wareham A,White BG,Miskiewicz EI,Landry J,MacPhee DJ
PA1-46286 was used in western blot to study the expression of HSPB8 and BAG3 in non-pregnant and pregnant rat myometrium
Fri May 01 00:00:00 EDT 2015
