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Product Details
MA5-23916
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
472413
Immunogen
CHO-derived recombinant human LDL R Ala22-Arg788
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2609816
Product Specific Information
In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse (rm) LDL R, recombinant human LRP-5, or rmLRP-6 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LDL receptor; ldl-r; Low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
Gene Aliases: FH; FHC; LDLCQ2; LDLR
UniProt ID: (Human) P01130
Entrez Gene ID: (Human) 3949
virus receptor activity
glycoprotein binding
protease binding
receptor activity
low-density lipoprotein receptor activity
calcium ion binding
protein binding
low-density lipoprotein particle binding
very-low-density lipoprotein particle receptor activity
clathrin heavy chain binding
identical protein binding
apolipoprotein
lipid metabolic process
endocytosis
receptor-mediated endocytosis
cholesterol metabolic process
positive regulation of triglyceride biosynthetic process
regulation of phosphatidylcholine catabolic process
phospholipid transport
intestinal cholesterol absorption
cholesterol transport
low-density lipoprotein particle clearance
lipoprotein catabolic process
cholesterol homeostasis
viral entry into host cell
cholesterol import
regulation of cholesterol homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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