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Product Details
PA5-67341
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human LETMD1. Recombinant protein control fragment (Product #RP-107990).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2663698
Product Specific Information
Immunogen sequence: FPRQLLIRHFW TPKQQTDFLD IYHAFRKQSH PEIISYLEKV IPLISDAGLR WRLTDLCTKI QRG
Highest antigen sequence identity to the following orthologs - mouse 59%, rat 66%.
Target Information
HCCR-1 (human cervical cancer oncogene 1), also known as HCCR-2 or LETMD1, is a 360 amino acid single-pass membrane protein that is expressed in the kidney, liver, skeletal muscle, heart and brain. It is suggested that HCCR-1 may be involved in tumorigenesis and may function as a negative regulator of the p53 tumor suppressor. Overexpression of HCCR-1 may cause mitochondrial dysfunction that can lead to UVC or staurosporine-induced apoptosis resistance and progression of tumor formation. HCCR-1 is considered a candidate biomarker for breast cancer. Various human tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon, and uterine cervix have high HCCR-1. Six isoforms exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cervical cancer 1 proto-oncogene protein p40; Cervical cancer proto-oncogene 2 protein; HCCR-1; HCRR-2; LETM1 domain-containing protein 1; regulator of TP53
Gene Aliases: 1110019O13Rik; HCCR-1; HCCR-2; HCCR1; HCRR-2; LETMD1
UniProt ID: (Human) Q6P1Q0
Entrez Gene ID: (Human) 25875
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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