Proteintech

LIFR Polyclonal Antibody

LIFR Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

LIFR Antibody (22779-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed HeLa cells using 22779-1-AP (LIFR antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

LIFR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

LIFR Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

22779-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 3 publications 3 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LIFR Fusion Protein Ag18742 (906-1097 aa encoded by BC153096)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NNVEVLETR SAFPKIEDTE IISPVAERPE DRSDAEPENH VVVSYCPPII EEEIPNPAAD EAGGTAQVIY IDVQSMYQPQ AKPEEEQEND PVGGAGYKPQ MHLPINSTVE DIAAEEDLDK TAGYRPQANV NTWNLVSPDS PRSIDSNSEI VSFGSPCSIN SRQFLIPPKD EDSPKSNGGG WSFTNFFQNK PND (906-1097 aa encoded by B C153096)

Target Information

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling.

Journal of translational medicine

Feng Y,Yuan Y,Xia H,Wang Z,Che Y,Hu Z,Deng J,Li F,Wu Q,Bian Z,Zhou H,Shen D,Tang Q

Sat Apr 29 00:00:00 EDT 2023

OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling.

Journal of translational medicine

Feng Y,Yuan Y,Xia H,Wang Z,Che Y,Hu Z,Deng J,Li F,Wu Q,Bian Z,Zhou H,Shen D,Tang Q

Sat Apr 29 00:00:00 EDT 2023

Pan-cancer analysis identifies LIFR as a prognostic and immunological biomarker for uterine corpus endometrial carcinoma.

Frontiers in oncology

Zhang F,Wang Y,Li H,Li L,Yang X,You X,Tang L

Sat Mar 18 00:00:00 EDT 2023

LIFR recruits HGF-producing neutrophils to promote liver injury repair and regeneration.

bioRxiv : the preprint server for biology

Deng Y,Zhao Z,Sheldon M,Zhao Y,Teng H,Martinez C,Zhang J,Lin C,Sun Y,Yao F,Zhu H,Ma L

Tue Mar 21 00:00:00 EDT 2023

LIFR recruits HGF-producing neutrophils to promote liver injury repair and regeneration.

bioRxiv : the preprint server for biology

Deng Y,Zhao Z,Sheldon M,Zhao Y,Teng H,Martinez C,Zhang J,Lin C,Sun Y,Yao F,Zhu H,Ma L

Tue Mar 21 00:00:00 EDT 2023

LIFR recruits HGF-producing neutrophils to promote liver injury repair and regeneration.

bioRxiv : the preprint server for biology

Deng Y,Zhao Z,Sheldon M,Zhao Y,Teng H,Martinez C,Zhang J,Lin C,Sun Y,Yao F,Zhu H,Ma L

Tue Mar 21 00:00:00 EDT 2023

Exosomes from human umbilical cord mesenchymal stem cells protect aortas in Db/db mice characterized by combination of metabolomics and proteomics.

Archives of biochemistry and biophysics

Ling MY,Yang XC,Yu N,Song YP,Zheng YJ,Tang CM,Ding WJ,Sun Y,Yan R,Wang SP,Li XH,Gao HQ,Zhang Z,Xing YQ

Wed Nov 30 00:00:00 EST 2022

MgFe-LDH Nanoparticles: A Promising Leukemia Inhibitory Factor Replacement for Self-Renewal and Pluripotency Maintenance in Cultured Mouse Embryonic Stem Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

He X,Zhu Y,Yang L,Wang Z,Wang Z,Feng J,Wen X,Cheng L,Zhu R

Sat May 01 00:00:00 EDT 2021

A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis.

Nature communications

Yao F,Deng Y,Zhao Y,Mei Y,Zhang Y,Liu X,Martinez C,Su X,Rosato RR,Teng H,Hang Q,Yap S,Chen D,Wang Y,Chen MM,Zhang M,Liang H,Xie D,Chen X,Zhu H,Chang JC,You MJ,Sun Y,Gan B,Ma L

Fri Dec 17 00:00:00 EST 2021

Exercise plasma boosts memory and dampens brain inflammation via clusterin.

Nature

De Miguel Z,Khoury N,Betley MJ,Lehallier B,Willoughby D,Olsson N,Yang AC,Hahn O,Lu N,Vest RT,Bonanno LN,Yerra L,Zhang L,Saw NL,Fairchild JK,Lee D,Zhang H,McAlpine PL,Contrepois K,Shamloo M,Elias JE,Rando TA,Wyss-Coray T

Wed Dec 01 00:00:00 EST 2021

Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.

Clinical and translational medicine

Liu AD,Zhou J,Bi XY,Hou GQ,Li SS,Chen Q,Xu H,Cao X

Mon Mar 01 00:00:00 EST 2021

Detachment of cell sheets from clinically ubiquitous cell culture vessels by ultrasonic vibration.

Scientific reports

Imashiro C,Hirano M,Morikura T,Fukuma Y,Ohnuma K,Kurashina Y,Miyata S,Takemura K

Thu Jun 11 00:00:00 EDT 2020

Construction and Comprehensive Analysis of a ceRNA Network to Reveal Potential Novel Biomarkers for Triple-Negative Breast Cancer.

Cancer management and research

Ma L,Song G,Li M,Hao X,Huang Y,Lan J,Yang S,Zhang Z,Zhang G,Mu J

Sat Apr 16 00:00:00 EDT 2022

Enzyme-free release of adhered cells from standard culture dishes using intermittent ultrasonic traveling waves.

Communications biology

Kurashina Y,Imashiro C,Hirano M,Kuribara T,Totani K,Ohnuma K,Friend J,Takemura K

Mon Apr 27 00:00:00 EDT 2020

Cell Patterning Method on a Clinically Ubiquitous Culture Dish Using Acoustic Pressure Generated From Resonance Vibration of a Disk-Shaped Ultrasonic Transducer.

IEEE transactions on bio-medical engineering

Imashiro C,Kurashina Y,Kuribara T,Hirano M,Totani K,Takemura K

Tue Jan 01 00:00:00 EST 2019

Formation of Large Scaffold-Free 3-D Aggregates in a Cell Culture Dish by Ultrasound Standing Wave Trapping.

Ultrasound in medicine & biology

Nakao M,Imashiro C,Kuribara T,Kurashina Y,Totani K,Takemura K

Wed May 01 00:00:00 EDT 2019

miR-589 promotes gastric cancer aggressiveness by a LIFR-PI3K/AKT-c-Jun regulatory feedback loop.

Journal of experimental & clinical cancer research : CR

Zhang F,Li K,Pan M,Li W,Wu J,Li M,Zhao L,Wang H

Mon Jul 16 00:00:00 EDT 2018

miR-589 promotes gastric cancer aggressiveness by a LIFR-PI3K/AKT-c-Jun regulatory feedback loop.

Journal of experimental & clinical cancer research : CR

Zhang F,Li K,Pan M,Li W,Wu J,Li M,Zhao L,Wang H

Mon Jul 16 00:00:00 EDT 2018

Enzyme-free cell detachment mediated by resonance vibration with temperature modulation.

Biotechnology and bioengineering

Kurashina Y,Hirano M,Imashiro C,Totani K,Komotori J,Takemura K

Sun Oct 01 00:00:00 EDT 2017

Enzyme-free cell detachment mediated by resonance vibration with temperature modulation.

Biotechnology and bioengineering

Kurashina Y,Hirano M,Imashiro C,Totani K,Komotori J,Takemura K

Sun Oct 01 00:00:00 EDT 2017

Mutations in the leukemia inhibitory factor receptor (LIFR) gene and Lifr deficiency cause urinary tract malformations.

Human molecular genetics

Kosfeld A,Brand F,Weiss AC,Kreuzer M,Goerk M,Martens H,Schubert S,Schäfer AK,Riehmer V,Hennies I,Bräsen JH,Pape L,Amann K,Krogvold L,Bjerre A,Daniel C,Kispert A,Haffner D,Weber RG

Mon May 01 00:00:00 EDT 2017

Mutations in the leukemia inhibitory factor receptor (LIFR) gene and Lifr deficiency cause urinary tract malformations.

Human molecular genetics

Kosfeld A,Brand F,Weiss AC,Kreuzer M,Goerk M,Martens H,Schubert S,Schäfer AK,Riehmer V,Hennies I,Bräsen JH,Pape L,Amann K,Krogvold L,Bjerre A,Daniel C,Kispert A,Haffner D,Weber RG

Mon May 01 00:00:00 EDT 2017

Mutations in the leukemia inhibitory factor receptor (LIFR) gene and Lifr deficiency cause urinary tract malformations.

Human molecular genetics

Kosfeld A,Brand F,Weiss AC,Kreuzer M,Goerk M,Martens H,Schubert S,Schäfer AK,Riehmer V,Hennies I,Bräsen JH,Pape L,Amann K,Krogvold L,Bjerre A,Daniel C,Kispert A,Haffner D,Weber RG

Mon May 01 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: CD118; CD118 antigen; D-factor/LIF receptor; FLJ98106; FLJ99923; Leukemia inhibitory factor receptor; leukemia inhibitory factor receptor alpha chain; LIF R beta; LIF receptor; LIF-R; soluble differentiation-stimulating factor receptor

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Gene Aliases: A230075M04Rik; AW061234; CD118; LIF; LIF-R; LIFR; SJS2; STWS; SWS

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UniProt ID: (Human) P42702, (Mouse) P42703

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Entrez Gene ID: (Human) 3977, (Mouse) 16880

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Function(s)

ciliary neurotrophic factor receptor activity leukemia inhibitory factor receptor activity oncostatin-M receptor activity ciliary neurotrophic factor receptor binding protein binding growth factor binding cytokine binding protein heterodimerization activity cytokine receptor activity transmembrane signal receptor

Process(es)

cell surface receptor signaling pathway positive regulation of cell proliferation negative regulation of muscle cell apoptotic process response to organic cyclic compound cytokine-mediated signaling pathway organ regeneration response to cytokine oncostatin-M-mediated signaling pathway neuron projection morphogenesis leukemia inhibitory factor signaling pathway ciliary neurotrophic factor-mediated signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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LIFR Polyclonal Antibody

LIFR Antibody (22779-1-AP) in ICC/IF

Product Details

22779-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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