Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 1
Positive Samples: Raji, LO2, A-549, 293T, THP-1; Cellular Location: Cell membrane, Cytoplasm, Single-pass type II membrane protein
Immunogen sequence: LQLHWRLGEM VTRLPDGPAG SWEQLIQERR SHEVNPAAHL TGANSSLTGS GGPLLWETQL GLAFLRGLSY HDGALVVTKA GYYYIYSKVQ LGGVGCPLGL ASTITHGLYK RTPRYPEE
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD258; Herpes virus entry mediator ligand; herpesvirus entry mediator ligand; HVEM-L; sCD258; sLIGHT; soluble CD258; soluble LIGHT; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand 1D; Tumor necrosis factor ligand superfamily member 14
Gene Aliases: CD258; HVEM-L; HVEML; LIGHT; LTg; Ly113; TNFSF14; UNQ391/PRO726
UniProt ID: (Human) O43557, (Mouse) Q9QYH9
Entrez Gene ID: (Human) 8740, (Rat) 301133, (Mouse) 50930
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