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LILRA3 Antibody (PA5-47349) in Flow
Flow cytometry of LILRA3 in Human peripheral blood monoctyes were stained with Mouse Anti-Human CD14 APC‚conjugated Monoclonal Antibody. Samples were incubated in either (A) LILRA3 polyclonal antibody (Product # PA5-47349) or (B) Normal Goat IgG Control followed by Phycoerythrin-conjugated Anti-Goat IgG Secondary Antibody. To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer and permeabilized with Flow Cytometry Permeabilization/Wash Buffer.
Product Details
PA5-47349
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human LILRA3/CD85e Arg18-Glu439
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2606668
Product Specific Information
In direct ELISAs, approximately 30% cross-reactivity with recombinant human (rh) ILT2, rhILT4, ILT5 is observed, and less than 5% cross-reactivity with rhLIR5 and rhLIR7 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades (see LILRA1, MIM 604810). One member of subfamily A (LILRA3) lacks a transmembrane region and is presumed to be a soluble receptor (Borges et al., 1997 [PubMed 9548455]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD85 antigen-like family member E; CD85e; ILT-6; Immunoglobulin-like transcript 6; leucocyte Ig-like receptor A3; Leukocyte immunoglobulin-like receptor 4; leukocyte immunoglobulin-like receptor A3; Leukocyte immunoglobulin-like receptor subfamily A member 3; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3; LIR-4; Monocyte inhibitory receptor HM43/HM31
Gene Aliases: CD85E; HM31; HM43; ILT-6; ILT6; LILRA3; LIR-4; LIR4
UniProt ID: (Human) Q8N6C8
Entrez Gene ID: (Human) 11026
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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