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Product Details
26455-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LILRB1 Fusion Protein Ag24795
Conjugate
Form
Liquid
Concentration
333 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD85 antigen-like family member J; CD85j; Ig-like transcript 2; ILT-2; Immunoglobulin-like transcript 2; leucocyte Ig-like receptor B1; Leukocyte immunoglobulin-like receptor subfamily B member 1; leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; LIR-1; MIR-7; Monocyte/macrophage immunoglobulin-like receptor 7; myeloid inhibitory receptor 7
Gene Aliases: CD85J; ILT-2; ILT2; LILRB1; LIR-1; LIR1; MIR-7; MIR7; PIR-B; PIRB
UniProt ID: (Human) Q8NHL6
Entrez Gene ID: (Human) 10859
negative regulation of T cell mediated cytotoxicity
positive regulation of defense response to virus by host
adaptive immune response
T cell proliferation involved in immune response
negative regulation of cytokine secretion involved in immune response
immune response-inhibiting cell surface receptor signaling pathway
Fc receptor mediated inhibitory signaling pathway
signal transduction
response to virus
positive regulation of gene expression
negative regulation of serotonin secretion
receptor internalization
interferon-gamma production
negative regulation of interferon-gamma production
negative regulation of mononuclear cell proliferation
negative regulation of interferon-beta secretion
negative regulation of T cell proliferation
negative regulation of tumor necrosis factor biosynthetic process
positive regulation of apoptotic process
negative regulation of interferon-gamma biosynthetic process
negative regulation of cell cycle
negative regulation of endocytosis
positive regulation of cytolysis
positive regulation of transcription from RNA polymerase II promoter
negative regulation of natural killer cell mediated cytotoxicity
negative regulation of alpha-beta T cell activation
regulation of immune response
defense response to virus
negative regulation of calcium ion transport
cellular response to lipopolysaccharide
interferon-gamma secretion
dendritic cell differentiation
negative regulation of dendritic cell apoptotic process
negative regulation of interleukin-10 secretion
negative regulation of interleukin-12 secretion
negative regulation of CD8-positive, alpha-beta T cell activation
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
positive regulation of gamma-delta T cell activation involved in immune response
negative regulation of dendritic cell differentiation
negative regulation of transforming growth factor-beta secretion
negative regulation of osteoclast development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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