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Product Details
PA5-50440
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein corresponding to a region derived from internal residues of human LIM and senescent cell antigen-like domains 1
Conjugate
Form
Liquid
Concentration
1.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2635893
Product Specific Information
The antibody detects endogenous levels of total LIMS1 protein.
Target Information
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LIM and senescent cell antigen-like domains 1; LIM and senescent cell antigen-like-containing domain protein 1; LIM-type zinc finger domains 1; Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48; senescent cell antigen
Gene Aliases: 2310016J22Rik; 4921524A02Rik; AI507642; AU021743; AW551584; C430041B13Rik; LIMS1; Lims1l; PINCH; PINCH-1; PINCH1
UniProt ID: (Human) P48059, (Mouse) Q99JW4
Entrez Gene ID: (Human) 3987, (Mouse) 110829
epithelial to mesenchymal transition
cell aging
positive regulation of gene expression
positive regulation of cell-substrate adhesion
cell junction assembly
positive regulation of GTPase activity
establishment of protein localization
negative regulation of transcription, DNA-templated
regulation of epithelial cell proliferation
positive regulation of focal adhesion assembly
cellular response to transforming growth factor beta stimulus
positive regulation of substrate adhesion-dependent cell spreading
cell-matrix adhesion
establishment or maintenance of cell polarity
single organismal cell-cell adhesion
chordate embryonic development
negative regulation of apoptotic process
cell-cell junction organization
negative regulation of epithelial cell proliferation
protein heterooligomerization
negative regulation of neural precursor cell proliferation
negative regulation of hepatocyte proliferation
positive regulation of integrin-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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