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The antibody detects endogenous levels of total LLGL2 protein.
LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HGL; human giant larvae homolog; lethal giant larvae homolog 2; lethal giant larvae homolog 2, scribble cell polarity complex component; Lethal(2) giant larvae protein homolog 2; LLGL scribble cell polarity complex component 2
Gene Aliases: HGL; Hugl-2; LGL2; LLGL2
UniProt ID: (Human) Q6P1M3
Entrez Gene ID: (Human) 3993
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